Pharmacological Phenomena - Structure-Activity Relationship
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3'-AZIDOTHYMIDINE (ZIDOVUDINE) INHIBITS GLYCOSYLATION AND DRAMATICALLY ALTERS GLYCOSPHINGOLIPID SYNTHESIS IN WHOLE CELLS AT CLINICALLY RELEVANT CONCENTRATIONS Journal Article
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3'-terminal labelling of RNA with T4 RNA ligase. Journal Article
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A 29 residue region of the sarcomeric myosin rod is necessary for filament formation Journal Article
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A concise total synthesis of largazole, solution structure, and some preliminary structure activity relationships Journal Article
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A dual parameter FRET probe for measuring PKC and PKA activity in living cells Journal Article
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A general strategy to solve the phase problem in RNA crystallography Journal Article
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A structural analysis of the interaction between ncd tail and tubulin protofilaments Journal Article
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AN RNA MUTATION THAT INCREASES THE AFFINITY OF AN RNA PROTEIN-INTERACTION Journal Article
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Adenovirus type 5 and 7 capsid chimera: Fiber replacement alters receptor tropism without affecting primary immune neutralization epitopes Journal Article
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Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomyces pombe Journal Article
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Antiestrogen binding site and estrogen receptor mediate uptake and distribution of 4-hydroxytamoxifen-targeted doxorubicin-formaldehyde conjugate in breast cancer cells. Journal Article
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Antimicrobial peptide activity is anticorrelated with lipid a leaflet affinity Journal Article
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Architecture of the Synaptophysin/Synaptobrevin Complex: Structural Evidence for an Entropic Clustering Function at the Synapse Journal Article
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BASE SUBSTITUTION MUTANTS OF THE LAC OPERATOR - INVIVO AND INVITRO AFFINITIES FOR LAC REPRESSOR Journal Article
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Biotin tagging deletion analysis of domain limits involved in protein-macromolecular interactions. Mapping the tau binding domain of the DNA polymerase III alpha subunit. Journal Article
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COLOR CODED TRIARYLMETHYL PROTECTING GROUPS USEFUL FOR DEOXYPOLYNUCLEOTIDE SYNTHESIS Journal Article
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COMPARISON OF THE D-LACTATE STEREOSPECIFIC DEHYDROGENASE OF LIMULUS-POLYPHEMUS WITH ACTIVE-SITE REGIONS OF L-LACTATE DEHYDROGENASES Journal Article
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COMPARISON OF UBIQUINOL AND CYTOCHROME-C TERMINAL OXIDASES - AN ALTERNATIVE VIEW Journal Article
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CRYSTAL-STRUCTURE OF THE T4 REGA TRANSLATIONAL REGULATOR PROTEIN AT 1.9-ANGSTROM RESOLUTION Journal Article
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Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11 Journal Article
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Catalytic reaction pathway for the mitogen-activated protein kinase ERK2 Journal Article
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Cell biology - Lessons in rational drug design for protein kinases Journal Article
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Chemically Precise Glycoengineering Improves Human Insulin Journal Article
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Constrained saccharides: a review of structure, biology, and synthesis Journal Article
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Cortactin is a component of clathrin-coated pits and participates in receptor-mediated endocytosis Journal Article
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DNA CLEAVAGE CATALYZED BY THE RIBOZYME FROM TETRAHYMENA Journal Article
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Design, synthesis, and biological evaluation of doxorubicin - Formaldehyde conjugates targeted to breast cancer cells Journal Article
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Design, synthesis, and preliminary evaluation of doxazolidine carbamates as prodrugs activated by carboxylesterases Journal Article
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Discovery and initial structure-activity relationships of N-benzyl tricyclic indolines as antibacterials for methicillin-resistant Staphylococcus aureus Journal Article
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Dissecting the Innate Immune Recognition of Opioid Inactive Isomer (+)-Naltrexone Derived Toll-like Receptor 4 (TLR4) Antagonists Journal Article
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Does protein structure influence trypsin miscleavage? Journal Article
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EFFECT OF REPLACING URIDINE-33 IN YEAST TRANSFER RNAPHE ON THE REACTION WITH RIBOSOMES Journal Article
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ENRICHMENT FOR RNA MOLECULES THAT BIND A DIELS-ALDER TRANSITION-STATE ANALOG Journal Article
