research overview
- Professor Watkins’ research focuses on glial dysregulation of pain and opioid actions.
- Contact Info
Watkins, Linda R
Positions
- Distinguished Professor, Psychology and Neuroscience
Research Areas
Research
keywords
- glial dysregulation of pain and opioid actions
Publications
selected publications
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book
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chapter
- Drug Addiction. 299-318. 2014
- The future: new concepts and potential therapies. 341-356. 2013
- An awake behaving rat model for the study of dural inflammation-induced facial allodyna: a rat model relevant to migraine 2012
- Unilateral T13 and L1 Avulsion: methods for a novel model of central neuropathic pain 2012
- The role of the immune system in chronic pain comorbidities 2012
- The role of the medial prefrontal cortex in mediating resistance and vulnerability to the impact of adverse events 2009
- Glially driven enhancement of pain and its control by anti-inflammatory cytokines 2007
- Proinflammatory cytokines modulate neuropathic pain, opioid analgesia, and opioid tolerance 2007
- Neuroimmune Interactions and Pain: The Role of Immune and Glial Cells. 393-414. 2007
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Contribution of glia to pain processing in health and disease.
Handbook of Clinical Neurology.
309-323.
2006
- Glia and pain: Past, present and future 2005
- Multiple routes of action of interleukin-1 on the nervous system 2001
- Illness-induced hyperalgesia: mediators, mechanisms and implications 1999
- Neural, endocrine, and immune mechanisms of stress-induced immunomodulation 1998
- Stress and cytokine-brain interactions 1998
- Algesiometry in laboratory animals and man: current concepts and future directions 1989
- Interaction of cholecystokinin and opioids in pain modulation 1987
- BEHAVIORAL AND ELECTROPHYSIOLOGICAL INVESTIGATIONS OF OPIATE CHOLECYSTOKININ INTERACTIONS. Advances in pain research and therapy. 541-553. 1985
- Localization of the CNS sites mediating epileptiform activity elicited by morphine and endogenous opioids 1984
- MULTIPLE ENDOGENOUS OPIATE AND NONOPIATE ANALGESIA SYSTEMS. Advances in pain research and therapy. 253-276. 1984
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ORGANIZATION OF ENDOGENOUS OPIATE AND NON-OPIATE PAIN CONTROL-SYSTEMS.
Science.
1185-1192.
1982
- The role of endorphins in endogenous pain control systems 1981
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conference proceeding
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Glucocorticoids mediate stress-induced upregulation of the alarmin HMGB1 and downregulation of the inhibitory receptor CD200R1 in hippocampus and amygdala: A mechanism of neuroinflammatory priming.
Brain, Behavior, and Immunity.
E2-E3.
2019
-
Mycobacterium vaccae immunization protects aged rats from surgery-elicited neuroinflammation and cognitive dysfunction.
Brain, Behavior, and Immunity.
E36-E36.
2019
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Spinal cord injury perturbs circadian rhythms.
Brain, Behavior, and Immunity.
E39-E39.
2019
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The TLR2/4 antagonist (+)-naltrexone blocks contextual long-term memory deficits in experimental autoimmune encephalitis and associated neuroinflammation in hippocampus.
Brain, Behavior, and Immunity.
E34-E35.
2019
- Immunization with Mycobacterium vaccae induces an anti-inflammatory milieu in the CNS: attenuation of stress-induced microglial priming, alarmins and anxiety-like behavior 2018
- Improved Quality of Life in Dogs with OA After Intra-Articular XT-150 hIL-10v Plasmid DNA. Molecular Therapy. 195-195. 2017
- XT-101 PLGA/Human IL-10v Plasmid Promotes Improved Quality of Life in Companion Dogs with Osteoarthritis. Molecular Therapy. 144-144. 2017
- . Previous Inescapable Stress Interferes with the Immunizing, but not the Acute, Effect of Later Escapable Stressors. Society for Neuroscience 2017
- A neuroimmune basis for chronic pain in a rat model of Gulf War Illness 2017
- Diurnal variation of the effect of an acute stressor on an anxiety-like behavior 2017
- Evaluating Stressor Controllability Effects in Female Rats 2017
- Exposure to an acute stressor disinhibits microglia via down-regulation of CD200R: a mechanism of neuroinflammatory and microglial priming. 2017
- Investigating the fear-reducing effects of controllable stress with a robust activity marking system. 2017
- S.J. High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory. 2017
- Immune and glial involvement in physiological and pathological exaggerated pain states. 369-385. 2002
- The neurobiology of stressor controllability. 41-56. 1998
- Vagal afferent nerve mediates immune signals to the brain. Taniguchi Symposia on Brain Sciences. 143-151. 1998
- Neural, endocrine, and immune mechanisms of stress-induced immunomodulation. 175-185. 1996
- Stress and cytokine-brain interactions. 187-194. 1996
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Glucocorticoids mediate stress-induced upregulation of the alarmin HMGB1 and downregulation of the inhibitory receptor CD200R1 in hippocampus and amygdala: A mechanism of neuroinflammatory priming.
Brain, Behavior, and Immunity.
E2-E3.
2019
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journal article
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Caudal Granular Insular Cortex to Somatosensory Cortex I: A Critical Pathway for the Transition of Acute to Chronic Pain..
Journal of Neuroscience.
2026
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Reordering neuroimmune signaling to prevent and resolve chronic pain.
Pain.
S19-S22.
2025
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An initial investigation of transcutaneous delivery of plasmid DNA encoding interleukin-10 for the treatment of psoriatic skin conditions.
Brain, Behavior, and Immunity.
903-913.
2025
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Prevention and reversal of neuropathic pain by near-infrared photobiomodulation therapy in male and female rats.
Physiology and Behavior.
2024
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Corrigendum to " Intrathecal non-viral interleukin-10 gene therapy ameliorates neuropathic pain as measured by both classical static allodynia and a novel supra-spinally mediated pain assay, the Two-Arm Rodent Somatosensory (TARS) task" " [Brain Behav. Immun. 111 (2023) 177-185] - 185].
Brain, Behavior, and Immunity.
406-406.
2024
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Microglia in neuroimmunopharmacology and drug addiction.
Molecular Psychiatry.
2024
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Use of adeno-associated viruses for transgenic modulation of microglia structure and function: A review of technical considerations and challenges.
Brain, Behavior, and Immunity.
368-379.
2024
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Interleukin-1beta and inflammasome expression in spinal cord following chronic constriction injury in male and female rats.
Brain, Behavior, and Immunity.
157-168.
2024
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Voluntary wheel running prevents formation of membrane attack complexes and myelin degradation after peripheral nerve injury.
Brain, Behavior, and Immunity.
419-431.
2024
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Combining RNAscope and immunohistochemistry to visualize inflammatory gene products in neurons and microglia.
Frontiers in Molecular Neuroscience.
2023
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Intrathecal non-viral interleukin-10 gene therapy ameliorates neuropathic pain as measured by both classical static allodynia and a novel supra-spinally mediated pain assay, the Two-Arm Rodent Somatosensory (TARS) task.
Brain, Behavior, and Immunity.
177-185.
2023
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Toll-like receptor 4 antagonists reduce cocaine-primed reinstatement of drug seeking.
Psychopharmacology.
1587-1600.
2023
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Mechanisms of microglia-mediated synapse turnover and synaptogenesis.
Progress in Neurobiology.
