research overview
- Professor Watkins’ research focuses on glial dysregulation of pain and opioid actions.
- Contact Info
Watkins, Linda R
Positions
- Distinguished Professor, Psychology and Neuroscience
Research Areas
Research
keywords
- glial dysregulation of pain and opioid actions
Publications
selected publications
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book
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chapter
- Drug Addiction. 299-318. 2014
- The future: new concepts and potential therapies. 341-356. 2013
- An awake behaving rat model for the study of dural inflammation-induced facial allodyna: a rat model relevant to migraine 2012
- Unilateral T13 and L1 Avulsion: methods for a novel model of central neuropathic pain 2012
- The role of the immune system in chronic pain comorbidities 2012
- The role of the medial prefrontal cortex in mediating resistance and vulnerability to the impact of adverse events 2009
- Glially driven enhancement of pain and its control by anti-inflammatory cytokines 2007
- Proinflammatory cytokines modulate neuropathic pain, opioid analgesia, and opioid tolerance 2007
- Neuroimmune Interactions and Pain: The Role of Immune and Glial Cells. 393-414. 2007
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Contribution of glia to pain processing in health and disease.
Handbook of Clinical Neurology.
309-323.
2006
- Glia and pain: Past, present and future 2005
- Multiple routes of action of interleukin-1 on the nervous system 2001
- Illness-induced hyperalgesia: mediators, mechanisms and implications 1999
- Neural, endocrine, and immune mechanisms of stress-induced immunomodulation 1998
- Stress and cytokine-brain interactions 1998
- Algesiometry in laboratory animals and man: current concepts and future directions 1989
- Interaction of cholecystokinin and opioids in pain modulation 1987
- BEHAVIORAL AND ELECTROPHYSIOLOGICAL INVESTIGATIONS OF OPIATE CHOLECYSTOKININ INTERACTIONS. Advances in pain research and therapy. 541-553. 1985
- Localization of the CNS sites mediating epileptiform activity elicited by morphine and endogenous opioids 1984
- MULTIPLE ENDOGENOUS OPIATE AND NONOPIATE ANALGESIA SYSTEMS. Advances in pain research and therapy. 253-276. 1984
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ORGANIZATION OF ENDOGENOUS OPIATE AND NON-OPIATE PAIN CONTROL-SYSTEMS.
Science.
1185-1192.
1982
- The role of endorphins in endogenous pain control systems 1981
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conference proceeding
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Glucocorticoids mediate stress-induced upregulation of the alarmin HMGB1 and downregulation of the inhibitory receptor CD200R1 in hippocampus and amygdala: A mechanism of neuroinflammatory priming.
Brain, Behavior, and Immunity.
E2-E3.
2019
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Mycobacterium vaccae immunization protects aged rats from surgery-elicited neuroinflammation and cognitive dysfunction.
Brain, Behavior, and Immunity.
E36-E36.
2019
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Spinal cord injury perturbs circadian rhythms.
Brain, Behavior, and Immunity.
E39-E39.
2019
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The TLR2/4 antagonist (+)-naltrexone blocks contextual long-term memory deficits in experimental autoimmune encephalitis and associated neuroinflammation in hippocampus.
Brain, Behavior, and Immunity.
E34-E35.
2019
- Immunization with Mycobacterium vaccae induces an anti-inflammatory milieu in the CNS: attenuation of stress-induced microglial priming, alarmins and anxiety-like behavior 2018
- Improved Quality of Life in Dogs with OA After Intra-Articular XT-150 hIL-10v Plasmid DNA. Molecular Therapy. 195-195. 2017
- XT-101 PLGA/Human IL-10v Plasmid Promotes Improved Quality of Life in Companion Dogs with Osteoarthritis. Molecular Therapy. 144-144. 2017
- . Previous Inescapable Stress Interferes with the Immunizing, but not the Acute, Effect of Later Escapable Stressors. Society for Neuroscience 2017
- A neuroimmune basis for chronic pain in a rat model of Gulf War Illness 2017
- Diurnal variation of the effect of an acute stressor on an anxiety-like behavior 2017
- Evaluating Stressor Controllability Effects in Female Rats 2017
- Exposure to an acute stressor disinhibits microglia via down-regulation of CD200R: a mechanism of neuroinflammatory and microglial priming. 2017
- Investigating the fear-reducing effects of controllable stress with a robust activity marking system. 2017
- S.J. High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory. 2017
- Immune and glial involvement in physiological and pathological exaggerated pain states. 369-385. 2002
- The neurobiology of stressor controllability. 41-56. 1998
- Vagal afferent nerve mediates immune signals to the brain. Taniguchi Symposia on Brain Sciences. 143-151. 1998
- Neural, endocrine, and immune mechanisms of stress-induced immunomodulation. 175-185. 1996
- Stress and cytokine-brain interactions. 187-194. 1996
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Glucocorticoids mediate stress-induced upregulation of the alarmin HMGB1 and downregulation of the inhibitory receptor CD200R1 in hippocampus and amygdala: A mechanism of neuroinflammatory priming.
Brain, Behavior, and Immunity.
E2-E3.
2019
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journal article
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An initial investigation of transcutaneous delivery of plasmid DNA encoding interleukin-10 for the treatment of psoriatic skin conditions..
Brain, Behavior, and Immunity.
903-913.
2024
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Microglia in neuroimmunopharmacology and drug addiction.
Molecular Psychiatry.
2024
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Interleukin-1beta and inflammasome expression in spinal cord following chronic constriction injury in male and female rats.
Brain, Behavior, and Immunity.
157-168.
2024
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Voluntary wheel running prevents formation of membrane attack complexes and myelin degradation after peripheral nerve injury.
Brain, Behavior, and Immunity.
419-431.
2024
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Combining RNAscope and immunohistochemistry to visualize inflammatory gene products in neurons and microglia.
Frontiers in Molecular Neuroscience.
2023
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Intrathecal non-viral interleukin-10 gene therapy ameliorates neuropathic pain as measured by both classical static allodynia and a novel supra-spinally mediated pain assay, the Two-Arm Rodent Somatosensory (TARS) task.
Brain, Behavior, and Immunity.
177-185.
2023
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Toll-like receptor 4 antagonists reduce cocaine-primed reinstatement of drug seeking.
Psychopharmacology.
1587-1600.
2023
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Mechanisms of microglia-mediated synapse turnover and synaptogenesis.
Progress in Neurobiology.
2022
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Involvement of TLR2-TLR4, NLRP3, and IL-17 in pain induced by a novel Sprague-Dawley rat model of experimental autoimmune encephalomyelitis.
Frontiers in Pain Research.
2022
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T cell transgressions: tales of T cell form and function in diversedisease states.
International Reviews of Immunology.
475-516.
2022
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Suppression of active phase voluntary wheel running in male rats by unilateral chronic constriction injury: Enduring therapeutic effects of a brief treatment of morphine combined with TLR4 or P2X7 antagonists.
Journal of Neuroscience Research.
265-277.
2022
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Aging and miR-155 in mice influence survival and neuropathic pain after spinal cord injury.
Brain, Behavior, and Immunity.
365-370.
2021
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Nicotine and its metabolite cotinine target MD2 and inhibit TLR4 signaling.
The Innovation.
2021
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Toll -like receptor 2 and 4 antagonism for the treatment of experimental autoimmune encephalomyelitis (EAE)-related pain.
Brain, Behavior, and Immunity.
80-95.
2021
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Postoperative cognitive dysfunction is made persistent with morphine treatment in aged rats.
Neurobiology of Aging.
214-224.
2021
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Autoimmune regulation of chronic pain.
PAIN Reports.
2021
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Experimental autoimmune encephalopathy (EAE)-induced hippocampal neuroinflammation and memory deficits are prevented with the non-opioid TLR2/TLR4 antagonist (+)-naltrexone.
Behavioural Brain Research.
2021
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Acute stress induces the rapid and transient induction of caspase-1, gasdermin D and release of constitutive IL-1 beta protein in dorsal hippocampus.
Brain, Behavior, and Immunity.
70-80.
2020
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Targeted interleukin-10 plasmid DNA therapy in the treatment of osteoarthritis: Toxicology and pain efficacy assessments.
Brain, Behavior, and Immunity.
155-166.
2020
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Acute stress induces chronic neuroinflammatory, microglial and behavioral priming: A role for potentiated NLRP3 inflammasome activation.
Brain, Behavior, and Immunity.
32-42.
2020
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Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents.
Pain.
2107-2118.
2020
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The behavioral and neurochemical effects of an inescapable stressor are time of day dependent.
Stress: the International Journal on the Biology of Stress.
405-416.
2020
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TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes.
Neurobiology of Disease.
2019
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Lovastatin inhibits Toll-like receptor 4 signaling in microglia by targeting its co-receptor myeloid differentiation protein 2 and attenuates neuropathic pain.
Brain, Behavior, and Immunity.
432-444.
2019
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Oxycodone, fentanyl, and morphine amplify established neuropathic pain in male rats.
Pain.
2634-2640.
2019
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Microglia: Neuroimmune-sensors of stress.
Seminars in Cell and Developmental Biology.
176-185.
2019
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Glucocorticoids mediate stress induction of the alarmin HMGB1 and reduction of the microglia checkpoint receptor CD200R1 in limbic brain structures.
Brain, Behavior, and Immunity.
678-687.
2019
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Methamphetamine Activates Toll-Like Receptor 4 to Induce Central Immune Signaling within the Ventral Tegmental Area and Contributes to Extracellular Dopamine Increase in the Nucleus Accumbens Shell.
ACS Chemical Neuroscience.
3622-3634.
2019
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Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling.
The FASEB Journal.
9577-9587.
2019
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Spinal Cord Injury in Rats Dysregulates Diurnal Rhythms of Fecal Output and Liver Metabolic Indicators.
Journal of Neurotrauma.
1923-1934.
2019
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A single peri-sciatic nerve administration of the adenosine 2A receptor agonist ATL313 produces long-lasting anti-allodynia and anti-inflammatory effects in male rats.
Brain, Behavior, and Immunity.
116-125.
2019
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Circadian misalignment has differential effects on affective behavior following exposure to controllable or uncontrollable stress.
Behavioural Brain Research.
440-445.
2019
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Could Probiotics Be Used to Mitigate Neuroinflammation?.
ACS Chemical Neuroscience.
13-15.
2019
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Repeated Morphine Prolongs Postoperative Pain in Male Rats.
Anesthesia and Analgesia.
161-167.
2019
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Mycobacterium vaccae immunization protects aged rats from surgery-elicited neuroinflammation and cognitive dysfunction.
Neurobiology of Aging.
105-114.
2018
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Spinal Cord Injury in Rats Disrupts the Circadian System.
eNeuro.
2018
-
Immunization with Mycobacterium vaccae induces an anti-inflammatory milieu in the CNS: Attenuation of stress-induced microglial priming, alarmins and anxiety-like behavior.
Brain, Behavior, and Immunity.
352-363.
2018
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MicroRNA-124 and microRNA-146a both attenuate persistent neuropathic pain induced by morphine in male rats.
Brain Research.
9-11.