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Effect of Benzyl Alcohol on Recombinant Human Interleukin-1 Receptor Antagonist Structure and Hydrogen-Deuterium Exchange Journal Article
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Effect of replacing uridine 33 in yeast tRNAPhe on the reaction with ribosomes. Journal Article
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Effects of drying methods and additives on structure and function of actin: Mechanisms of dehydration-induced damage and its inhibition Journal Article
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Effects of nucleotide analogues on Euplotes aediculatus telomerase processivity: Evidence for product-assisted translocation Journal Article
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Effects of transmembrane and juxtamembrane domains on proliferative ability of TSLP receptor Journal Article
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Enzymatic replacement of the anticodon of yeast phenylalanine transfer ribonucleic acid. Journal Article
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Escherichia coli DNA polymerase II is stimulated by DNA polymerase III holoenzyme auxiliary subunits. Journal Article
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Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction. Journal Article
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FREE-ENERGY CONTRIBUTIONS OF G.U AND OTHER TERMINAL MISMATCHES TO HELIX STABILITY Journal Article
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FULL-LENGTH RAT ALPHA AND BETA CARDIAC MYOSIN HEAVY-CHAIN SEQUENCES - COMPARISONS SUGGEST A MOLECULAR-BASIS FOR FUNCTIONAL DIFFERENCES Journal Article
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FUNCTIONAL-ANALYSIS OF HUMAN CARDIAC GAP JUNCTION CHANNEL MUTANTS Journal Article
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From phage display to structure: an interplay of enthalpy and entropy in the binding of the LDHSLHS polypeptide to silica Journal Article
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Functional groups on the cleavage site pyrimidine nucleotide are required for stabilization of the hammerhead transition state Journal Article
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High-Throughput Screening AlphaScreen Assay for Identification of Small-Molecule Inhibitors of Ubiquitin E3 Ligase SCFSkp2-Cks1 Journal Article
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Human immunodeficiency virus reverse transcriptase. Expression in Escherichia coli, purification, and characterization of a functionally and structurally asymmetric dimeric polymerase. Journal Article
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IN-VITRO APPROACHES TO INVESTIGATION OF THE EARLY STEPS OF COLICIN-OMPF INTERACTION Journal Article
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INHIBITION OF DNA PRIMASE AND POLYMERASE-ALPHA BY ARABINOFURANOSYLNUCLEOSIDE TRIPHOSPHATES AND RELATED-COMPOUNDS Journal Article
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INHIBITION OF DYNAMIC PROTEIN PALMITOYLATION IN INTACT-CELLS WITH TUNICAMYCIN Book
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Identification of 4-aminopyrazolylpyrimidines as potent inhibitors of Trk kinases Journal Article
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Identification of the beta-binding domain of the alpha subunit of Escherichia coli polymerase III holoenzyme. Journal Article
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Independent folding and ligand specificity of the C2 calcium-dependent lipid binding domain of cytosolic phospholipase A2 Journal Article
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Inhibition of UDP-N-acetylglucosamine import into Golgi membranes by nucleoside monophosphates Journal Article
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Inhibitors of PARP: Number crunching and structure gazing Journal Article
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Inhibitory RNA ligand to reverse transcriptase from feline immunodeficiency virus Journal Article
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Interaction of R17 coat protein with synthetic variants of its ribonucleic acid binding site. Journal Article
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Interactions between single-stranded DNA binding protein and oligonucleotide analogs with different backbone chemistries Journal Article
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Internal equilibrium of the hammerhead ribozyme is altered by the length of certain covalent cross-links Journal Article
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Ire1-mediated decay in mammalian cells relies on mRNA sequence, structure, and translational status Journal Article
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KINETIC CONTROL OF CA(II) SIGNALING - TUNING THE ION DISSOCIATION RATES OF EF-HAND CA(II) BINDING-SITES Journal Article
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Kinetic chain lengths in highly cross-linked networks formed by the photoinitiated polymerization of divinyl monomers: A gel permeation chromatography investigation Journal Article
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Localizing the adhesive and signaling functions of plakoglobin Journal Article
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Long Noncoding RNAs: Molecular Modalities to Organismal Functions Journal Article
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MECHANISM OF DNA-REPLICATION FIDELITY FOR 3 MUTANTS OF DNA-POLYMERASE-I - KLENOW FRAGMENT KF(EXO+), KF(POLA5), AND KF(EXO-) Journal Article