2022
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Involvement of TLR2-TLR4, NLRP3, and IL-17 in pain induced by a novel Sprague-Dawley rat model of experimental autoimmune encephalomyelitis.
Frontiers in Pain Research.
2022
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T cell transgressions: tales of T cell form and function in diversedisease states.
International Reviews of Immunology.
475-516.
2022
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Suppression of active phase voluntary wheel running in male rats by unilateral chronic constriction injury: Enduring therapeutic effects of a brief treatment of morphine combined with TLR4 or P2X7 antagonists.
Journal of Neuroscience Research.
265-277.
2022
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Aging and miR-155 in mice influence survival and neuropathic pain after spinal cord injury.
Brain, Behavior, and Immunity.
365-370.
2021
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Nicotine and its metabolite cotinine target MD2 and inhibit TLR4 signaling.
The Innovation.
2021
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Toll -like receptor 2 and 4 antagonism for the treatment of experimental autoimmune encephalomyelitis (EAE)-related pain.
Brain, Behavior, and Immunity.
80-95.
2021
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Postoperative cognitive dysfunction is made persistent with morphine treatment in aged rats.
Neurobiology of Aging.
214-224.
2021
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Autoimmune regulation of chronic pain.
PAIN Reports.
2021
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Experimental autoimmune encephalopathy (EAE)-induced hippocampal neuroinflammation and memory deficits are prevented with the non-opioid TLR2/TLR4 antagonist (+)-naltrexone.
Behavioural Brain Research.
2021
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Acute stress induces the rapid and transient induction of caspase-1, gasdermin D and release of constitutive IL-1 beta protein in dorsal hippocampus.
Brain, Behavior, and Immunity.
70-80.
2020
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Targeted interleukin-10 plasmid DNA therapy in the treatment of osteoarthritis: Toxicology and pain efficacy assessments.
Brain, Behavior, and Immunity.
155-166.
2020
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Acute stress induces chronic neuroinflammatory, microglial and behavioral priming: A role for potentiated NLRP3 inflammasome activation.
Brain, Behavior, and Immunity.
32-42.
2020
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Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents.
Pain.
2107-2118.
2020
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The behavioral and neurochemical effects of an inescapable stressor are time of day dependent.
Stress.
405-416.
2020
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TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes.
Neurobiology of Disease.
2019
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Lovastatin inhibits Toll-like receptor 4 signaling in microglia by targeting its co-receptor myeloid differentiation protein 2 and attenuates neuropathic pain.
Brain, Behavior, and Immunity.
432-444.
2019
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Oxycodone, fentanyl, and morphine amplify established neuropathic pain in male rats.
Pain.
2634-2640.
2019
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Microglia: Neuroimmune-sensors of stress.
Seminars in Cell and Developmental Biology.
176-185.
2019
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Glucocorticoids mediate stress induction of the alarmin HMGB1 and reduction of the microglia checkpoint receptor CD200R1 in limbic brain structures.
Brain, Behavior, and Immunity.
678-687.
2019
-
Methamphetamine Activates Toll-Like Receptor 4 to Induce Central Immune Signaling within the Ventral Tegmental Area and Contributes to Extracellular Dopamine Increase in the Nucleus Accumbens Shell.
ACS Chemical Neuroscience.
3622-3634.
2019
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Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling.
The FASEB Journal.
9577-9587.
2019
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Spinal Cord Injury in Rats Dysregulates Diurnal Rhythms of Fecal Output and Liver Metabolic Indicators.
Journal of Neurotrauma.
1923-1934.
2019
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A single peri-sciatic nerve administration of the adenosine 2A receptor agonist ATL313 produces long-lasting anti-allodynia and anti-inflammatory effects in male rats.
Brain, Behavior, and Immunity.
116-125.
2019
-
Circadian misalignment has differential effects on affective behavior following exposure to controllable or uncontrollable stress.
Behavioural Brain Research.
440-445.
2019
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Could Probiotics Be Used to Mitigate Neuroinflammation?.
ACS Chemical Neuroscience.
13-15.
2019
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Repeated Morphine Prolongs Postoperative Pain in Male Rats.
Anesthesia and Analgesia.
161-167.
2019
-
Mycobacterium vaccae immunization protects aged rats from surgery-elicited neuroinflammation and cognitive dysfunction.
Neurobiology of Aging.
105-114.
2018
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Spinal Cord Injury in Rats Disrupts the Circadian System.
eNeuro.
2018
-
Immunization with Mycobacterium vaccae induces an anti-inflammatory milieu in the CNS: Attenuation of stress-induced microglial priming, alarmins and anxiety-like behavior.
Brain, Behavior, and Immunity.
352-363.
2018
-
MicroRNA-124 and microRNA-146a both attenuate persistent neuropathic pain induced by morphine in male rats.
Brain Research.
9-11.
2018
-
Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats.
Brain, Behavior, and Immunity.
45-50.
2018
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A novel platform for in vivo detection of cytokine release within discrete brain regions.
Brain, Behavior, and Immunity.
18-22.
2018
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DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats.
Experimental Neurology.
125-131.
2018
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DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats..
Experimental Neurology.
125-131.
2018
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MicroRNAs: Roles in Regulating Neuroinflammation.
Neuroscientist.
221-245.
2018
-
Neuroinflammatory priming to stress is differentially regulated in male and female rats.
Brain, Behavior, and Immunity.
257-267.
2018
-
Behavioural and neural sequelae of stressor exposure are not modulated by controllability in females.
European Journal of Neuroscience.
959-967.
2018
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Dissecting the Innate Immune Recognition of Opioid Inactive Isomer (+)-Naltrexone Derived Toll-like Receptor 4 (TLR4) Antagonists.
Journal of Chemical Information and Modeling.
816-825.
2018
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Toll-like receptors and their role in persistent pain.
Pharmacology and Therapeutics.
145-158.
2018
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Post-stroke Intranasal (+)-Naloxone Delivery Reduces Microglial Activation and Improves Behavioral Recovery from Ischemic Injury.
eNeuro.
2018
-
Stress disinhibits microglia via down-regulation of CD200R: A mechanism of neuroinflammatory priming.
Brain, Behavior, and Immunity.
62-73.
2018
-
Sustained reversal of central neuropathic pain induced by a single intrathecal injection of adenosine A2A receptor agonists.
Brain, Behavior, and Immunity.
470-479.
2018
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Inhibition of a Descending Prefrontal Circuit Prevents Ketamine-Induced Stress Resilience in Females.
eNeuro.
2018
-
Innate immune signaling in the ventral tegmental area contributes to drug-primed reinstatement of cocaine seeking.
Brain, Behavior, and Immunity.
130-138.
2018
-
High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory.
Neurobiology of Aging.
88-101.
2017
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Opioid Self-Administration is Attenuated by Early-Life Experience and Gene Therapy for Anti-Inflammatory IL-10 in the Nucleus Accumbens of Male Rats.
Neuropsychopharmacology.
2128-2140.
2017
-
Exploring acute-to-chronic neuropathic pain in rats after contusion spinal cord injury.
Experimental Neurology.
46-54.
2017
-
Constriction of the buccal branch of the facial nerve produces unilateral craniofacial allodynia.
Brain, Behavior, and Immunity.
59-64.
2017
-
Supradural inflammatory soup in awake and freely moving rats induces facial allodynia that is blocked by putative immune modulators.
Brain Research.
87-94.
2017
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Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy.
Brain, Behavior, and Immunity.
49-54.
