Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling
Journal Article
Overview
publication date
- August 1, 2019
has subject area
- Animals
- Antigens, Surface - Lymphocyte Antigen 96
- Biochemical Phenomena - Signal Transduction
- Biochemical Phenomena - Structure-Activity Relationship
- Biological Factors - Interleukin-1beta
- Biological Factors - Interleukin-1beta
- Biological Factors - Tumor Necrosis Factor-alpha
- Biological Factors - Tumor Necrosis Factor-alpha
- Blood Proteins - Tumor Necrosis Factor-alpha
- Carrier Proteins - Lymphocyte Antigen 96
- Cell Differentiation
- Cell Line
- Cell Physiological Phenomena - Signal Transduction
- Cells - Astrocytes
- Cells - Microglia
- Cells, Cultured
- Heterocyclic Compounds, 4 or More Rings - Naltrexone
- Heterocyclic Compounds, Bridged-Ring - Naltrexone
- Male
- Mice
- Nervous System - Astrocytes
- Nervous System - Microglia
- Opiate Alkaloids - Naltrexone
- Peptides - Interleukin-1beta
- Peptides - Interleukin-1beta
- Peptides - Tumor Necrosis Factor-alpha
- Peptides - Tumor Necrosis Factor-alpha
- Pharmacological Phenomena - Structure-Activity Relationship
- Polycyclic Compounds - Naltrexone
- Protein Structure, Secondary
- Proteins - Interleukin-1beta
- Proteins - Interleukin-1beta
- Proteins - Tumor Necrosis Factor-alpha
- Proteins - Tumor Necrosis Factor-alpha
- Proteins - Tumor Necrosis Factor-alpha
- Rats
- Rats, Sprague-Dawley
- Stereoisomerism
- Toll-Like Receptor 4
has restriction
- green
Date in CU Experts
- June 18, 2019 2:17 AM
Full Author List
- Zhang X; Peng Y; Grace PM; Metcalf MD; Kwilasz AJ; Wang Y; Zhang T; Wu S; Selfridge BR; Portoghese PS
author count
- 14
citation count
- 15
published in
- The FASEB Journal Journal
Other Profiles
International Standard Serial Number (ISSN)
- 0892-6638
Electronic International Standard Serial Number (EISSN)
- 1530-6860
Digital Object Identifier (DOI)
Additional Document Info
start page
- 9577
end page
- 9587
volume
- 33
issue
- 8