2018
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Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats.
Brain, Behavior, and Immunity.
45-50.
2018
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A novel platform for in vivo detection of cytokine release within discrete brain regions.
Brain, Behavior, and Immunity.
18-22.
2018
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DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats.
Experimental Neurology.
125-131.
2018
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DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats..
Experimental Neurology.
125-131.
2018
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MicroRNAs: Roles in Regulating Neuroinflammation.
The Neuroscientist: reviews at the interface of basic and clinical neurosciences.
221-245.
2018
-
Neuroinflammatory priming to stress is differentially regulated in male and female rats.
Brain, Behavior, and Immunity.
257-267.
2018
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Behavioural and neural sequelae of stressor exposure are not modulated by controllability in females.
European Journal of Neuroscience.
959-967.
2018
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Dissecting the Innate Immune Recognition of Opioid Inactive Isomer (+)-Naltrexone Derived Toll-like Receptor 4 (TLR4) Antagonists.
Journal of Chemical Information and Modeling.
816-825.
2018
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Toll-like receptors and their role in persistent pain.
Pharmacology and Therapeutics.
145-158.
2018
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Post-stroke Intranasal (+)-Naloxone Delivery Reduces Microglial Activation and Improves Behavioral Recovery from Ischemic Injury.
eNeuro.
2018
-
Stress disinhibits microglia via down-regulation of CD200R: A mechanism of neuroinflammatory priming.
Brain, Behavior, and Immunity.
62-73.
2018
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Sustained reversal of central neuropathic pain induced by a single intrathecal injection of adenosine A2A receptor agonists.
Brain, Behavior, and Immunity.
470-479.
2018
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Inhibition of a Descending Prefrontal Circuit Prevents Ketamine-Induced Stress Resilience in Females.
eNeuro.
2018
-
Innate immune signaling in the ventral tegmental area contributes to drug-primed reinstatement of cocaine seeking.
Brain, Behavior, and Immunity.
130-138.
2018
-
High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory.
Neurobiology of Aging.
88-101.
2017
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Opioid Self-Administration is Attenuated by Early-Life Experience and Gene Therapy for Anti-Inflammatory IL-10 in the Nucleus Accumbens of Male Rats.
Neuropsychopharmacology.
2128-2140.
2017
-
Exploring acute-to-chronic neuropathic pain in rats after contusion spinal cord injury.
Experimental Neurology.
46-54.
2017
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Constriction of the buccal branch of the facial nerve produces unilateral craniofacial allodynia.
Brain, Behavior, and Immunity.
59-64.
2017
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Supradural inflammatory soup in awake and freely moving rats induces facial allodynia that is blocked by putative immune modulators.
Brain Research.
87-94.
2017
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Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy.
Brain, Behavior, and Immunity.
49-54.
2017
- Mycobacterium vaccae induces an anti-inflammatory milieu in the CNS: effects on stress-induced neuroinflammation. Biological Psychiatry. 2017
- Spinal cord injury in rats disrupts bowel function 2017
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Nitroxidative Signaling Mechanisms in Pathological Pain.
Trends in Neurosciences.
862-879.
2016
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Stable, long-term, spatial memory in young and aged rats achieved with a one day Morris water maze training protocol.
Learning and Memory.
699-702.
2016
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Diminished circadian rhythms in hippocampal microglia may contribute to age-related neuroinflammatory sensitization.
Neurobiology of Aging.
102-112.
2016
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Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury.
Brain, Behavior, and Immunity.
348-356.
2016
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HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia.
Cell Reports.
1128-1140.
2016
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Stress-induced neuroinflammatory priming: A liability factor in the etiology of psychiatric disorders.
Neurobiology of Stress.
62-70.
2016
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Glial contributions to visceral pain: implications for disease etiology and the female predominance of persistent pain.
Translational Psychiatry.
2016
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Activation of a Habenulo-Raphe Circuit Is Critical for the Behavioral and Neurochemical Consequences of Uncontrollable Stress in the Male Rat.
eNeuro.
2016
-
Prior voluntary wheel running attenuates neuropathic pain.
Pain.
2012-2023.
2016
-
The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming.
The Journal of Neuroscience.
7946-7956.
2016
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Glucocorticoids Mediate Short-Term High-Fat Diet Induction of Neuroinflammatory Priming, the NLRP3 Inflammasome, and the Danger Signal HMGB1.
eNeuro.
2016
-
The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: A role for the NLRP3 inflammasome.
Brain, Behavior, and Immunity.
215-224.
2016
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Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation.
Proceedings of the National Academy of Sciences of USA.
E3441-E3450.
2016
-
Stress-induced neuroinflammatory priming is time of day dependent.
Psychoneuroendocrinology.
82-90.
2016
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Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as antagonists of toll-like receptor 4.
British Journal of Pharmacology.
856-869.
2016
-
Previous Ketamine Produces an Enduring Blockade of Neurochemical and Behavioral Effects of Uncontrollable Stress.
The Journal of Neuroscience.
153-161.
2016
-
The danger-associated molecular pattern HMGB1 mediates the neuroinflammatory effects of methamphetamine.
Brain, Behavior, and Immunity.
99-108.
2016
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DAT isn't all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling.
Molecular Psychiatry.
1525-1537.
2015
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NEUROINFLAMMATION IN THE NORMAL AGING HIPPOCAMPUS.
Neuroscience.
84-99.
2015
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The therapeutic potential of interleukin-10 in neuroimmune diseases.
Neuropharmacology.
55-69.
2015
-
(+)-Naltrexone is neuroprotective and promotes alternative activation in the mouse hippocampus after cardiac arrest/cardiopulmonary resuscitation.
Brain, Behavior, and Immunity.
115-122.
2015
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Stress sounds the alarmin: The role of the danger-associated molecular pattern HMGB1 in stress-induced neuroinflammatory priming.
Brain, Behavior, and Immunity.
1-7.
2015
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The permissive role of glucocorticoids in neuroinflammatory priming: mechanisms and insights.
Current Opinion in Endocrinology, Diabetes and Obesity.
300-305.
2015
-
Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists.
Journal of Medicinal Chemistry.
5038-5052.
2015
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Adenosine 2A receptor agonism: A single intrathecal administration attenuates motor paralysis in experimental autoimmune encephalopathy in rats.
Brain, Behavior, and Immunity.
50-54.
2015
-
Opioid-Induced Central Immune Signaling: Implications for Opioid Analgesia.
Headache.
475-489.
2015
-
Alcohol-induced sedation and synergistic interactions between alcohol and morphine: A key mechanistic role for Toll-like receptors and MyD88-dependent signaling.
Brain, Behavior, and Immunity.
245-252.
2015
-
Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia.
Neurobiology of Aging.
1483-1495.
2015
-
Microglia inflammatory responses are controlled by an intrinsic circadian clock.
Brain, Behavior, and Immunity.
171-179.
2015
-
Pioglitazone rapidly reduces neuropathic pain through astrocyte and nongenomic PPAR-Îł mechanisms.
Pain.
469-482.
2015
-
Select steroid hormone glucuronide metabolites can cause toll-like receptor 4 activation and enhanced pain.
Brain, Behavior, and Immunity.
128-136.
2015
-
Stress Induces the Danger-Associated Molecular Pattern HMGB-1 in the Hippocampus of Male Sprague Dawley Rats: A Priming Stimulus of Microglia and the NLRP3 Inflammasome.
The Journal of Neuroscience.
316-324.
2015
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Targeting the Toll of Drug Abuse: The Translational Potential of Toll-Like Receptor 4.
CNS and Neurological Disorders.
692-699.
2015
-
The role of hepatic and splenic macrophages in E. coli-induced memory impairments in aged rats.
Brain, Behavior, and Immunity.
60-67.
2015
-
ACTIVATION OF ADULT RAT CNS ENDOTHELIAL CELLS BY OPIOID-INDUCED TOLL-LIKE RECEPTOR 4 (TLR4) SIGNALING INDUCES PROINFLAMMATORY, BIOCHEMICAL, MORPHOLOGICAL, AND BEHAVIORAL SEQUELAE.
Neuroscience.
299-317.
2014
-
High-fat diet consumption disrupts memory and primes elevations in hippocampal IL-1β, an effect that can be prevented with dietary reversal or IL-1 receptor antagonism.
Brain, Behavior, and Immunity.
22-32.
2014
-
Glial TLR4 signaling does not contribute to opioid-induced depression of respiration.
Journal of Applied Physiology.
857-868.
2014
-
Learned stressor resistance requires extracellular signal-regulated kinase in the prefrontal cortex.
Frontiers in Behavioral Neuroscience.
2014
-
In vivo veritas: (+)-Naltrexone's actions define translational importance A letter in response to Skolnick et al. 'Translational potential of naloxone and naltrexone as TLR4 antagonists'.
Trends in Pharmacological Sciences.
432-433.
2014
-
Control over a stressor involves the posterior dorsal striatum and the act/outcome circuit.
European Journal of Neuroscience.
2352-2358.
2014
-
A concern on comparing 'apples' and 'oranges' when differences between microglia used in human and rodent studies go far, far beyond simply species: comment on Smith and Dragunow.
Trends in Neurosciences.
189-190.
2014
-
Pathological pain and the neuroimmune interface.
Nature Reviews Immunology.
217-231.
2014
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Systemic Administration of Propentofylline, Ibudilast, and (+)-Naltrexone Each Reverses Mechanical Allodynia in a Novel Rat Model of Central Neuropathic Pain.
Journal of Pain.
407-421.
2014
-
Reversal of Established Traumatic Brain Injury-Induced, Anxiety-Like Behavior in Rats after Delayed, Post-Injury Neuroimmune Suppression.
Journal of Neurotrauma.
487-497.
2014
-
Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus.
Psychoneuroendocrinology.
191-200.
2014
-
Suppression of Voluntary Wheel Running in Rats Is Dependent on the Site of Inflammation: Evidence for Voluntary Running as a Measure of Hind Paw-Evoked Pain.
Journal of Pain.
121-128.
2014
-
Discovery of a Novel Site of Opioid Action at the Innate Immune Pattern-Recognition Receptor TLR4 and its Role in Addiction.
International Review of Neurobiology.
129-163.
2014
-
Why is neuroimmunopharmacology crucial for the future of addiction research?.
Neuropharmacology.
218-227.
2014
-
Intrathecal injection of adenosine 2A receptor agonists reversed neuropathic allodynia through protein kinase (PK)A/PKC signaling.
Brain, Behavior, and Immunity.
112-122.
2013
-
Stress-induced glucocorticoids as a neuroendocrine alarm signal of danger.
Brain, Behavior, and Immunity.
1-6.
2013
-
Blocking toll-like receptor 2 and 4 signaling during a stressor prevents stress-induced priming of neuroinflammatory responses to a subsequent immune challenge.
Brain, Behavior, and Immunity.
112-121.
2013
-
Anxiogenic effects of brief swim stress are sensitive to stress history.
Progress in Neuro-Psychopharmacology and Biological Psychiatry.
17-22.
2013
-
Rifampin inhibits Toll-like receptor 4 signaling by targeting myeloid differentiation protein 2 and attenuates neuropathic pain.