2017
- Mycobacterium vaccae induces an anti-inflammatory milieu in the CNS: effects on stress-induced neuroinflammation. Biological Psychiatry. 2017
- Spinal cord injury in rats disrupts bowel function 2017
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Nitroxidative Signaling Mechanisms in Pathological Pain.
Trends in Neurosciences.
862-879.
2016
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Stable, long-term, spatial memory in young and aged rats achieved with a one day Morris water maze training protocol.
Learning & memory (Cold Spring Harbor, N.Y.).
699-702.
2016
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Diminished circadian rhythms in hippocampal microglia may contribute to age-related neuroinflammatory sensitization.
Neurobiology of Aging.
102-112.
2016
-
Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury.
Brain, Behavior, and Immunity.
348-356.
2016
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HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia.
Cell reports.
1128-1140.
2016
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Stress-induced neuroinflammatory priming: A liability factor in the etiology of psychiatric disorders.
Neurobiology of Stress.
62-70.
2016
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Glial contributions to visceral pain: implications for disease etiology and the female predominance of persistent pain.
Translational Psychiatry.
2016
-
Activation of a Habenulo-Raphe Circuit Is Critical for the Behavioral and Neurochemical Consequences of Uncontrollable Stress in the Male Rat.
eNeuro.
2016
-
Prior voluntary wheel running attenuates neuropathic pain.
Pain.
2012-2023.
2016
-
The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming.
Journal of Neuroscience.
7946-7956.
2016
-
Glucocorticoids Mediate Short-Term High-Fat Diet Induction of Neuroinflammatory Priming, the NLRP3 Inflammasome, and the Danger Signal HMGB1.
eNeuro.
2016
-
The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: A role for the NLRP3 inflammasome.
Brain, Behavior, and Immunity.
215-224.
2016
-
Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation.
Proceedings of the National Academy of Sciences of the United States of America.
E3441-E3450.
2016
-
Stress-induced neuroinflammatory priming is time of day dependent.
Psychoneuroendocrinology.
82-90.
2016
-
Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as antagonists of toll-like receptor 4.
British Journal of Pharmacology.
856-869.
2016
-
Previous Ketamine Produces an Enduring Blockade of Neurochemical and Behavioral Effects of Uncontrollable Stress.
Journal of Neuroscience.
153-161.
2016
-
The danger-associated molecular pattern HMGB1 mediates the neuroinflammatory effects of methamphetamine.
Brain, Behavior, and Immunity.
99-108.
2016
-
DAT isn't all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling.
Molecular Psychiatry.
1525-1537.
2015
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NEUROINFLAMMATION IN THE NORMAL AGING HIPPOCAMPUS.
Neuroscience.
84-99.
2015
-
The therapeutic potential of interleukin-10 in neuroimmune diseases.
Neuropharmacology.
55-69.
2015
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(+)-Naltrexone is neuroprotective and promotes alternative activation in the mouse hippocampus after cardiac arrest/cardiopulmonary resuscitation.
Brain, Behavior, and Immunity.
115-122.
2015
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Stress sounds the alarmin: The role of the danger-associated molecular pattern HMGB1 in stress-induced neuroinflammatory priming.
Brain, Behavior, and Immunity.
1-7.
2015
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The permissive role of glucocorticoids in neuroinflammatory priming: mechanisms and insights.
Current Opinion in Endocrinology, Diabetes and Obesity.
300-305.
2015
-
Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists.
Journal of Medicinal Chemistry.
5038-5052.
2015
-
Adenosine 2A receptor agonism: A single intrathecal administration attenuates motor paralysis in experimental autoimmune encephalopathy in rats.
Brain, Behavior, and Immunity.
50-54.
2015
-
Opioid-Induced Central Immune Signaling: Implications for Opioid Analgesia.
Headache.
475-489.
2015
-
Alcohol-induced sedation and synergistic interactions between alcohol and morphine: A key mechanistic role for Toll-like receptors and MyD88-dependent signaling.
Brain, Behavior, and Immunity.
245-252.
2015
-
Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia.
Neurobiology of Aging.
1483-1495.
2015
-
Microglia inflammatory responses are controlled by an intrinsic circadian clock.
Brain, Behavior, and Immunity.
171-179.
2015
-
Pioglitazone rapidly reduces neuropathic pain through astrocyte and nongenomic PPAR-Îł mechanisms.
Pain.
469-482.
2015
-
Select steroid hormone glucuronide metabolites can cause toll-like receptor 4 activation and enhanced pain.
Brain, Behavior, and Immunity.
128-136.
2015
-
Stress Induces the Danger-Associated Molecular Pattern HMGB-1 in the Hippocampus of Male Sprague Dawley Rats: A Priming Stimulus of Microglia and the NLRP3 Inflammasome.
Journal of Neuroscience.
316-324.
2015
-
Targeting the Toll of Drug Abuse: The Translational Potential of Toll-Like Receptor 4.
CNS and Neurological Disorders - Drug Targets.
692-699.
2015
-
The role of hepatic and splenic macrophages in E. coli-induced memory impairments in aged rats.
Brain, Behavior, and Immunity.
60-67.
2015
-
ACTIVATION OF ADULT RAT CNS ENDOTHELIAL CELLS BY OPIOID-INDUCED TOLL-LIKE RECEPTOR 4 (TLR4) SIGNALING INDUCES PROINFLAMMATORY, BIOCHEMICAL, MORPHOLOGICAL, AND BEHAVIORAL SEQUELAE.
Neuroscience.
299-317.
2014
-
High-fat diet consumption disrupts memory and primes elevations in hippocampal IL-1β, an effect that can be prevented with dietary reversal or IL-1 receptor antagonism.
Brain, Behavior, and Immunity.
22-32.
2014
-
Glial TLR4 signaling does not contribute to opioid-induced depression of respiration.
Journal of applied physiology.
857-868.
2014
-
Learned stressor resistance requires extracellular signal-regulated kinase in the prefrontal cortex.
Frontiers in Behavioral Neuroscience.
2014
-
In vivo veritas: (+)-Naltrexone's actions define translational importance A letter in response to Skolnick et al. 'Translational potential of naloxone and naltrexone as TLR4 antagonists'.
Trends in Pharmacological Sciences.
432-433.
2014
-
Control over a stressor involves the posterior dorsal striatum and the act/outcome circuit.
European Journal of Neuroscience.
2352-2358.
2014
-
A concern on comparing 'apples' and 'oranges' when differences between microglia used in human and rodent studies go far, far beyond simply species: comment on Smith and Dragunow.
Trends in Neurosciences.
189-190.
2014
-
Pathological pain and the neuroimmune interface.
Nature Reviews Immunology.
217-231.
2014
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Systemic Administration of Propentofylline, Ibudilast, and (+)-Naltrexone Each Reverses Mechanical Allodynia in a Novel Rat Model of Central Neuropathic Pain.
Journal of Pain.
407-421.
2014
-
Reversal of Established Traumatic Brain Injury-Induced, Anxiety-Like Behavior in Rats after Delayed, Post-Injury Neuroimmune Suppression.
Journal of Neurotrauma.
487-497.
2014
-
Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus.
Psychoneuroendocrinology.
191-200.
2014
-
Suppression of Voluntary Wheel Running in Rats Is Dependent on the Site of Inflammation: Evidence for Voluntary Running as a Measure of Hind Paw-Evoked Pain.
Journal of Pain.
121-128.
2014
-
Discovery of a Novel Site of Opioid Action at the Innate Immune Pattern-Recognition Receptor TLR4 and its Role in Addiction.
International Review of Neurobiology.
129-163.
2014
-
Why is neuroimmunopharmacology crucial for the future of addiction research?.
Neuropharmacology.
218-227.
2014
-
Intrathecal injection of adenosine 2A receptor agonists reversed neuropathic allodynia through protein kinase (PK)A/PKC signaling.
Brain, Behavior, and Immunity.
112-122.
2013
-
Stress-induced glucocorticoids as a neuroendocrine alarm signal of danger.
Brain, Behavior, and Immunity.
1-6.
2013
-
Blocking toll-like receptor 2 and 4 signaling during a stressor prevents stress-induced priming of neuroinflammatory responses to a subsequent immune challenge.
Brain, Behavior, and Immunity.
112-121.
2013
-
Anxiogenic effects of brief swim stress are sensitive to stress history.
Progress in Neuro-Psychopharmacology and Biological Psychiatry.
17-22.
2013
-
Rifampin inhibits Toll-like receptor 4 signaling by targeting myeloid differentiation protein 2 and attenuates neuropathic pain.
The FASEB Journal.
2713-2722.
2013
-
A minocycline derivative reduces nerve injury-induced allodynia, LPS-induced prostaglandin E2 microglial production and signaling via toll-like receptors 2 and 4.
Neuroscience Letters.
157-162.
2013
-
Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain.
Brain, Behavior, and Immunity.
24-32.
2013
-
Effect of Chronic. Delivery of the Toll-like Receptor 4 Antagonist (+)-Naltrexone on Incubation of Heroin Craving.
Biological Psychiatry.
729-737.
2013
-
Systemic Administration of an Alpha-7 Nicotinic Acetylcholine Agonist Reverses Neuropathic Pain in Male Sprague Dawley Rats.
Journal of Pain.
1162-1171.
2012
-
IL-1RA injected intra-cisterna magna confers extended prophylaxis against lipopolysaccharide-induced neuroinflammatory and sickness responses.
Journal of Neuroimmunology.
33-39.
2012
-
Prior exposure to repeated morphine potentiates mechanical allodynia induced by peripheral inflammation and neuropathy.
Brain, Behavior, and Immunity.
1256-1264.
2012
-
Repositioning Antimicrobial Agent Pentamidine as a Disruptor of the Lateral Interactions of Transmembrane Domain 5 of EBV Latent Membrane Protein 1.
PLoS ONE.
2012
-
Intracisternal Interleukin-1 Receptor Antagonist Prevents Postoperative Cognitive Decline and Neuroinflammatory Response in Aged Rats.
Journal of Neuroscience.
14641-14648.
2012
-
Sex and estradiol influence glial pro-inflammatory responses to lipopolysaccharide in rats.
Psychoneuroendocrinology.
1688-1699.
2012
-
Short- and long-term consequences of stressor controllability in adolescent rats.
Behavioural Brain Research.
278-284.
2012
-
Harnessing pain heterogeneity and RNA transcriptome to identify blood-based pain biomarkers: a novel correlational study design and bioinformatics approach in a graded chronic constriction injury model.
Journal of Neurochemistry.
976-994.
2012
-
Opioid Activation of Toll-Like Receptor 4 Contributes to Drug Reinforcement.
Journal of Neuroscience.
11187-11200.
2012
-
Aging-related changes in neuroimmune-endocrine function: Implications for hippocampal-dependent cognition.
Hormones and Behavior.
219-227.
2012
-
Acute Neuroimmune Modulation Attenuates the Development of Anxiety-Like Freezing Behavior in an Animal Model of Traumatic Brain Injury.
Journal of Neurotrauma.
1886-1897.
2012
-
(+)-Naloxone, an Opioid-Inactive Toll-Like Receptor 4 Signaling Inhibitor, Reverses Multiple Models of Chronic Neuropathic Pain in Rats.
Journal of Pain.
498-506.
2012
-
Morphine activates neuroinflammation in a manner parallel to endotoxin.
Proceedings of the National Academy of Sciences of the United States of America.
6325-6330.
2012
-
Commentary on Landry et al.: "Propentofylline, a CNS glial modulator, does not decrease pain in post-herpetic neuralgia patients: In vitro evidence for differential responses in human and rodent microglia and macrophages".
Experimental Neurology.
351-353.
2012
- Microglia attenuate the opioid-induced depression of preBotzinger Complex (preBotC) inspiratory rhythm in vitro via a TLR4-independent pathway. The FASEB Journal. 2012
-
Toll-like receptors in chronic pain.
Experimental Neurology.
316-329.
2012
-
Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice.
British Journal of Pharmacology.
1319-1329.
2012
-
Tetracyclines and pain.
Naunyn-Schmiedeberg's Archives of Pharmacology.
225-241.
2012
-
Intraneural dexamethasone applied simultaneously to rat sciatic nerve constriction delays the development of hyperalgesia and allodynia.
Neuroscience Letters.
20-23.
2012
-
Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses.
Brain, Behavior, and Immunity.
337-345.
2012
-
Post-conditioning experience with acute or chronic inflammatory pain reduces contextual fear conditioning in the rat.
Behavioural Brain Research.
361-368.
2012
-
Activation of the medial prefrontal cortex by escapable stress is necessary for protection against subsequent inescapable stress-induced potentiation of morphine conditioned place preference.
European Journal of Neuroscience.
160-165.
2012
-
Indwelling Supradural Catheters for Induction of Facial Allodynia: Surgical Procedures, Application of Inflammatory Stimuli, and Behavioral Testing.
Methods in Molecular Biology.
99-107.
2012
-
Understanding chronic inflammatory and neuropathic pain.
Annals of the New York Academy of Sciences.
30-44.
2012
-
Unilateral T13 and L1 Dorsal Root Avulsion: Methods for a Novel Model of Central Neuropathic Pain.
Methods in Molecular Biology.
171-183.
2012
-
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Journal of the Peripheral Nervous System.
111-129.
2001
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Spinal cord glia: new players in pain.
Pain.
201-205.
2001
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Glial activation: a driving force for pathological pain.
Trends in Neurosciences.
450-455.
2001
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Staphylococcal enterotoxin B induces fever, brain c-Fos expression, and serum corticosterone in rats.
American Journal of Physiology. Regulatory Integrative and Comparative Physiology.
R1434-R1439.
2001
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Intrathecal HIV-1 envelope glycoprotein gp120 induces enhanced pain states mediated by spinal cord proinflammatory cytokines.
Journal of Neuroscience.
2808-2819.
2001
- The contribution of the vagus nerve in interleukin-1β-induced fever is dependent on dose. American Journal of Physiology. Regulatory Integrative and Comparative Physiology. R929-R934. 2001
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Endogenous glucocorticoids play a positive regulatory role in the anti-keyhole limpet hemocyanin in vivo antibody response.
Journal of Immunology.
3813-3819.
2001
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The immune system and memory consolidation: a role for the cytokine IL-1β.
Neuroscience and Biobehavioral Reviews.
29-41.
2001
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Effects of vagotomy on lipopolysaccharide-induced brain interleukin-1β protein in rats.
Autonomic Neuroscience: Basic and Clinical.
119-126.
2000
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Subdiaphragmatic vagotomy blocks interleukin-1 beta-induced fever but does not reduce IL-1 beta levels in the circulation.
Autonomic Neuroscience: Basic and Clinical.
72-77.