The FASEB Journal.
2713-2722.
2013
-
A minocycline derivative reduces nerve injury-induced allodynia, LPS-induced prostaglandin E2 microglial production and signaling via toll-like receptors 2 and 4.
Neuroscience Letters.
157-162.
2013
-
Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain.
Brain, Behavior, and Immunity.
24-32.
2013
-
Effect of Chronic. Delivery of the Toll-like Receptor 4 Antagonist (+)-Naltrexone on Incubation of Heroin Craving.
Biological Psychiatry.
729-737.
2013
-
Systemic Administration of an Alpha-7 Nicotinic Acetylcholine Agonist Reverses Neuropathic Pain in Male Sprague Dawley Rats.
Journal of Pain.
1162-1171.
2012
-
IL-1RA injected intra-cisterna magna confers extended prophylaxis against lipopolysaccharide-induced neuroinflammatory and sickness responses.
Journal of Neuroimmunology.
33-39.
2012
-
Prior exposure to repeated morphine potentiates mechanical allodynia induced by peripheral inflammation and neuropathy.
Brain, Behavior, and Immunity.
1256-1264.
2012
-
Repositioning Antimicrobial Agent Pentamidine as a Disruptor of the Lateral Interactions of Transmembrane Domain 5 of EBV Latent Membrane Protein 1.
PLoS One.
2012
-
Intracisternal Interleukin-1 Receptor Antagonist Prevents Postoperative Cognitive Decline and Neuroinflammatory Response in Aged Rats.
The Journal of Neuroscience.
14641-14648.
2012
-
Sex and estradiol influence glial pro-inflammatory responses to lipopolysaccharide in rats.
Psychoneuroendocrinology.
1688-1699.
2012
-
Short- and long-term consequences of stressor controllability in adolescent rats.
Behavioural Brain Research.
278-284.
2012
-
Harnessing pain heterogeneity and RNA transcriptome to identify blood-based pain biomarkers: a novel correlational study design and bioinformatics approach in a graded chronic constriction injury model.
Journal of Neurochemistry.
976-994.
2012
-
Opioid Activation of Toll-Like Receptor 4 Contributes to Drug Reinforcement.
The Journal of Neuroscience.
11187-11200.
2012
-
Aging-related changes in neuroimmune-endocrine function: Implications for hippocampal-dependent cognition.
Hormones and Behaviour.
219-227.
2012
-
Acute Neuroimmune Modulation Attenuates the Development of Anxiety-Like Freezing Behavior in an Animal Model of Traumatic Brain Injury.
Journal of Neurotrauma.
1886-1897.
2012
-
(+)-Naloxone, an Opioid-Inactive Toll-Like Receptor 4 Signaling Inhibitor, Reverses Multiple Models of Chronic Neuropathic Pain in Rats.
Journal of Pain.
498-506.
2012
-
Morphine activates neuroinflammation in a manner parallel to endotoxin.
Proceedings of the National Academy of Sciences of USA.
6325-6330.
2012
-
Commentary on Landry et al.: "Propentofylline, a CNS glial modulator, does not decrease pain in post-herpetic neuralgia patients: In vitro evidence for differential responses in human and rodent microglia and macrophages".
Experimental Neurology.
351-353.
2012
- Microglia attenuate the opioid-induced depression of preBotzinger Complex (preBotC) inspiratory rhythm in vitro via a TLR4-independent pathway. The FASEB Journal. 2012
-
Toll-like receptors in chronic pain.
Experimental Neurology.
316-329.
2012
-
Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice.
British Journal of Pharmacology.
1319-1329.
2012
-
Tetracyclines and pain.
Naunyn-Schmiedebergs Archives of Pharmacology.
225-241.
2012
-
Intraneural dexamethasone applied simultaneously to rat sciatic nerve constriction delays the development of hyperalgesia and allodynia.
Neuroscience Letters.
20-23.
2012
-
Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses.
Brain, Behavior, and Immunity.
337-345.
2012
-
Post-conditioning experience with acute or chronic inflammatory pain reduces contextual fear conditioning in the rat.
Behavioural Brain Research.
361-368.
2012
-
Activation of the medial prefrontal cortex by escapable stress is necessary for protection against subsequent inescapable stress-induced potentiation of morphine conditioned place preference.
European Journal of Neuroscience.
160-165.
2012
-
Indwelling Supradural Catheters for Induction of Facial Allodynia: Surgical Procedures, Application of Inflammatory Stimuli, and Behavioral Testing.
Methods in Molecular Biology.
99-107.
2012
-
Understanding chronic inflammatory and neuropathic pain.
Annals of the New York Academy of Sciences.
30-44.
2012
-
Unilateral T13 and L1 Dorsal Root Avulsion: Methods for a Novel Model of Central Neuropathic Pain.
Methods in Molecular Biology.
171-183.
2012
-
Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors.
Journal of Neuroimmunology.
53-60.
2011
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Uncontrollable, But Not Controllable, Stress Desensitizes 5-HT1A Receptors in the Dorsal Raphe Nucleus.
The Journal of Neuroscience.
14107-14115.
2011
-
Prior exposure to glucocorticoids potentiates lipopolysaccharide induced mechanical allodynia and spinal neuroinflammation.
Brain, Behavior, and Immunity.
1408-1415.
2011
-
Exploring the Neuroimmunopharmacology of Opioids: An Integrative Review of Mechanisms of Central Immune Signaling and Their Implications for Opioid Analgesia.
Pharmacological Reviews.
772-810.
2011
-
Safety Signals Mitigate the Consequences of Uncontrollable Stress Via a Circuit Involving the Sensory Insular Cortex and Bed Nucleus of the Stria Terminalis.
Biological Psychiatry.
458-464.
2011
-
An MD2 Hot-Spot-Mimicking Peptide that Suppresses TLR4-Mediated Inflammatory Response in vitro and in vivo.
ChemBioChem: a European journal of chemical biology.
1827-1831.
2011
-
Little Exercise, Big Effects: Reversing Aging and Infection-Induced Memory Deficits, and Underlying Processes.
The Journal of Neuroscience.
11578-11586.
2011
-
Naloxone-precipitated morphine withdrawal behavior and brain IL-1β expression: Comparison of different mouse strains.
Brain, Behavior, and Immunity.
1223-1232.
2011
-
Attenuation of microglial and IL-1 signaling protects mice from acute alcohol-induced sedation and/or motor impairment.
Brain, Behavior, and Immunity.
S155-S164.
2011
-
Stress- and glucocorticoid-induced priming of neuroinflammatory responses: Potential mechanisms of stress-induced vulnerability to drugs of abuse.
Brain, Behavior, and Immunity.
S21-S28.
2011
-
Voluntary wheel running produces resistance to inescapable stress-induced potentiation of morphine conditioned place preference.
Behavioural Brain Research.
378-381.
2011
-
Caudal Granular Insular Cortex Is Sufficient and Necessary for the Long-Term Maintenance of Allodynic Behavior in the Rat Attributable to Mononeuropathy.
The Journal of Neuroscience.
6317-6328.
2011
- Memory Impairments in Healthy Aging: Role of Aging-Induced Microglial Sensitization. Aging and Disease. 212-231. 2010
-
Counter-Regulation of Opioid Analgesia by Glial-Derived Bioactive Sphingolipids.
The Journal of Neuroscience.
15400-15408.
2010
-
Activation of the infralimbic cortex in a fear context enhances extinction learning.
Learning and Memory.
591-599.
2010
-
Role of the medial prefrontal cortex in coping and resilience.
Brain Research.
52-60.
2010
-
Pain Intensity and Duration Can Be Enhanced by Prior Challenge: Initial Evidence Suggestive of a Role of Microglial Priming.
Journal of Pain.
1004-1014.
2010
-
Application of a novel in silico high-throughput screen to identify selective inhibitors for protein-protein interactions.
Bioorganic and Medicinal Chemistry Letters.
5411-5413.
2010
-
SPINAL UPREGULATION OF GLUTAMATE TRANSPORTER GLT-1 BY CEFTRIAXONE: THERAPEUTIC EFFICACY IN A RANGE OF EXPERIMENTAL NERVOUS SYSTEM DISORDERS.
Neuroscience.
1888-1900.
2010
-
Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo.
Journal of Neuroimmunology.
181-184.
2010
-
Below Level Central Pain Induced by Discrete Dorsal Spinal Cord Injury.
Journal of Neurotrauma.
1697-1707.
2010
-
Intrathecal injection of an alpha seven nicotinic acetylcholine receptor agonist attenuates gp120-induced mechanical allodynia and spinal pro-inflammatory cytokine profiles in rats.
Brain, Behavior, and Immunity.
959-967.
2010
-
Selection, Preparation, and Evaluation of Small-Molecule Inhibitors of Toll-Like Receptor 4.
ACS Medicinal Chemistry Letters.
194-198.
2010
-
Toll-like receptor 4 in CNS pathologies.
Journal of Neurochemistry.
13-27.
2010
-
EVIDENCE THAT TRICYCLIC SMALL MOLECULES MAY POSSESS TOLL-LIKE RECEPTOR AND MYELOID DIFFERENTIATION PROTEIN 2 ACTIVITY.
Neuroscience.
551-563.
2010
-
PEGylation of interleukin-10 for the mitigation of enhanced pain states.
Journal of Biomedical Materials Research Part A.
1169-1179.
2010
-
POSSIBLE INVOLVEMENT OF TOLL-LIKE RECEPTOR 4/MYELOID DIFFERENTIATION FACTOR-2 ACTIVITY OF OPIOID INACTIVE ISOMERS CAUSES SPINAL PROINFLAMMATION AND RELATED BEHAVIORAL CONSEQUENCES.
Neuroscience.
880-893.
2010
-
Release of Plasmid DNA-Encoding IL-10 from PLGA Microparticles Facilitates Long-Term Reversal of Neuropathic Pain Following a Single Intrathecal Administration.
Pharmaceutical Research.
841-854.
2010
-
Neonatal Escherichia coli infection alters glial, cytokine, and neuronal gene expression in response to acute amphetamine in adolescent rats.
Neuroscience Letters.
52-57.
2010
-
Neonatal bacterial infection alters fever to live and simulated infections in adulthood.
Psychoneuroendocrinology.
369-381.
2010
-
Enduring consequences of early-life infection on glial and neural cell genesis within cognitive regions of the brain.
Brain, Behavior, and Immunity.
329-338.
2010
-
BEHAVIORAL CONTROL OVER SHOCK BLOCKS BEHAVIORAL AND NEUROCHEMICAL EFFECTS OF LATER SOCIAL DEFEAT.
Neuroscience.
1031-1038.
2010
-
5-Hydroxytryptamine 2C Receptors in the Basolateral Amygdala Are Involved in the Expression of Anxiety After Uncontrollable Traumatic Stress.
Biological Psychiatry.
339-345.
2010
-
IL-1RA blocks E. coli-induced suppression of Arc and long-term memory in aged F344 x BN F1 rats.
Brain, Behavior, and Immunity.
254-262.