2000
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Subdiaphragmatic vagotomy does not block intraperitoneal lipopolysaccharide-induced fever.
Autonomic Neuroscience: Basic and Clinical.
83-87.
2000
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Vagal immune-to-brain communication: a visceral chemosensory pathway.
Autonomic Neuroscience: Basic and Clinical.
49-59.
2000
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Impaired escape performance and enhanced conditioned fear in rats following exposure to an uncontrollable stressor are mediated by glutamate and nitric oxide in the dorsal raphe nucleus.
Behavioural Brain Research.
33-41.
2000
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The immune system as a sensory system: Implications for psychology.
Current Directions in Psychological Science.
98-102.
2000
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Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin.
Nature.
458-462.
2000
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Vagotomy does not inhibit high dose lipopolysaccharide-induced interleukin-1β immunoreactivity in rat brain and pituitary gland.
Neuroscience Letters.
169-172.
2000
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Human immunodeficiency virus-1 coat protein gp120 impairs contextual fear conditioning: a potential role in AIDS related learning and memory impairments.
Brain Research.
8-15.
2000
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Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120.
Brain Research.
105-116.
2000
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Timecourse and corticosterone sensitivity of the brain, pituitary, and serum interleukin-1β protein response to acute stress.
Brain Research.
193-201.
2000
- Effects of vagotomy on LPS-induced brain interleukin-1 beta protein in rats.. The FASEB Journal. A85-A85. 2000
- Subdiaphragmatic vagotomy blocks interleuxin-1 beta-induced fever without affecting increased circulating levels of this cytokine. The FASEB Journal. A85-A85. 2000
- Subdiaphragmatic vagotomy does not block intraperitoneal LPS-induced fever.. The FASEB Journal. A85-A85. 2000
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Effects of vagotomy on serum endotoxin, cytokines, and corticosterone after intraperitoneal lipopolysaccharide.
American Journal of Physiology. Regulatory Integrative and Comparative Physiology.
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2000
- Hyperalgesia and allodynia are produced by the HIV-1 glycoprotein, via spinal glial activation: Evidence for cytokine involvement.. European Journal of Neuroscience. 484-484. 2000
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The pain of being sick: Implications of immune-to-brain communication for understanding pain.
Annual Review of Psychology.
29-57.
2000
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Role of interleukin-1 beta in impairment of contextual fear conditioning caused by social isolation.
Behavioural Brain Research.
109-118.
1999
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Long-term changes in mineralocorticoid and glucocorticoid receptor occupancy following exposure to an acute stressor.
Brain Research.
211-220.
1999
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A method for increasing the viability of the external portion of lumbar catheters placed in the spinal subarachnoid space of rats.
Journal of Neuroscience Methods.
81-86.
1999
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Inescapable shock-induced potentiation of morphine analgesia in rats: Sites of action.
Behavioral Neuroscience.
795-803.
1999
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Implications of immune-to-brain communication for sickness and pain.
Proceedings of the National Academy of Sciences of the United States of America.
7710-7713.
1999
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Dynamic regulation of the proinflammatory cytokine, interleukin-1β: Molecular biology for non-molecular biologists.
Life Sciences.
449-481.
1999
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Activation of serotonin-immunoreactive cells in the dorsal raphe nucleus in rats exposed to an uncontrollable stressor.
Brain Research.
35-43.
1999
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Bidirectional communication between the brain and the immune system: implications for behaviour.
Animal Behaviour.
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1999
- Interleukin-1β in immune cells of the abdominal vagus nerve: a link between the immune and nervous systems?. Journal of Neuroscience. 2799-2806. 1999
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Opioid-dependent effects of inescapable shock on escape behavior and conditioned fear responding are mediated by the dorsal raphe nucleus.
Behavioural Brain Research.
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1999
- The effect of stressor controllability on stress-induced neuropeptide mRNA expression within the paraventricular nucleus of the hypothalamus. Journal of Neuroendocrinology. 121-128. 1999
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Acute stress may facilitate recovery from a subcutaneous bacterial challenge.
NeuroImmunoModulation.
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1999
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- Stress, learned helplessness, and brain interleukin-1β. Advances in Experimental Medicine and Biology. 235-249. 1999
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The Impact of the Nonpeptide Corticotropin-Releasing Hormone Antagonist Antalarmin on Behavioral and Endocrine Responses to Stress* *This research was supported by NIMH Grant MH-50479 and the Undergraduate Research Opportunities Program at the University of Colorado at Boulder..
Endocrinology.
79-86.
1999
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The impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stress.
Endocrinology.
79-86.
1999
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Stressor controllability, anxiety, and serotonin.
Cognitive Therapy and Research.
595-613.
1998
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Escapable and inescapable stress differentially alter extracellular levels of 5-HT in the basolateral amygdala of the rat.
Brain Research.
113-120.
1998
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The long term acute phase-like responses that follow acute stressor exposure are blocked by alpha-melanocyte stimulating hormone.
Brain Research.
48-58.
1998
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Interleukin-1 induces c-Fos immunoreactivity in primary afferent neurons of the vagus nerve.
Brain Research.
306-310.
1998
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Acute stressor exposure both suppresses acquired immunity and potentiates innate immunity.
American Journal of Physiology. Regulatory Integrative and Comparative Physiology.
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1998
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Acute stressor exposure both suppresses acquired immunity and potentiates innate immunity..
American Journal of Physiology.
R870-R878.
1998
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Selective effects of peripheral lipopolysaccharide administration on contextual and auditory-cue fear conditioning.
Brain, Behavior, and Immunity.
212-229.
1998
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Uncontrollable stress potentiates morphine's rewarding properties.
Pharmacology Biochemistry and Behavior.
655-664.
1998
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Escapable and inescapable stress differentially and selectively alter extracellular levels of 5-HT in the ventral hippocampus and dorsal periaqueductal gray of the rat.
Brain Research.
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1998
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Thermogenic and corticosterone responses to intravenous cytokines (IL-1β and TNF-α) are attenuated by subdiaphragmatic vagotomy.
Journal of Neuroimmunology.
134-141.
1998
- Neurocircuitry of conditioned inhibition of analgesia: Effects of amygdala, dorsal raphe, ventral medullary, and spinal cord lesions on antianalgesia in the rat. Behavioral Neuroscience. 360-378. 1998
- Characterization of brain interleukin-1 beta after LPS and acute stress.. The FASEB Journal. A262-A262. 1998
- Exposure to acute stress induces brain interleukin-1β protein in the rat. Journal of Neuroscience. 2239-2246. 1998
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Exposure to inescapable but not escapable shock increases extracellular levels of 5-HT in the dorsal raphe nucleus of the rat.
Brain Research.
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1998
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Bacterial endotoxin induces fos immunoreactivity in primary afferent neurons of the vagus nerve.
NeuroImmunoModulation.
234-240.
1998
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Cytokines for psychologists: Implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition.
Psychological review.
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1998
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The role of the vagus nerve in cytokine-to-brain communication.
Annals of the New York Academy of Sciences.
289-300.
1998
- Evidence that brief stress may induce the acute phase response in rats. American Journal of Physiology. Regulatory Integrative and Comparative Physiology. R1998-R2004. 1997
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Evidence that brief stress may induce the acute phase response in rats..
American Journal of Physiology.
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The case of the missing brain: Arguments for a role of brain to spinal cord pathways in pain facilitation.
Behavioral and Brain Sciences.