2010
-
EVIDENCE THAT INTRATHECAL MORPHINE-3-GLUCURONIDE MAY CAUSE PAIN ENHANCEMENT VIA TOLL-LIKE RECEPTOR 4/MD-2 AND INTERLEUKIN-1β.
Neuroscience.
569-583.
2010
-
A novel method for modeling facial allodynia associated with migraine in awake and freely moving rats.
Journal of Neuroscience Methods.
236-245.
2010
-
Evidence that opioids may have toll-like receptor 4 and MD-2 effects.
Brain, Behavior, and Immunity.
83-95.
2010
-
Prior exposure to glucocorticoids sensitizes the neuroinflammatory and peripheral inflammatory responses to E. coli lipopolysaccharide.
Brain, Behavior, and Immunity.
19-30.
2010
-
EVIDENCE FOR A ROLE OF HEAT SHOCK PROTEIN-90 IN TOLL LIKE RECEPTOR 4 MEDIATED PAIN ENHANCEMENT IN RATS.
Neuroscience.
1821-1832.
2009
-
PEGylation of brain-derived neurotrophic factor for preserved biological activity and enhanced spinal cord distribution.
Journal of Biomedical Materials Research Part A.
719-729.
2009
-
Enduring Reversal of Neuropathic Pain by a Single Intrathecal Injection of Adenosine 2A Receptor Agonists: A Novel Therapy for Neuropathic Pain.
The Journal of Neuroscience.
14015-14025.
2009
-
The "Toll" of Opioid-Induced Glial Activation: Improving the Clinical Efficacy of Opioids by Targeting Glia.
Trends in Pharmacological Sciences.
581-591.
2009
-
Immunological priming potentiates non-viral anti-inflammatory gene therapy treatment of neuropathic pain.
Gene Therapy (Basingstoke).
1210-1222.
2009
-
Comment on: Excessive opioid use and the development of chronic migraine.
Pain.
262-263.
2009
-
Immunogenicity of intrathecal plasmid gene delivery: cytokine release and effects on transgene expression.
Journal of Gene Medicine.
782-790.
2009
-
Medial prefrontal cortical activation modulates the impact of controllable and uncontrollable stressor exposure on a social exploration test of anxiety in the rat..
Stress: the International Journal on the Biology of Stress.
445-450.
2009
-
Selective activation of dorsal raphe nucleus-projecting neurons in the ventral medial prefrontal cortex by controllable stress.
European Journal of Neuroscience.
1111-1116.
2009
-
The cortical innate immune response increases local neuronal excitability leading to seizures.
Brain: a journal of neurology.
2478-2486.
2009
-
Characterization of the sickness response in young and aging rats following E. coli infection.
Brain, Behavior, and Immunity.
450-454.
2009
-
The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine release.
Brain, Behavior, and Immunity.
492-497.
2009
-
Long-term control of neuropathic pain in a non-viral gene therapy paradigm.
Gene Therapy (Basingstoke).
470-475.
2009
-
A Peptide Antagonist of the TLR4-MD2 Interaction.
ChemBioChem: a European journal of chemical biology.
645-649.
2009
-
The Medial Prefrontal Cortex Regulates the Differential Expression of Morphine-Conditioned Place Preference Following a Single Exposure to Controllable or Uncontrollable Stress.
Neuropsychopharmacology.
834-843.
2009
-
Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast).
Brain, Behavior, and Immunity.
240-250.
2009
-
Anti-inflammatory cytokine gene therapy decreases sensory and motor dysfunction in experimental Multiple Sclerosis: MOG-EAE behavioral and anatomical symptom treatment with cytokine gene therapy.
Brain, Behavior, and Immunity.
92-100.
2009
-
Intrathecal Injection of Naked Plasmid DNA Provides Long-term Expression of Secreted Proteins.
Molecular Therapy.
88-94.
2009
-
Pathological and protective roles of glia in chronic pain.
Nature Reviews Neuroscience.
23-36.
2009
-
Time course of hippocampal IL-1 β and memory consolidation impairments in aging rats following peripheral infection.
Brain, Behavior, and Immunity.
46-54.
2009
-
The Sensory Insular Cortex Mediates the Stress-Buffering Effects of Safety Signals But Not Behavioral Control.
The Journal of Neuroscience.
13703-13711.
2008
-
The role of prior stressor controllability and the dorsal raphe nucleus in sucrose preference and social exploration.
Behavioural Brain Research.
87-93.
2008
-
Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia.
Brain, Behavior, and Immunity.
1248-1256.
2008
-
Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia.
Brain, Behavior, and Immunity.
1178-1189.
2008
-
Glia in pathological pain: A role for fractalkine.
Journal of Neuroimmunology.
113-120.
2008
-
Activation of the ventral medial prefrontal cortex during an uncontrollable stressor reproduces both the immediate and long-term protective effects of behavioral control.
Neuroscience.
1178-1186.
2008
-
Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4).
European Journal of Neuroscience.
20-29.
2008
-
Early-life infection leads to altered BDNF and IL-1β mRNA expression in rat hippocampus following learning in adulthood.
Brain, Behavior, and Immunity.
451-455.
2008
- Modeling facial allodynia associated with migraine in awake & freely moving rats. Headache. S61-S62. 2008
-
Bacterial infection early in life protects against stressor-induced depressive-like symptoms in adult rats.
Psychoneuroendocrinology.
261-269.
2008
-
Role of the ventral medial prefrontal cortex in mediating behavioral control-induced reduction of later conditioned fear.
Learning and Memory.
84-87.
2008
-
Prostaglandins are necessary and sufficient to induce contextual fear learning impairments after interleukin-1 beta injections into the dorsal hippocampus.
Neuroscience.
754-763.
2007
-
Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward..
The Scientific World Journal.
98-111.
2007
-
"Listening" and "talking" to neurons: Implications of immune activation for pain control and increasing the efficacy of opioids.
Brain Research Reviews.
148-169.
2007
-
A novel immune-to-CNS communication pathway: Cells of the meninges surrounding the spinal cord CSF space produce proinflammatory cytokines in response to an inflammatory stimulus.
Brain, Behavior, and Immunity.
711-718.
2007
-
Ibudilast (AV-411): a new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes.
Expert Opinion on Investigational Drugs.
935-950.
2007
-
Immune and glial regulation of pain.
Brain, Behavior, and Immunity.
519-521.
2007
-
Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120.
Brain, Behavior, and Immunity.
660-667.
2007
-
Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats.
Brain, Behavior, and Immunity.
686-698.
2007
-
Controllable versus uncontrollable stressors bi-directionally modulate conditioned but not innate fear.
Neuroscience.
1495-1503.
2007
-
Stress-induced glucocorticoids suppress the antisense molecular regulation of FGF-2 expression.
Psychoneuroendocrinology.
376-384.
2007
-
The effects of a single exposure to uncontrollable stress on the subsequent conditioned place preference responses to oxycodone, cocaine, and ethanol in rats.
Psychopharmacology.
909-917.
2007
-
The effects of a single session of inescapable tailshock on the subsequent locomotor response to brief footshock and cocaine administration in rats.
Psychopharmacology.
899-907.
2007
-
Characterization of the temporo-spatial effects of chronic bilateral intrahippocampal cannulae on interleukin-1 beta.
Journal of Neuroscience Methods.
265-272.
2007
-
A role for G protein-coupled receptor kinase 2 in mechanical allodynia.
European Journal of Neuroscience.
1696-1704.
2007
-
Differential effects of neonatal handling on early life infection-induced alterations in cognition in adulthood.
Brain, Behavior, and Immunity.
332-342.
2007
-
Expression of fibroblast growth factor-2 and brain-derived neurotrophic factor mRNA in the medial prefrontal cortex and hippocampus after uncontrollable or controllable stress.
Neuroscience.
1219-1228.
2007
-
Glia as the "bad guys": Implications for improving clinical pain control and the clinical utility of opioids.
Brain, Behavior, and Immunity.
131-146.
2007
-
Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses.
Brain, Behavior, and Immunity.
47-59.
2007
- Opioid-induced glial activation via a non-classical opioid receptor: clinical implications & the search for the target. Neuron Glia Biology. S16-S16. 2007
-
Previous experience with behavioral control over stress blocks the behavioral and dorsal raphe nucleus activating effects of later uncontrollable stress: Role of the ventral medial prefrontal cortex.
The Journal of Neuroscience.
13264-13272.
2006
-
Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain.
Pain.
294-308.
2006
-
Spinal cord glia and interleukin-1 do not appear to mediate persistent allodynia induced by intramuscular acidic saline in rats.
Journal of Pain.
757-767.
2006
-
Mediation of chronic pain: Not by neurons alone.
Pain.
1-2.
2006
-
The role of glucocorticoids in the uncontrollable stress-induced potentiation of nucleus accumbens shell dopamine and conditioned place preference responses to morphine.
Psychoneuroendocrinology.
653-663.
2006
-
ITRs Necessary for IL-10 Encoding Naked Plasmid Induced Reversal of Chronic Pain State in Rat.
Molecular Therapy.
S100-S100.
2006
-
In Vivo Over-Expression of Fractalkine, a Putative Neuron-to-Glia Signal, To Characterize Underlying Mechanisms of Neuropathic Pain.
Molecular Therapy.
S100-S100.
2006
-
Maternal care modulation of neonatal infection-facilitated cognitive impairment in adulthood.
Frontiers in Neuroendocrinology.
107-107.
2006
-
Peripheral infection and aging interact to impair hippocampal memory consolidation.
Neurobiology of Aging.
723-732.
2006
-
Plasmid DNA Encoding the Anti-Inflammatory Cytokine Gene, Interleukin-10 (IL-10) for Chronic Pain Control: Taking Advantage of Nuclear Scaffold/Matrix Attachment Regions.
Molecular Therapy.
S99-S99.
2006
-
mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging.
Neurobiology of Aging.
717-722.
2006
-
A behavioural characterization of neonatal infection-facilitated memory impairment in adult rats.
Behavioural Brain Research.
39-47.
2006
-
Behavioral control of the stressor modulates stress-induced changes in neurogenesis and fibroblast growth factor-2.
NeuroReport.
593-597.
2006
-
Rapid isolation of highly enriched and quiescent microglia from adult rat hippocampus: Immunophenotypic and functional characteristics.
Journal of Neuroscience Methods.
121-130.
2006
-
Mechanisms of Disease: neuropathic pain—a clinical perspective.
Nature Reviews Neurology.
95-106.
2006
-
Behavioral control, the medial prefrontal cortex, and resilience..
Dialogues in Clinical Neuroscience.
397-406.
2006
-
Intrathecal polymer-based interleukin-10*gene delivery for neuropathic pain.
Neuron Glia Biology.
293-308.
2006
-
The Persistent Sciatic Inflammatory Neuropathy (SIN) Rat Model of Neuropathic Pain Does Not Involve Small-Fiber Axon Damage.
Journal of neuropathic pain & symptom palliation.
41-47.
2006
-
The glial modulatory drug AV411 attenuates mechanical allodynia in rat models of neuropathic pain.
Neuron Glia Biology.
279-291.
2006
-
An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine.