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1997
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Subdiaphragmatic vagotomy does not prevent fever following intracerebroventricular prostaglandin E-2: further evidence for the importance of vagal afferents in immune-to-brain communication.
Brain Research.
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- Inescapable shock-induced potentiation of morphine analgesia in rats: Involvement of opioid, GABAergic, and serotonergic mechanisms in the dorsal raphe nucleus. Behavioral Neuroscience. 816-824. 1997
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Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat.
Pain.
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1997
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Reversal of spinal cord non-opiate analgesia by conditioned anti-analgesia in the rat.
Pain.
237-247.
1997
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Comparison of the effects of nucleus tractus solitarius and ventral medial medulla lesions on illness-induced and subcutaneous formalin-induced hyperalgesias.
Brain Research.
143-150.
1997
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TNF-alpha-induced corticosterone elevation but not serum protein or corticosteroid binding globulin reduction is vagally mediated.
Brain Research Bulletin.
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1997
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Vagal paraganglia bind biotinylated interleukin-1 receptor antagonist: A possible mechanism for immune-to-brain communication.
Brain Research Bulletin.
357-364.
1997
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Associative and non-associative mechanisms of morphine analgesic tolerance are neurochemically distinct in the rat spinal cord.
Psychopharmacology.
248-255.
1996
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Proinflammatory cytokines and specific immune function.
APS Journal.
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1996
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Peripheral beta-adrenoreceptors and stress-induced hypercholesterolemia in rats.
Physiology and Behavior.
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1996
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RU-486 blocks differentially suppressive effect of stress on in vivo anti-KLH immunoglobulin response.
American Journal of Physiology. Regulatory Integrative and Comparative Physiology.
R1344-R1352.
1996
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RU-486 blocks differentially suppressive effect of stress on in vivo anti-KLH immunoglobulin response..
American Journal of Physiology.
R1344-R1352.
1996
- Morphine-induced alterations in antibody levels: Receptor and immune mechanisms. Journal of Pharmacology and Experimental Therapeutics. 689-696. 1996
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Macrophage stimulation reduces the cholesterol levels of stressed and unstressed rats.
Life Sciences.
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1996
- The cytokine network: Role of immune system in mediating the effects of stressors. International Journal of Psychology. 1074-1074. 1996
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A LONG-TERM INCREASE IN BASAL LEVELS OF CORTICOSTERONE AND A DECREASE IN CORTICOSTEROID-BINDING GLOBULIN AFTER ACUTE STRESSOR EXPOSURE.
Endocrinology.
5336-5342.
1995
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Immune activation: The role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states.
Pain.
289-302.
1995
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THE ELEVATED PLUS-MAZE IS NOT SENSITIVE TO THE EFFECT OF STRESSOR CONTROLLABILITY IN RATS.
Pharmacology Biochemistry and Behavior.
565-570.
1995
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INTRACEREBROVENTRICULAR INTERLEUKIN-1 RECEPTOR ANTAGONIST BLOCKS THE ENHANCEMENT OF FEAR CONDITIONING AND INTERFERENCE WITH ESCAPE PRODUCED BY INESCAPABLE SHOCK.
Brain Research.
279-282.
1995
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MECHANISMS OF TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) HYPERALGESIA.
Brain Research.
244-250.
1995
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THE BENZODIAZEPINE RECEPTOR ANTAGONISTS FLUMAZENIL AND CGS8216 BLOCK THE ENHANCEMENT OF FEAR CONDITIONING AND INTERFERENCE WITH ESCAPE BEHAVIOR PRODUCED BY INESCAPABLE SHOCK.
Psychopharmacology.
250-258.
1995
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CYTOKINE-TO-BRAIN COMMUNICATION - A REVIEW AND ANALYSIS OF ALTERNATIVE MECHANISMS.
Life Sciences.
1011-1026.
1995
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THE DORSAL RAPHE NUCLEUS IS A SITE OF ACTION MEDIATING THE BEHAVIORAL-EFFECTS OF THE BENZODIAZEPINE RECEPTOR INVERSE AGONIST DMCM.
Behavioral Neuroscience.
759-766.
1995
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8-OH-DPAT MICROINJECTED IN THE REGION OF THE DORSAL RAPHE NUCLEUS BLOCKS AND REVERSES THE ENHANCEMENT OF FEAR CONDITIONING AND INTERFERENCE WITH ESCAPE PRODUCED BY EXPOSURE TO INESCAPABLE SHOCK.
Behavioral Neuroscience.
404-412.
1995
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STRESSED RATS FAIL TO EXPAND THE CD45RC(+)CD4(+) (TH1-LIKE) T-CELL SUBSET IN RESPONSE TO KLH - POSSIBLE INVOLVEMENT OF IFN-GAMMA.
Brain, Behavior, and Immunity.
101-112.
1995
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BLOCKADE OF CYTOKINE-INDUCED CONDITIONED TASTE-AVERSION BY SUBDIAPHRAGMATIC VAGOTOMY - FURTHER EVIDENCE FOR VAGAL MEDIATION OF IMMUNE-BRAIN COMMUNICATION.
Neuroscience Letters.
163-166.
1995
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BLOCKADE OF INTERLEUKIN-1 INDUCED HYPERTHERMIA BY SUBDIAPHRAGMATIC VAGOTOMY - EVIDENCE FOR VAGAL MEDIATION OF IMMUNE BRAIN COMMUNICATION.
Neuroscience Letters.
27-31.
1995
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INTERLEUKIN-1-BETA INDUCED CORTICOSTERONE ELEVATION AND HYPOTHALAMIC NE DEPLETION IS VAGALLY MEDIATED.
Brain Research Bulletin.
605-610.
1995
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STRESS-INDUCED REDUCTION IN THE RAT MIXED LYMPHOCYTE-REACTION IS DUE TO MACROPHAGES AND NOT TO CHANGES IN T-CELL PHENOTYPES.
Journal of Neuroimmunology.
45-52.
1995
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PSYCHONEUROIMMUNOLOGY - THE INTERFACE BETWEEN BEHAVIOR, BRAIN, AND IMMUNITY.
American Psychologist.
1004-1017.
1994
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ROUTE OF MORPHINE ADMINISTRATION MODULATES CONDITIONED ANALGESIC TOLERANCE AND HYPERALGESIA.
Pharmacology Biochemistry and Behavior.
1029-1035.
1994
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ILLNESS-INDUCED HYPERALGESIA IS MEDIATED BY A SPINAL NMDA NITRIC-OXIDE CASCADE.
Brain Research.
9-16.
1994
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ILLNESS-INDUCED HYPERALGESIA IS MEDIATED BY SPINAL NEUROPEPTIDES AND EXCITATORY AMINO-ACIDS.
Brain Research.
17-24.
1994
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A PERMISSIVE ROLE OF CORTICOSTERONE IN AN OPIOID FORM OF STRESS-INDUCED ANALGESIA - BLOCKADE OF OPIATE ANALGESIA IS NOT DUE TO STRESS-INDUCED HORMONE-RELEASE.
Brain Research.
19-29.
1994
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CHARACTERIZATION OF CYTOKINE-INDUCED HYPERALGESIA.
Brain Research.
15-26.
1994
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SUBCUTANEOUS FORMALIN PRODUCES CENTRIFUGAL HYPERALGESIA AT A NON-INJECTED SITE VIA THE NMDA NITRIC-OXIDE CASCADE.
Brain Research.
19-26.