European Journal of Neuroscience.
2775-2782.
2005
-
Glia: novel counter-regulators of opioid analgesia.
Trends in Neurosciences.
661-669.
2005
-
Involvement of spinal cord nuclear factor ÎşB activation in rat models of proinflammatory cytokine-mediated pain facilitation.
European Journal of Neuroscience.
1977-1986.
2005
-
Neonatal infection-induced memory impairment after lipopolysaccharide in adulthood is prevented via caspase-1 inhibition.
The Journal of Neuroscience.
8000-8009.
2005
-
Effect of number of tailshocks on learned helplessness and activation of serotonergic and noradrenergic neurons in the rat.
Behavioural Brain Research.
299-306.
2005
-
Expression of c-fos and BDNF mRNA in subregions of the prefrontal cortex of male and female rats after acute uncontrollable stress.
Brain Research.
90-99.
2005
-
Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation.
Pain.
71-83.
2005
-
Surgical and pharmacological suppression of glucocorticoids prevents the enhancement of morphine conditioned place preference by uncontrollable stress in rats.
Psychopharmacology.
409-417.
2005
-
Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10.
European Journal of Neuroscience.
2136-2148.
2005
-
Activation of the spinal cord complement cascade might contribute to mechanical allodynia induced by three animal models of spinal sensitization.
Journal of Pain.
174-183.
2005
-
Immune-to-brain communication dynamically modulates pain: Physiological and pathological consequences.
Brain, Behavior, and Immunity.
104-111.
2005
-
Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus.
Nature Neuroscience.
365-371.
2005
-
Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10.
Molecular Pain.
2005
-
Immune regulation of central nervous system functions: from sickness responses to pathological pain.
Journal of Internal Medicine.
139-155.
2005
-
Neonatal infection induces memory impairments following an immune challenge in adulthood.
Behavioral Neuroscience.
293-301.
2005
-
Central proinflammatory cytokines and pain enhancement.
NeuroSignals.
166-174.
2005
-
Stressor controllability and learned helplessness: The roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor.
Neuroscience and Biobehavioral Reviews.
829-841.
2005
-
Prefrontal cortex serotonin, stress, and morphine-induced nucleus accumbens dopamine.
NeuroReport.
2637-2641.
2004
-
Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats.
European Journal of Neuroscience.
2294-2302.
2004
-
BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1β administration.
Journal of Neuroimmunology.
119-126.
2004
-
A new function of the leptin receptor: mediation of the recovery from lipopolysaccharide-induced hypothermia.
The FASEB Journal.
1949-+.
2004
-
Fractakine (CX3CL1) and fractakine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions.
European Journal of Neuroscience.
1150-1160.
2004
-
Snake venom components enhance pain upon subcutaneous injection:: an initial examination of spinal cord mediators.
Pain.
65-76.
2004
-
Spinal gap junctions: Potential involvement in pain facilitation.
Journal of Pain.
392-405.
2004
-
A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine.
The Journal of Neuroscience.
7353-7365.
2004
-
Inescapable shock activates serotonergic neurons in all raphe nuclei of rat.
Behavioural Brain Research.
233-239.
2004
-
HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-1 (nNOS).
Pain.
517-530.
2004
-
Glial activation and pathological pain.
Neurochemistry International: the journal for the publication of cellular and molecular aspects of neurochemistry.
389-395.
2004
-
Peri-sciatic proinflammatory cytokines, reactive oxygen species, and complement induce mirror-image neuropathic pain in rats.
Pain.
299-309.
2004
- Spinal glial cells, glutamate, neurokinins, cytokines and nitric oxide mediate pain facilitation induced by Lys49 and Asp49 myotoxic phospholipases A2. Fundamental and Clinical Pharmacology. 58-58. 2004
-
Differential expression of 5HT-1A, α1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, γ-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus.
Journal of Comparative Neurology.
364-378.
2004
-
A method for measuring multiple cytokines from small samples.
Brain, Behavior, and Immunity.
274-280.
2004
- Spinal interleukin-10 (IL-10) gene therapy using viral and non-viral vectors controls inflammatory- and chronic constriction injury-induced pain states in rats. Molecular Therapy. S200-S201. 2004
-
Chemical lesion of the bed nucleus of the stria terminalis blocks the behavioral consequences of uncontrollable stress.
Behavioral Neuroscience.
443-448.
2004
-
Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide.
Pain.
180-191.
2004
-
Electrolytic lesions and pharmacological inhibition of the dorsal raphe nucleus prevent stressor potentiation of morphine conditioned place preference in rats.
Psychopharmacology.
191-198.
2004
-
Microinjection of urocortin 2 into the dorsal raphe nucleus activates serotonergic neurons and increases extracellular serotonin in the basolateral amygdala.
Neuroscience.
509-519.
2004
-
Sciatic inflammatory neuropathy in the rat: surgical procedures, induction of inflammation, and behavioral testing..
Methods in Molecular Medicine.
67-89.
2004
-
Stress potentiation of morphine-induced dopamine efflux in the nucleus accumbens shell is dependent upon stressor uncontrollability and is mediated by the dorsal raphe nucleus.
Neuroscience.
705-715.
2004
-
Stress potentiation of morphine-induced dopamine efflux in the nucleus accumbens shell is dependent upon stressor uncontrollability and is mediated by the dorsal raphe nucleus..
Neuroscience.
705-715.
2004
-
Stress-induced sensitization of the hypothalamic-pituitary adrenal axis is associated with alterations of hypothalamic and pituitary gene expression.
Neuroendocrinology: international journal for basic and clinical studies on neuroendocrine relationships.
252-263.
2004
-
The role of IL-1 beta in stress-induced sensitization of proinflammatory cytokine and corticosterone responses.
Neuroscience.
569-577.
2004
-
Further characterization of high mobility group box 1 (HMGB1) as a proinflammatory cytokine: central nervous system effects.
Cytokine.
254-265.
2003
-
Low doses of corticotropin-releasing hormone injected into the dorsal raphe nucleus block the behavioral consequences of uncontrollable stress.
Behavioural Brain Research.
55-64.
2003
-
Glia: A novel drug discovery target for clinical pain.
Nature Reviews Drug Discovery.
973-985.
2003
-
Stressor exposure produces long-term reductions in antigen-specific T and B cell responses.
Stress: the International Journal on the Biology of Stress.
259-267.
2003
-
When good pain turns bad.
Current Directions in Psychological Science.
232-236.
2003
-
Peripheral and central proinflammatory cytokine response to a severe acute stressor.
Brain Research.
123-132.
2003
-
Circulating cytokines and endotoxin are not necessary for the activation of the sickness or corticosterone response produced by peripheral E-coli challenge.
Journal of Applied Physiology.
1873-1882.
2003
-
Review: neuronal-glial interactions in central sensitization.
Seminars in Pain Medicine.
171-183.
2003
-
Serum cholesterol levels and stressor controllability in rats.
Physiology and Behavior.
757-760.
2003
-
Stressor controllability modulates stress-induced dopamine and serotonin efflux and morphine-induced serotonin efflux in the medial prefrontal cortex.
Neuropsychopharmacology.
1589-1596.
2003
-
Stressor controllability modulates stress-induced serotonin but not dopamine efflux in the nucleus accumbens shell.
Synapse (New York).
206-208.
2003
-
Inescapable shock induces resistance to the effects of dexamethasone.
Psychoneuroendocrinology.
481-500.
2003
- Corticotropin releasing hormone type 2 receptors in the dorsal raphe nucleus mediate the behavioral consequences of uncontrollable stress. The Journal of Neuroscience. 1019-1025. 2003
-
Effects of prior stress on LPS-induced cytokine and sickness responses.
American Journal of Physiology: Regulatory, Integrative and Comparative Physiology.
R422-R432.
2003
- Immune-to-central nervous system communication and its role in modulating pain and cognition: Implications for cancer and cancer treatment. Brain, Behavior, and Immunity. S125-S131. 2003
- Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats. The Journal of Neuroscience. 1026-1040. 2003
-
Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist.
Neuroscience.
847-853.
2003
- Glial proinflammatory cytokines mediate exaggerated pain states: Implications for clinical pain. Advances in Experimental Medicine and Biology. 1-21. 2003
-
Beyond neurons: Evidence that immune and glial cells contribute to pathological pain states.
Physiological Reviews.
981-1011.
2002
-
Blockade of alphal adrenoreceptors in the dorsal raphe nucleus prevents enhanced conditioned fear and impaired escape performance following uncontrollable stressor exposure in rats.
Behavioural Brain Research.
387-392.
2002
-
Memory for context is impaired by a post context exposure injection of interleukin-1 beta into dorsal hippocampus.
Behavioural Brain Research.
291-298.
2002
-
Prior stressor exposure sensitizes LPS-induced cytokine production.
Brain, Behavior, and Immunity.
461-476.
2002
-
Elevated IL-1 beta contributes to antibody suppression produced by stress.
Journal of Applied Physiology.
207-215.
2002
-
Prior stressor exposure primes the HPA axis.
Psychoneuroendocrinology.
353-365.
2002
-
The role of corticotropin-releasing hormone in the dorsal raphe nucleus in mediating the behavioral consequences of uncontrollable stress.
The Journal of Neuroscience.
1020-1026.
2002
-
Modulation of the locomotor properties of morphine and amphetamine by uncontrollable stress.
Pharmacology, Biochemistry and Behavior.
345-351.
2002
-
A new model of sciatic inflammatory neuritis (SIN): induction of unilateral and bilateral mechanical allodynia following acute unilateral peri-sciatic immune activation in rats.
Pain.
231-244.
2001
-
Systemic administration of CNI-1493, a p38 mitogen-activated protein kinase inhibitor, blocks intrathecal human immunodeficiency virus-1 gp120-induced enhanced pain states in rats.
Journal of Pain.
326-333.
2001
-
The role of the habenular complex in the elevation of dorsal raphe nucleus serotonin and the changes in the behavioral responses produced by uncontrollable stress.
Brain Research.
118-126.
2001
-
Sciatic inflammatory neuritis ⟨SIN⟩:: Behavioral allodynia is paralleled by peri-sciatic proinflammatory cytokine and superoxide production.
Journal of the Peripheral Nervous System.
111-129.
2001
-
Spinal cord glia: new players in pain.
Pain.
201-205.
2001
-
Glial activation: a driving force for pathological pain.
Trends in Neurosciences.
450-455.
2001
-
Staphylococcal enterotoxin B induces fever, brain c-Fos expression, and serum corticosterone in rats.
American Journal of Physiology: Regulatory, Integrative and Comparative Physiology.
R1434-R1439.
2001
-
Intrathecal HIV-1 envelope glycoprotein gp120 induces enhanced pain states mediated by spinal cord proinflammatory cytokines.
The Journal of Neuroscience.
2808-2819.
2001
- The contribution of the vagus nerve in interleukin-1β-induced fever is dependent on dose. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. R929-R934. 2001
-
Endogenous glucocorticoids play a positive regulatory role in the anti-keyhole limpet hemocyanin in vivo antibody response.
Journal of Immunology.
3813-3819.
2001
-
The immune system and memory consolidation:: a role for the cytokine IL-1β.
Neuroscience and Biobehavioral Reviews.
29-41.
2001
-
Effects of vagotomy on lipopolysaccharide-induced brain interleukin-1 beta protein in rats.
Autonomic Neuroscience: Basic and Clinical.
119-126.
2000
-
Subdiaphragmatic vagotomy blocks interleukin-1 beta-induced fever but does not reduce IL-1 beta levels in the circulation.
Autonomic Neuroscience: Basic and Clinical.
72-77.
2000
-
Subdiaphragmatic vagotomy does not block intraperitoneal lipopolysaccharide-induced fever.
Autonomic Neuroscience: Basic and Clinical.
83-87.
2000
-
Vagal immune-to-brain communication: a visceral chemosensory pathway.
Autonomic Neuroscience: Basic and Clinical.
49-59.
2000
-
Impaired escape performance and enhanced conditioned fear in rats following exposure to an uncontrollable stressor are mediated by glutamate and nitric oxide in the dorsal raphe nucleus.
Behavioural Brain Research.
33-41.
2000
-
The immune system as a sensory system: Implications for psychology.
Current Directions in Psychological Science.
98-102.
2000
-
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin.
Nature.
458-462.
2000
-
Vagotomy does not inhibit high dose lipopolysaccharide-induced interleukin-1 beta immunoreactivity in rat brain and pituitary gland.
Neuroscience Letters.
169-172.
2000
-
Human immunodeficiency virus-1 coat protein gp120 impairs contextual fear conditioning: a potential role in AIDS related learning and memory impairments.
Brain Research.
8-15.
2000
-
Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120.
Brain Research.
105-116.
2000
-
Timecourse and corticosterone sensitivity of the brain, pituitary, and serum interleukin-1β protein response to acute stress.
Brain Research.
193-201.
2000
- Effects of vagotomy on LPS-induced brain interleukin-1 beta protein in rats.. The FASEB Journal. A85-A85. 2000
- Subdiaphragmatic vagotomy blocks interleuxin-1 beta-induced fever without affecting increased circulating levels of this cytokine. The FASEB Journal. A85-A85. 2000
- Subdiaphragmatic vagotomy does not block intraperitoneal LPS-induced fever.. The FASEB Journal. A85-A85. 2000
-
Effects of vagotomy on serum endotoxin, cytokines, and corticosterone after intraperitoneal lipopolysaccharide.
American Journal of Physiology: Regulatory, Integrative and Comparative Physiology.
R331-R336.
2000
- Hyperalgesia and allodynia are produced by the HIV-1 glycoprotein, via spinal glial activation: Evidence for cytokine involvement.. European Journal of Neuroscience. 484-484. 2000
-
The pain of being sick: Implications of immune-to-brain communication for understanding pain.
Annual Review of Psychology.
29-57.
2000
-
Role of interleukin-1 beta in impairment of contextual fear conditioning caused by social isolation.
Behavioural Brain Research.
109-118.
1999
-
Long-term changes in mineralocorticoid and glucocorticoid receptor occupancy following exposure to an acute stressor.
Brain Research.
211-220.
1999
-
Acute stress may facilitate recovery from a subcutaneous bacterial challenge.
Neuroimmunomodulation.
344-354.
1999
-
A method for increasing the viability of the external portion of lumbar catheters placed in the spinal subarachnoid space of rats.
Journal of Neuroscience Methods.
81-86.
1999
-
Inescapable shock-induced potentiation of morphine analgesia in rats: Sites of action.
Behavioral Neuroscience.
795-803.
1999
-
Implications of immune-to-brain communication for sickness and pain.
Proceedings of the National Academy of Sciences of USA.
7710-7713.
1999
-
Dynamic regulation of the proinflammatory cytokine, interleukin-1 beta: Molecular biology for non-molecular biologists.
Life Sciences.
449-481.
1999
-
Activation of serotonin-immunoreactive cells in the dorsal raphe nucleus in rats exposed to an uncontrollable stressor.
Brain Research.
35-43.
1999
-
Bidirectional communication between the brain and the immune system: implications for behaviour.
Animal Behaviour.
741-751.
1999
- Interleukin-1β in immune cells of the abdominal vagus nerve:: a link between the immune and nervous systems?. The Journal of Neuroscience. 2799-2806. 1999
-
Opioid-dependent effects of inescapable shock on escape behavior and conditioned fear responding are mediated by the dorsal raphe nucleus.
Behavioural Brain Research.
153-167.
1999
- The effect of stressor controllability on stress-induced neuropeptide mRNA expression within the paraventricular nucleus of the hypothalamus. Journal of Neuroendocrinology. 121-128. 1999
- Dynamic regulation of proinflammatory cytokines. Advances in Experimental Medicine and Biology. 153-178. 1999
- Stress, learned helplessness, and brain interleukin-1 beta. Advances in Experimental Medicine and Biology. 235-249. 1999
-
The Impact of the Nonpeptide Corticotropin-Releasing Hormone Antagonist Antalarmin on Behavioral and Endocrine Responses to Stress* *This research was supported by NIMH Grant MH-50479 and the Undergraduate Research Opportunities Program at the University of Colorado at Boulder..
Endocrinology.
79-86.
1999
-
The impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stress.
Endocrinology.
79-86.
1999
-
Stressor controllability, anxiety, and serotonin.
Cognitive Therapy and Research.
595-613.
1998
-
Escapable and inescapable stress differentially alter extracellular levels of 5-HT in the basolateral amygdala of the rat.
Brain Research.
113-120.
1998
-
The long term acute phase-like responses that follow acute stressor exposure are blocked by alpha-melanocyte stimulating hormone.
Brain Research.
48-58.
1998
-
Interleukin-1 induces c-Fos immunoreactivity in primary afferent neurons of the vagus nerve.
Brain Research.
306-310.
1998
-
Acute stressor exposure both suppresses acquired immunity and potentiates innate immunity.
American Journal of Physiology: Regulatory, Integrative and Comparative Physiology.
R870-R878.
1998
-
Acute stressor exposure both suppresses acquired immunity and potentiates innate immunity..
American Journal of Physiology.
R870-R878.
1998
-
Selective effects of peripheral lipopolysaccharide administration on contextual and auditory-cue fear conditioning.
Brain, Behavior, and Immunity.
212-229.
1998
-
Uncontrollable stress potentiates morphine's rewarding properties.
Pharmacology, Biochemistry and Behavior.
655-664.
1998
-
Escapable and inescapable stress differentially and selectively alter extracellular levels of 5-HT in the ventral hippocampus and dorsal periaqueductal gray of the rat.
Brain Research.
12-22.
1998
-
Thermogenic and corticosterone responses to intravenous cytokines (IL-1β and TNF-α) are attenuated by subdiaphragmatic vagotomy.
Journal of Neuroimmunology.
134-141.
1998
- Neurocircuitry of conditioned inhibition of analgesia: Effects of amygdala, dorsal raphe, ventral medullary, and spinal cord lesions on antianalgesia in the rat. Behavioral Neuroscience. 360-378. 1998
- Characterization of brain interleukin-1 beta after LPS and acute stress.. The FASEB Journal. A262-A262. 1998
- Exposure to acute stress induces brain interleukin-1β protein in the rat. The Journal of Neuroscience. 2239-2246. 1998
-
Exposure to inescapable but not escapable shock increases extracellular levels of 5-HT in the dorsal raphe nucleus of the rat.
Brain Research.
115-120.
1998
-
Bacterial endotoxin induces fos immunoreactivity in primary afferent neurons of the vagus nerve.
Neuroimmunomodulation.
234-240.
1998
-
Cytokines for psychologists: Implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition.
Psychological Review.
83-107.
1998
-
The role of the vagus nerve in cytokine-to-brain communication.
Annals of the New York Academy of Sciences.
289-300.
1998
- Evidence that brief stress may induce the acute phase response in rats. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. R1998-R2004. 1997
-
Evidence that brief stress may induce the acute phase response in rats..
American Journal of Physiology.
R1998-R2004.
1997
- Inescapable shock-induced potentiation of morphine analgesia. Behavioral Neuroscience. 1105-1113. 1997
-
The case of the missing brain: Arguments for a role of brain to spinal cord pathways in pain facilitation.
Behavioral and Brain Sciences.
469-+.
1997
-
Subdiaphragmatic vagotomy does not prevent fever following intracerebroventricular prostaglandin E-2: further evidence for the importance of vagal afferents in immune-to-brain communication.
Brain Research.
240-243.
1997
- Inescapable shock-induced potentiation of morphine analgesia in rats: Involvement of opioid, GABAergic, and serotonergic mechanisms in the dorsal raphe nucleus. Behavioral Neuroscience. 816-824. 1997
-
Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat.
Pain.
225-235.
1997
-
Reversal of spinal cord non-opiate analgesia by conditioned anti-analgesia in the rat.
Pain.
237-247.
1997
-
Comparison of the effects of nucleus tractus solitarius and ventral medial medulla lesions on illness-induced and subcutaneous formalin-induced hyperalgesias.
Brain Research.
143-150.
1997
-
TNF-alpha-induced corticosterone elevation but not serum protein or corticosteroid binding globulin reduction is vagally mediated.
Brain Research Bulletin.
701-706.
1997
-
Vagal paraganglia bind biotinylated interleukin-1 receptor antagonist: A possible mechanism for immune-to-brain communication.
Brain Research Bulletin.
357-364.
1997
-
Associative and non-associative mechanisms of morphine analgesic tolerance are neurochemically distinct in the rat spinal cord.
Psychopharmacology.
248-255.
1996
-
Proinflammatory cytokines and specific immune function.
APS Journal.
234-236.
1996
-
Peripheral beta-adrenoreceptors and stress-induced hypercholesterolemia in rats.
Physiology and Behavior.
1307-1310.
1996
-
RU-486 blocks differentially suppressive effect of stress on in vivo anti-KLH immunoglobulin response.
American Journal of Physiology: Regulatory, Integrative and Comparative Physiology.
R1344-R1352.
1996
-
RU-486 blocks differentially suppressive effect of stress on in vivo anti-KLH immunoglobulin response..
American Journal of Physiology.
R1344-R1352.
1996
- Morphine-induced alterations in antibody levels: Receptor and immune mechanisms. Journal of Pharmacology and Experimental Therapeutics. 689-696. 1996
-
Macrophage stimulation reduces the cholesterol levels of stressed and unstressed rats.
Life Sciences.
1771-1776.
1996
- The cytokine network: Role of immune system in mediating the effects of stressors. International Journal of Psychology. 1074-1074. 1996
-
A LONG-TERM INCREASE IN BASAL LEVELS OF CORTICOSTERONE AND A DECREASE IN CORTICOSTEROID-BINDING GLOBULIN AFTER ACUTE STRESSOR EXPOSURE.
Endocrinology.
5336-5342.
1995
-
Immune activation: The role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states.
Pain.
289-302.
1995
-
THE ELEVATED PLUS-MAZE IS NOT SENSITIVE TO THE EFFECT OF STRESSOR CONTROLLABILITY IN RATS.