1994
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A HORSERADISH-PEROXIDASE STUDY OF PARALLEL THALAMOCORTICAL PROJECTIONS RESPONSIBLE FOR THE GENERATION OF MIDLATENCY AUDITORY-EVOKED POTENTIALS.
Brain Research.
65-75.
1994
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NEUROCIRCUITRY OF ILLNESS-INDUCED HYPERALGESIA.
Brain Research.
283-299.
1994
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MORPHINE-INDUCED DECREASES IN IN-VIVO ANTIBODY-RESPONSES.
Brain, Behavior, and Immunity.
24-36.
1994
- ACUTE AND CONDITIONED HYPERALGESIC RESPONSES TO ILLNESS. Pain. 227-234. 1994
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THE NATURE OF CONDITIONED ANTI-ANALGESIA - SPINAL-CORD OPIATE AND ANTI-OPIATE NEUROCHEMISTRY.
Brain Research.
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1994
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MODULATION OF THE IN-VIVO ANTIBODY-RESPONSE BY A BENZODIAZEPINE INVERSE AGONIST (DMCM) ADMINISTERED CENTRALLY OR PERIPHERALLY.
Physiology and Behavior.
1149-1154.
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- ANESTHESIA-INDUCED MODULATION OF IN-VIVO ANTIBODY-LEVELS - A STUDY OF PENTOBARBITAL, CHLORAL HYDRATE, METHOXYFLURANE, HALOTHANE, AND KETAMINE XYLAZINE. Anesthesia and Analgesia. 769-774. 1993
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INTERLEUKIN-1 MEDIATES THE BEHAVIORAL HYPERALGESIA PRODUCED BY LITHIUM-CHLORIDE AND ENDOTOXIN.
Brain Research.
321-324.
1993
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OPIOID AND NONOPIOID INTERACTIONS IN 2 FORMS OF STRESS-INDUCED ANALGESIA.
Pharmacology Biochemistry and Behavior.
161-172.
1993
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THE AMYGDALA IS NECESSARY FOR THE EXPRESSION OF CONDITIONED BUT NOT UNCONDITIONED ANALGESIA.
Behavioral Neuroscience.
402-405.
1993
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THE ROLE OF THE AMYGDALA AND DORSAL RAPHE NUCLEUS IN MEDIATING THE BEHAVIORAL CONSEQUENCES OF INESCAPABLE SHOCK.
Behavioral Neuroscience.
377-388.
1993
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BLOCKADE OF THE HYPOTHALAMIC-PITUITARY-ADRENAL RESPONSE TO STRESS BY INTRAVENTRICULAR-INJECTION OF DEXAMETHASONE - A METHOD FOR STUDYING THE STRESS-INDUCED PERIPHERAL EFFECTS OF GLUCOCORTICOIDS.
Psychoneuroendocrinology.
251-263.
1993
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SPECIFIC CHANGES IN LYMPHOCYTE SUBPOPULATIONS - A POTENTIAL MECHANISM FOR STRESS-INDUCED IMMUNOMODULATION.
Journal of Neuroimmunology.
131-142.
1992
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CONDITIONED INHIBITION OF ANALGESIA.
Learning and Behavior.
339-349.
1992
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PARALLEL ACTIVATION OF MULTIPLE SPINAL OPIATE SYSTEMS APPEARS TO MEDIATE NONOPIATE STRESS-INDUCED ANALGESIAS.
Brain Research.
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1992
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SPATIAL SUMMATION IN HUMAN THERMAL PAIN PERCEPTION - COMPARISON WITHIN AND BETWEEN DERMATOMES.
Pain.
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1992
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DELTA OPIATE RECEPTORS MEDIATE TAIL-SHOCK INDUCED ANTINOCICEPTION AT SUPRASPINAL LEVELS.
Brain Research.
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1992
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KAPPA OPIATE RECEPTORS MEDIATE TAIL-SHOCK INDUCED ANTINOCICEPTION AT SPINAL LEVELS.
Brain Research.
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1992
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CHOLECYSTOKININ ANTIANALGESIA - SAFETY CUES ABOLISH MORPHINE ANALGESIA.
Science.
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1992
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A 9L gliosarcoma transplantation model for studying adoptive immunotherapy into the brains of conscious rats..
Cell Transplantation.
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1992
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CHARACTERIZATION OF INTRATHECAL VASOPRESSIN-INDUCED ANTINOCICEPTION, SCRATCHING BEHAVIOR, AND MOTOR SUPPRESSION.
Peptides.
17-25.
1992
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TOTAL PLASMA-CHOLESTEROL LEVELS OF RATS ARE INCREASED FOLLOWING ONLY 3 SESSIONS OF TAILSHOCK.
Life Sciences.
945-950.
1992
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CONDITIONED AND UNCONDITIONED STRESS-INDUCED ANALGESIA - STIMULUS PREEXPOSURE AND STIMULUS CHANGE.
Learning and Behavior.
295-304.
1991
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COMPARISON OF HUMAN PAIN SENSATION AND FLEXION WITHDRAWAL EVOKED BY NOXIOUS RADIANT-HEAT.
Pain.
259-268.
1991
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PHENYLEPHRINE-INDUCED ANTINOCICEPTION - INVESTIGATIONS OF POTENTIAL NEURAL AND ENDOCRINE BASES.
Brain Research.
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1990
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ELECTRICAL-STIMULATION OF THE RAT VENTRAL MIDBRAIN ELICITS ANTINOCICEPTION VIA THE DORSOLATERAL FUNICULUS.
Brain Research.
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1989
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ANTINOCICEPTION VS MOTOR EFFECTS OF INTRATHECAL VASOPRESSIN AS MEASURED BY 4 PAIN TESTS.
Brain Research.
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1988
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THE DORSAL RAPHE NUCLEUS - A RE-EVALUATION OF ITS PROPOSED ROLE IN OPIATE ANALGESIA SYSTEMS.
Brain Research.
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1988
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INHIBITION OF THE RESPONSES OF NEURONS IN THE RAT SPINAL-CORD TO NOXIOUS SKIN HEATING BY STIMULATION IN MIDBRAIN PERIAQUEDUCTAL GRAY OR LATERAL RETICULAR-FORMATION.
Brain Research.
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1986
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MULTIPLE ENDOGENOUS OPIATE AND NONOPIATE ANALGESIA SYSTEMS - EVIDENCE OF THEIR EXISTENCE AND CLINICAL IMPLICATIONS.
Annals of the New York Academy of Sciences.
273-299.
1986
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ROLE OF SPINAL-CORD NEUROPEPTIDES IN PAIN SENSITIVITY AND ANALGESIA - THYROTROPIN-RELEASING-HORMONE AND VASOPRESSIN.
Brain Research.
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1986
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Potentiation of Systemic Morphine Analgesia in Humans by Proglumide, a Cholecystokinin Antagonist.
Anesthesia and Analgesia.
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1985
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CHOLECYSTOKININ ANTAGONISTS SELECTIVELY POTENTIATE ANALGESIA INDUCED BY ENDOGENOUS OPIATES.
Brain Research.
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1985
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POTENTIATION OF MORPHINE ANALGESIA BY THE CHOLECYSTOKININ ANTAGONIST PROGLUMIDE.
Brain Research.
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1985
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SEXUAL RESPONSIVENESS AND ITS RELATIONSHIP TO VAGINAL STIMULATION-PRODUCED ANALGESIA IN THE RAT.
Brain Research.
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1985
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SPINAL PAIN SUPPRESSION MECHANISMS MAY DIFFER FOR PHASIC AND TONIC PAIN.