Pharmacology, Biochemistry and Behavior.
565-570.
1995
-
INTRACEREBROVENTRICULAR INTERLEUKIN-1 RECEPTOR ANTAGONIST BLOCKS THE ENHANCEMENT OF FEAR CONDITIONING AND INTERFERENCE WITH ESCAPE PRODUCED BY INESCAPABLE SHOCK.
Brain Research.
279-282.
1995
-
MECHANISMS OF TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) HYPERALGESIA.
Brain Research.
244-250.
1995
-
THE BENZODIAZEPINE RECEPTOR ANTAGONISTS FLUMAZENIL AND CGS8216 BLOCK THE ENHANCEMENT OF FEAR CONDITIONING AND INTERFERENCE WITH ESCAPE BEHAVIOR PRODUCED BY INESCAPABLE SHOCK.
Psychopharmacology.
250-258.
1995
-
CYTOKINE-TO-BRAIN COMMUNICATION - A REVIEW AND ANALYSIS OF ALTERNATIVE MECHANISMS.
Life Sciences.
1011-1026.
1995
-
THE DORSAL RAPHE NUCLEUS IS A SITE OF ACTION MEDIATING THE BEHAVIORAL-EFFECTS OF THE BENZODIAZEPINE RECEPTOR INVERSE AGONIST DMCM.
Behavioral Neuroscience.
759-766.
1995
-
8-OH-DPAT MICROINJECTED IN THE REGION OF THE DORSAL RAPHE NUCLEUS BLOCKS AND REVERSES THE ENHANCEMENT OF FEAR CONDITIONING AND INTERFERENCE WITH ESCAPE PRODUCED BY EXPOSURE TO INESCAPABLE SHOCK.
Behavioral Neuroscience.
404-412.
1995
-
STRESSED RATS FAIL TO EXPAND THE CD45RC(+)CD4(+) (TH1-LIKE) T-CELL SUBSET IN RESPONSE TO KLH - POSSIBLE INVOLVEMENT OF IFN-GAMMA.
Brain, Behavior, and Immunity.
101-112.
1995
-
BLOCKADE OF CYTOKINE-INDUCED CONDITIONED TASTE-AVERSION BY SUBDIAPHRAGMATIC VAGOTOMY - FURTHER EVIDENCE FOR VAGAL MEDIATION OF IMMUNE-BRAIN COMMUNICATION.
Neuroscience Letters.
163-166.
1995
-
BLOCKADE OF INTERLEUKIN-1 INDUCED HYPERTHERMIA BY SUBDIAPHRAGMATIC VAGOTOMY - EVIDENCE FOR VAGAL MEDIATION OF IMMUNE BRAIN COMMUNICATION.
Neuroscience Letters.
27-31.
1995
-
INTERLEUKIN-1-BETA INDUCED CORTICOSTERONE ELEVATION AND HYPOTHALAMIC NE DEPLETION IS VAGALLY MEDIATED.
Brain Research Bulletin.
605-610.
1995
-
STRESS-INDUCED REDUCTION IN THE RAT MIXED LYMPHOCYTE-REACTION IS DUE TO MACROPHAGES AND NOT TO CHANGES IN T-CELL PHENOTYPES.
Journal of Neuroimmunology.
45-52.
1995
-
PSYCHONEUROIMMUNOLOGY - THE INTERFACE BETWEEN BEHAVIOR, BRAIN, AND IMMUNITY.
American Psychologist.
1004-1017.
1994
-
ROUTE OF MORPHINE ADMINISTRATION MODULATES CONDITIONED ANALGESIC TOLERANCE AND HYPERALGESIA.
Pharmacology, Biochemistry and Behavior.
1029-1035.
1994
-
ILLNESS-INDUCED HYPERALGESIA IS MEDIATED BY A SPINAL NMDA NITRIC-OXIDE CASCADE.
Brain Research.
9-16.
1994
-
ILLNESS-INDUCED HYPERALGESIA IS MEDIATED BY SPINAL NEUROPEPTIDES AND EXCITATORY AMINO-ACIDS.
Brain Research.
17-24.
1994
-
A PERMISSIVE ROLE OF CORTICOSTERONE IN AN OPIOID FORM OF STRESS-INDUCED ANALGESIA - BLOCKADE OF OPIATE ANALGESIA IS NOT DUE TO STRESS-INDUCED HORMONE-RELEASE.
Brain Research.
19-29.
1994
-
CHARACTERIZATION OF CYTOKINE-INDUCED HYPERALGESIA.
Brain Research.
15-26.
1994
-
SUBCUTANEOUS FORMALIN PRODUCES CENTRIFUGAL HYPERALGESIA AT A NON-INJECTED SITE VIA THE NMDA NITRIC-OXIDE CASCADE.
Brain Research.
19-26.
1994
-
A HORSERADISH-PEROXIDASE STUDY OF PARALLEL THALAMOCORTICAL PROJECTIONS RESPONSIBLE FOR THE GENERATION OF MIDLATENCY AUDITORY-EVOKED POTENTIALS.
Brain Research.
65-75.
1994
-
NEUROCIRCUITRY OF ILLNESS-INDUCED HYPERALGESIA.
Brain Research.
283-299.
1994
-
MORPHINE-INDUCED DECREASES IN IN-VIVO ANTIBODY-RESPONSES.
Brain, Behavior, and Immunity.
24-36.
1994
- ACUTE AND CONDITIONED HYPERALGESIC RESPONSES TO ILLNESS. Pain. 227-234. 1994
-
THE NATURE OF CONDITIONED ANTI-ANALGESIA - SPINAL-CORD OPIATE AND ANTI-OPIATE NEUROCHEMISTRY.
Brain Research.
214-226.
1994
-
MODULATION OF THE IN-VIVO ANTIBODY-RESPONSE BY A BENZODIAZEPINE INVERSE AGONIST (DMCM) ADMINISTERED CENTRALLY OR PERIPHERALLY.
Physiology and Behavior.
1149-1154.
1993
- ANESTHESIA-INDUCED MODULATION OF IN-VIVO ANTIBODY-LEVELS - A STUDY OF PENTOBARBITAL, CHLORAL HYDRATE, METHOXYFLURANE, HALOTHANE, AND KETAMINE XYLAZINE. Anesthesia and Analgesia. 769-774. 1993
-
INTERLEUKIN-1 MEDIATES THE BEHAVIORAL HYPERALGESIA PRODUCED BY LITHIUM-CHLORIDE AND ENDOTOXIN.
Brain Research.
321-324.
1993
-
OPIOID AND NONOPIOID INTERACTIONS IN 2 FORMS OF STRESS-INDUCED ANALGESIA.
Pharmacology, Biochemistry and Behavior.
161-172.
1993
-
THE AMYGDALA IS NECESSARY FOR THE EXPRESSION OF CONDITIONED BUT NOT UNCONDITIONED ANALGESIA.
Behavioral Neuroscience.
402-405.
1993
-
THE ROLE OF THE AMYGDALA AND DORSAL RAPHE NUCLEUS IN MEDIATING THE BEHAVIORAL CONSEQUENCES OF INESCAPABLE SHOCK.
Behavioral Neuroscience.
377-388.
1993
-
BLOCKADE OF THE HYPOTHALAMIC-PITUITARY-ADRENAL RESPONSE TO STRESS BY INTRAVENTRICULAR-INJECTION OF DEXAMETHASONE - A METHOD FOR STUDYING THE STRESS-INDUCED PERIPHERAL EFFECTS OF GLUCOCORTICOIDS.
Psychoneuroendocrinology.
251-263.
1993
-
SPECIFIC CHANGES IN LYMPHOCYTE SUBPOPULATIONS - A POTENTIAL MECHANISM FOR STRESS-INDUCED IMMUNOMODULATION.
Journal of Neuroimmunology.
131-142.
1992
-
CONDITIONED INHIBITION OF ANALGESIA.
Learning and Behavior.
339-349.
1992
-
PARALLEL ACTIVATION OF MULTIPLE SPINAL OPIATE SYSTEMS APPEARS TO MEDIATE NONOPIATE STRESS-INDUCED ANALGESIAS.
Brain Research.
99-108.
1992
-
SPATIAL SUMMATION IN HUMAN THERMAL PAIN PERCEPTION - COMPARISON WITHIN AND BETWEEN DERMATOMES.
Pain.
197-202.
1992
-
DELTA OPIATE RECEPTORS MEDIATE TAIL-SHOCK INDUCED ANTINOCICEPTION AT SUPRASPINAL LEVELS.
Brain Research.
10-21.
1992
-
KAPPA OPIATE RECEPTORS MEDIATE TAIL-SHOCK INDUCED ANTINOCICEPTION AT SPINAL LEVELS.
Brain Research.
1-9.
1992
-
CHOLECYSTOKININ ANTIANALGESIA - SAFETY CUES ABOLISH MORPHINE ANALGESIA.
Science.
830-833.
1992
-
A 9L gliosarcoma transplantation model for studying adoptive immunotherapy into the brains of conscious rats..
Cell Transplantation.
307-312.
1992
-
CHARACTERIZATION OF INTRATHECAL VASOPRESSIN-INDUCED ANTINOCICEPTION, SCRATCHING BEHAVIOR, AND MOTOR SUPPRESSION.
Peptides.
17-25.
1992
-
TOTAL PLASMA-CHOLESTEROL LEVELS OF RATS ARE INCREASED FOLLOWING ONLY 3 SESSIONS OF TAILSHOCK.
Life Sciences.
945-950.
1992
-
CONDITIONED AND UNCONDITIONED STRESS-INDUCED ANALGESIA - STIMULUS PREEXPOSURE AND STIMULUS CHANGE.
Learning and Behavior.
295-304.
1991
-
COMPARISON OF HUMAN PAIN SENSATION AND FLEXION WITHDRAWAL EVOKED BY NOXIOUS RADIANT-HEAT.
Pain.
259-268.
1991
-
PHENYLEPHRINE-INDUCED ANTINOCICEPTION - INVESTIGATIONS OF POTENTIAL NEURAL AND ENDOCRINE BASES.
Brain Research.
273-284.
1990
-
ELECTRICAL-STIMULATION OF THE RAT VENTRAL MIDBRAIN ELICITS ANTINOCICEPTION VIA THE DORSOLATERAL FUNICULUS.
Brain Research.
333-348.
1989
-
ANTINOCICEPTION VS MOTOR EFFECTS OF INTRATHECAL VASOPRESSIN AS MEASURED BY 4 PAIN TESTS.
Brain Research.
1-11.
1988
-
THE DORSAL RAPHE NUCLEUS - A RE-EVALUATION OF ITS PROPOSED ROLE IN OPIATE ANALGESIA SYSTEMS.
Brain Research.
246-252.
1988
-
INHIBITION OF THE RESPONSES OF NEURONS IN THE RAT SPINAL-CORD TO NOXIOUS SKIN HEATING BY STIMULATION IN MIDBRAIN PERIAQUEDUCTAL GRAY OR LATERAL RETICULAR-FORMATION.
Brain Research.
266-277.