Brain Research.
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1985
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THE ENHANCEMENT OF OPIATE ANALGESIA AND THE POSSIBLE REVERSAL OF MORPHINE-TOLERANCE BY PROGLUMIDE.
Annals of the New York Academy of Sciences.
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1985
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THE POTENTIATION OF MORPHINE-INDUCED INHIBITION OF SPINAL TRANSMISSION BY PROGLUMIDE, A PUTATIVE CHOLECYSTOKININ ANTAGONIST.
Annals of the New York Academy of Sciences.
660-662.
1985
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A PSYCHOPHYSICAL ANALYSIS OF ACUPUNCTURE ANALGESIA.
Pain.
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1984
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BILATERAL LESIONS OF THE DORSOLATERAL FUNICULUS OF THE CAT SPINAL-CORD - EFFECTS ON BASAL NOCICEPTIVE REFLEXES AND NOCICEPTIVE SUPPRESSION PRODUCED BY CHOLINERGIC ACTIVATION OF THE PONTINE PARABRACHIAL REGION.
Brain Research.
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1984
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CATALEPTIC EFFECTS OF OPIATES FOLLOWING INTRATHECAL ADMINISTRATION.
Brain Research.
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1984
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COMPARISON OF THE EFFECTS OF VENTRAL MEDULLARY LESIONS ON SYSTEMIC AND MICROINJECTION MORPHINE ANALGESIA.
Brain Research.
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1984
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DIFFERENTIAL BEHAVIORAL-EFFECTS INDUCED BY INTRATHECAL MICROINJECTION OF OPIATES - COMPARISON OF CONVULSIVE AND CATALEPTIC EFFECTS PRODUCED BY MORPHINE, METHADONE, AND D-ALA2-METHIONINE-ENKEPHALINAMIDE.
Brain Research.
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1984
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DORSOLATERAL FUNICULUS AND INTRASPINAL PATHWAYS MEDIATE VAGINAL STIMULATION-INDUCED SUPPRESSION OF NOCICEPTIVE RESPONDING IN RATS.
Brain Research.
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1984
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EFFECT OF SPINAL-CORD LESIONS ON CONVULSIVE ACTIVITY INDUCED BY INTRATHECAL MORPHINE.
Brain Research.
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1984
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EVIDENCE FOR INVOLVEMENT OF CHOLINOCEPTIVE CELLS OF THE PARABRACHIAL REGION IN ENVIRONMENTALLY INDUCED NOCICEPTIVE SUPPRESSION IN THE CAT.
Brain Research.
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1984
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FEAR IS NOT CRITICAL TO CLASSICALLY-CONDITIONED ANALGESIA - THE EFFECTS OF PERIAQUEDUCTAL GRAY LESIONS AND ADMINISTRATION OF CHLORDIAZEPOXIDE.
Brain Research.
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1984
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MUSCARINIC CHOLINERGIC MEDIATION OF OPIATE AND NON-OPIATE ENVIRONMENTALLY INDUCED ANALGESIAS.
Brain Research.
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1984
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NON-OPIATE ANALGESIA INDUCED BY CARBACHOL MICROINJECTION INTO THE PONTINE PARABRACHIAL REGION OF THE CAT.
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NONSPECIFIC CONVULSIONS ARE INDUCED BY MORPHINE BUT NOT D-ALA2-METHIONINE-ENKEPHALINAMIDE AT CORTICAL SITES.
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1984
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OPIATE AND NON-OPIATE ANALGESIA INDUCED BY INESCAPABLE TAIL-SHOCK - EFFECTS OF DORSOLATERAL FUNICULUS LESIONS AND DECEREBRATION.
Brain Research.
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1984
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POTENTIATION OF OPIATE ANALGESIA AND APPARENT REVERSAL OF MORPHINE-TOLERANCE BY PROGLUMIDE.
Science.
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1984
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THE NEUROCHEMICAL BASIS OF FOOTSHOCK ANALGESIA - THE ROLE OF SPINAL-CORD SEROTONIN AND NOREPINEPHRINE.
Brain Research.
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1984
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EVIDENCE FOR THE NEUROPEPTIDE CHOLECYSTOKININ AS AN ANTAGONIST OF OPIATE ANALGESIA.
Science.
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1983
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OPIOID AND NON-OPIOID MECHANISMS OF FOOTSHOCK INDUCED ANALGESIA - ROLE OF THE SPINAL DORSOLATERAL FUNICULUS.
Brain Research.
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1983
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THE NEURAL BASIS OF FOOTSHOCK ANALGESIA - THE EFFECT OF PERIAQUEDUCTAL GRAY LESIONS AND DECEREBRATION.
Brain Research.
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1983
-
THE NEURAL BASIS OF FOOTSHOCK ANALGESIA - THE ROLE OF SPECIFIC VENTRAL MEDULLARY NUCLEI.
Brain Research.
305-315.
1983
-
CLASSICAL-CONDITIONING OF FRONT PAW AND HIND PAW FOOTSHOCK INDUCED ANALGESIA (FSIA) - NALOXONE REVERSIBILITY AND DESCENDING PATHWAYS.
Brain Research.
119-132.
1982
-
FAILURE OF SPINAL-CORD SEROTONIN DEPLETION TO ALTER ANALGESIA ELICITED FROM THE PERIAQUEDUCTAL GRAY.
Brain Research.
373-386.
1982
-
FOOTSHOCK INDUCED ANALGESIA IS DEPENDENT NEITHER ON PITUITARY NOR SYMPATHETIC ACTIVATION.
Brain Research.
81-96.
1982
-
INVOLVEMENT OF SPINAL OPIOID SYSTEMS IN FOOTSHOCK-INDUCED ANALGESIA - ANTAGONISM BY NALOXONE IS POSSIBLE ONLY BEFORE INDUCTION OF ANALGESIA.
Brain Research.
309-316.
1982
-
OPIATE VS NON-OPIATE FOOTSHOCK INDUCED ANALGESIA (FSIA) - DESCENDING AND INTRA-SPINAL COMPONENTS.
Brain Research.
97-106.
1982
-
OPIATE VS NON-OPIATE FOOTSHOCK-INDUCED ANALGESIA (FSIA) - THE BODY REGION SHOCKED IS A CRITICAL FACTOR.
Brain Research.
299-308.
1982
-
IDENTIFICATION AND SOMATOTOPIC ORGANIZATION OF NUCLEI PROJECTING VIA THE DORSOLATERAL FUNICULUS IN RATS - A RETROGRADE TRACING STUDY USING HRP SLOW-RELEASE GELS.
Brain Research.
237-255.
1981
-
SOMATOTOPIC ORGANIZATION OF THE NUCLEUS RAPHE MAGNUS AND SURROUNDING BRAIN-STEM STRUCTURES AS REVEALED BY HRP SLOW-RELEASE GELS.
Brain Research.
1-15.
1980
-
HRP PELLETS AND SLOW-RELEASE GELS - 2 NEW TECHNIQUES FOR GREATER LOCALIZATION AND SENSITIVITY.
Brain Research.
595-601.
1979
-
Caudal Granular Insular Cortex to Somatosensory Cortex I: A Critical Pathway for the Transition of Acute to Chronic Pain..
Journal of Neuroscience.
2026
Background
education and training
- Ph.D., Virginia Commonwealth University 1980
- B.S., University of California-Los Angeles 1976
awards and honors
International Activities
geographic focus
- Australia Country