1986
-
MULTIPLE ENDOGENOUS OPIATE AND NONOPIATE ANALGESIA SYSTEMS - EVIDENCE OF THEIR EXISTENCE AND CLINICAL IMPLICATIONS.
Annals of the New York Academy of Sciences.
273-299.
1986
-
ROLE OF SPINAL-CORD NEUROPEPTIDES IN PAIN SENSITIVITY AND ANALGESIA - THYROTROPIN-RELEASING-HORMONE AND VASOPRESSIN.
Brain Research.
308-317.
1986
-
Potentiation of Systemic Morphine Analgesia in Humans by Proglumide, a Cholecystokinin Antagonist.
Anesthesia and Analgesia.
801???806-801???806.
1985
-
CHOLECYSTOKININ ANTAGONISTS SELECTIVELY POTENTIATE ANALGESIA INDUCED BY ENDOGENOUS OPIATES.
Brain Research.
181-190.
1985
-
POTENTIATION OF MORPHINE ANALGESIA BY THE CHOLECYSTOKININ ANTAGONIST PROGLUMIDE.
Brain Research.
169-180.
1985
-
SEXUAL RESPONSIVENESS AND ITS RELATIONSHIP TO VAGINAL STIMULATION-PRODUCED ANALGESIA IN THE RAT.
Brain Research.
309-315.
1985
-
SPINAL PAIN SUPPRESSION MECHANISMS MAY DIFFER FOR PHASIC AND TONIC PAIN.
Brain Research.
172-175.
1985
-
THE ENHANCEMENT OF OPIATE ANALGESIA AND THE POSSIBLE REVERSAL OF MORPHINE-TOLERANCE BY PROGLUMIDE.
Annals of the New York Academy of Sciences.
676-677.
1985
-
THE POTENTIATION OF MORPHINE-INDUCED INHIBITION OF SPINAL TRANSMISSION BY PROGLUMIDE, A PUTATIVE CHOLECYSTOKININ ANTAGONIST.
Annals of the New York Academy of Sciences.
660-662.
1985
-
A PSYCHOPHYSICAL ANALYSIS OF ACUPUNCTURE ANALGESIA.
Pain.
27-42.
1984
-
BILATERAL LESIONS OF THE DORSOLATERAL FUNICULUS OF THE CAT SPINAL-CORD - EFFECTS ON BASAL NOCICEPTIVE REFLEXES AND NOCICEPTIVE SUPPRESSION PRODUCED BY CHOLINERGIC ACTIVATION OF THE PONTINE PARABRACHIAL REGION.
Brain Research.
267-280.
1984
-
CATALEPTIC EFFECTS OF OPIATES FOLLOWING INTRATHECAL ADMINISTRATION.
Brain Research.
43-49.
1984
-
COMPARISON OF THE EFFECTS OF VENTRAL MEDULLARY LESIONS ON SYSTEMIC AND MICROINJECTION MORPHINE ANALGESIA.
Brain Research.
119-129.
1984
-
DIFFERENTIAL BEHAVIORAL-EFFECTS INDUCED BY INTRATHECAL MICROINJECTION OF OPIATES - COMPARISON OF CONVULSIVE AND CATALEPTIC EFFECTS PRODUCED BY MORPHINE, METHADONE, AND D-ALA2-METHIONINE-ENKEPHALINAMIDE.
Brain Research.
31-42.
1984
-
DORSOLATERAL FUNICULUS AND INTRASPINAL PATHWAYS MEDIATE VAGINAL STIMULATION-INDUCED SUPPRESSION OF NOCICEPTIVE RESPONDING IN RATS.
Brain Research.
59-65.
1984
-
EFFECT OF SPINAL-CORD LESIONS ON CONVULSIVE ACTIVITY INDUCED BY INTRATHECAL MORPHINE.
Brain Research.
337-345.
1984
-
EVIDENCE FOR INVOLVEMENT OF CHOLINOCEPTIVE CELLS OF THE PARABRACHIAL REGION IN ENVIRONMENTALLY INDUCED NOCICEPTIVE SUPPRESSION IN THE CAT.
Brain Research.
348-353.
1984
-
FEAR IS NOT CRITICAL TO CLASSICALLY-CONDITIONED ANALGESIA - THE EFFECTS OF PERIAQUEDUCTAL GRAY LESIONS AND ADMINISTRATION OF CHLORDIAZEPOXIDE.
Brain Research.
33-44.
1984
-
MUSCARINIC CHOLINERGIC MEDIATION OF OPIATE AND NON-OPIATE ENVIRONMENTALLY INDUCED ANALGESIAS.
Brain Research.
231-242.
1984
-
NON-OPIATE ANALGESIA INDUCED BY CARBACHOL MICROINJECTION INTO THE PONTINE PARABRACHIAL REGION OF THE CAT.
Brain Research.
263-283.
1984
- NON-SEROTONERGIC ORIGINS OF THE DORSOLATERAL FUNICULUS IN THE RAT VENTRAL MEDULLA. The Journal of Neuroscience. 757-766. 1984
-
NONSPECIFIC CONVULSIONS ARE INDUCED BY MORPHINE BUT NOT D-ALA2-METHIONINE-ENKEPHALINAMIDE AT CORTICAL SITES.
Brain Research.
51-59.
1984
-
OPIATE AND NON-OPIATE ANALGESIA INDUCED BY INESCAPABLE TAIL-SHOCK - EFFECTS OF DORSOLATERAL FUNICULUS LESIONS AND DECEREBRATION.
Brain Research.
325-336.
1984
-
POTENTIATION OF OPIATE ANALGESIA AND APPARENT REVERSAL OF MORPHINE-TOLERANCE BY PROGLUMIDE.
Science.
395-396.
1984
-
THE NEUROCHEMICAL BASIS OF FOOTSHOCK ANALGESIA - THE ROLE OF SPINAL-CORD SEROTONIN AND NOREPINEPHRINE.
Brain Research.
107-117.
1984
-
EVIDENCE FOR THE NEUROPEPTIDE CHOLECYSTOKININ AS AN ANTAGONIST OF OPIATE ANALGESIA.
Science.
310-312.
1983
-
OPIOID AND NON-OPIOID MECHANISMS OF FOOTSHOCK INDUCED ANALGESIA - ROLE OF THE SPINAL DORSOLATERAL FUNICULUS.
Brain Research.
139-144.
1983
-
THE NEURAL BASIS OF FOOTSHOCK ANALGESIA - THE EFFECT OF PERIAQUEDUCTAL GRAY LESIONS AND DECEREBRATION.
Brain Research.
317-324.
1983
-
THE NEURAL BASIS OF FOOTSHOCK ANALGESIA - THE ROLE OF SPECIFIC VENTRAL MEDULLARY NUCLEI.
Brain Research.
305-315.
1983
-
CLASSICAL-CONDITIONING OF FRONT PAW AND HIND PAW FOOTSHOCK INDUCED ANALGESIA (FSIA) - NALOXONE REVERSIBILITY AND DESCENDING PATHWAYS.
Brain Research.
119-132.
1982
-
FAILURE OF SPINAL-CORD SEROTONIN DEPLETION TO ALTER ANALGESIA ELICITED FROM THE PERIAQUEDUCTAL GRAY.
Brain Research.
373-386.
1982
-
FOOTSHOCK INDUCED ANALGESIA IS DEPENDENT NEITHER ON PITUITARY NOR SYMPATHETIC ACTIVATION.
Brain Research.
81-96.
1982
-
INVOLVEMENT OF SPINAL OPIOID SYSTEMS IN FOOTSHOCK-INDUCED ANALGESIA - ANTAGONISM BY NALOXONE IS POSSIBLE ONLY BEFORE INDUCTION OF ANALGESIA.
Brain Research.
309-316.
1982
-
OPIATE VS NON-OPIATE FOOTSHOCK INDUCED ANALGESIA (FSIA) - DESCENDING AND INTRA-SPINAL COMPONENTS.
Brain Research.
97-106.
1982
-
OPIATE VS NON-OPIATE FOOTSHOCK-INDUCED ANALGESIA (FSIA) - THE BODY REGION SHOCKED IS A CRITICAL FACTOR.
Brain Research.
299-308.
1982
-
IDENTIFICATION AND SOMATOTOPIC ORGANIZATION OF NUCLEI PROJECTING VIA THE DORSOLATERAL FUNICULUS IN RATS - A RETROGRADE TRACING STUDY USING HRP SLOW-RELEASE GELS.
Brain Research.
237-255.
1981
-
SOMATOTOPIC ORGANIZATION OF THE NUCLEUS RAPHE MAGNUS AND SURROUNDING BRAIN-STEM STRUCTURES AS REVEALED BY HRP SLOW-RELEASE GELS.
Brain Research.
1-15.
1980
-
HRP PELLETS AND SLOW-RELEASE GELS - 2 NEW TECHNIQUES FOR GREATER LOCALIZATION AND SENSITIVITY.
Brain Research.
595-601.
1979
-
An initial investigation of transcutaneous delivery of plasmid DNA encoding interleukin-10 for the treatment of psoriatic skin conditions..
Brain, Behavior, and Immunity.
903-913.
2024
Teaching
courses taught
-
NRSC 2100 - Introduction to Neuroscience
Primary Instructor - Spring 2018 / Spring 2019 / Spring 2022
Provides an introduction to fundamental concepts in neuroscience. The goal of this first course is to provide a strong foundation in neurobiology-cell biology, physiology of the neuronal membrane, interneuronal communication, neurotransmission, gross anatomy, and how the brain develops. Students will also learn principles of sensory systems functions. Recitation will reinforce lecture concepts through discussion of current research. -
NRSC 2101 - Topics in Neuroscience
Primary Instructor - Fall 2019 / Spring 2020 / Spring 2022 / Fall 2022 / Fall 2023 / Fall 2024
Provides students with the opportunity to focus on a specific area of Neuroscience in depth. May be repeated up to 6 total credit hours. -
NRSC 4011 - Senior Thesis
Primary Instructor - Spring 2018 / Spring 2019 / Fall 2019 / Spring 2021 / Fall 2022
Senior Thesis credits are available for students during the semester that they write and defend a departmental Honors Thesis. A neuroscience honors thesis must be based on an empirical research project that the student directs/participates in under guidance from a faculty member. Contact the neuroscience director for further information. -
NRSC 6602 - Behavioral Neuroscience Professional Skills Development
Primary Instructor - Spring 2018 / Spring 2019 / Fall 2019 / Spring 2020 / Spring 2021 / Spring 2022
Enrolled graduate students in the behavioral neuroscience program will be asked to prepare, present and receive feedback on scientific presentations of their own research or from review of a current research project. -
NRSC 7102 - Topics in Neuroscience
Primary Instructor - Spring 2020 / Spring 2022 / Fall 2022 / Fall 2023 / Fall 2024
Advanced seminar dealing with different specialized topics in neuroscience. May be repeated up to 9 total credit hours. Instructor consent required for students outside of the department.
Background
education and training
- Ph.D., Virginia Commonwealth University 1980
- B.S., University of California-Los Angeles 1976
awards and honors
International Activities
geographic focus
- Australia Country