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MOLECULAR EVOLUTION, INTRACELLULAR ORGANIZATION, AND THE QUINARY STRUCTURE OF PROTEINS Journal Article
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MUTANTS OF THE BACTERIOPHAGE-MS2 COAT PROTEIN THAT ALTER ITS COOPERATIVE BINDING TO RNA Journal Article
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Mechanism of Competitive Inhibition and Destabilization of Acidothermus cellulolyticus Endoglucanase 1 by Ionic Liquids Journal Article
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Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate. Journal Article
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Membrane-Permeant Phosphoinositide Derivatives as Modulators of Growth Factor Signaling and Neurite Outgrowth Journal Article
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Microscopic evidence for a minus-end-directed power stroke in the kinesin motor ncd Journal Article
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Mutations at the same amino acid in myosin that cause either skeletal or cardiac myopathy have distinct molecular phenotypes Journal Article
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NATURE OF THE RIBOSOMAL MESSENGER-RNA TRACK - ANALYSIS OF RIBOSOME-BINDING SITES CONTAINING DIFFERENT SEQUENCES AND SECONDARY STRUCTURES Journal Article
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New inhibitors of colony spreading in Bacillus subtilis and Bacillus anthracis Journal Article
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Non-charged thiamine analogs as inhibitors of enzyme transketolase Journal Article
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Nucleoside and nucleotide inactivation of R17 coat protein: evidence for a transient covalent RNA-protein bond. Journal Article
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OXYTRICHA TELOMERIC NUCLEOPROTEIN COMPLEXES RECONSTITUTED WITH SYNTHETIC DNA Journal Article
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Optimization of storage stability of lyophilized actin using combinations of disaccharides and dextran Journal Article
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Overview of the SAMPL5 host-guest challenge: Are we doing better? Journal Article
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PHOSPHORODITHIOATE DNA AS A POTENTIAL THERAPEUTIC DRUG Journal Article
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PHOTOLYSIS INTERMEDIATES OF THE ARTIFICIAL VISUAL PIGMENT CIS-5,6-DIHYDRO-ISORHODOPSIN Journal Article
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PROPERTIES OF AN IN-VITRO SELECTED PB2+ CLEAVAGE MOTIF Journal Article
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PROTEIN PROTEIN INTERACTIONS WITH THE ACIDIC COOH TERMINUS OF THE SINGLE-STRANDED DNA-BINDING PROTEIN OF THE BACTERIOPHAGE-T4 Journal Article
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Pentachlorophenol Hydroxylase, a Poorly Functioning Enzyme Required for Degradation of Pentachlorophenol by Sphingobium chlorophenolicum Journal Article
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Phenotypic analysis of separation-of-function alleles of MEI-41, Drosophila ATM/ATR Journal Article
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Phosphorylation-dependent changes in structure and dynamics in ERK2 detected by SDSL and EPR Journal Article
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Phylogenetic-comparative analysis of the eukaryal ribonuclease P RNA Journal Article
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Polarity of 2-D and 3-D maps of tubulin sheets and motor-decorated sheets Journal Article
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Polymerizable Vancomycin Derivatives for Bactericidal Biomaterial Surface Modification: Structure-Function Evaluation Journal Article
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Post-SELEX combinatorial optimization of aptamers Journal Article
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Preferential binding of the histone (H3-H4)2 tetramer by NAP1 is mediated by the amino-terminal histone tails Journal Article
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Prothymosin Alpha: A Novel Contributor to Estradiol Receptor Alpha-Mediated CD8+ T-Cell Pathogenic Responses and Recognition of Type 1 Collagen in Rheumatic Heart Valve Disease Journal Article
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QUANTITATIVE-ANALYSIS OF THE RELATIONSHIP BETWEEN NUCLEOTIDE-SEQUENCE AND FUNCTIONAL-ACTIVITY Journal Article
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Quinazolin-2-ylamino-quinazolin-4-ols as novel non-nucleoside inhibitors of bacterial DNA polymerase III Journal Article
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RECOGNITION OF TERTIARY STRUCTURE IN TRANSFER-RNAS BY RH(PHEN)2PHI3+, A NEW REAGENT FOR RNA STRUCTURE-FUNCTION MAPPING Journal Article
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REQUIREMENT OF HEPARAN-SULFATE FOR BFGF-MEDIATED FIBROBLAST GROWTH AND MYOBLAST DIFFERENTIATION Journal Article
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RNA as the catalyst for drug screening - Reporter ribozymes that allow monitoring of protein-nucleic acid and protein-protein interactions facilitate rapid identification of inhibitors for use in drug discovery. Journal Article
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RNA biophysics has come of age. Journal Article
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RNA-BINDING SITE OF R17 COAT PROTEIN Journal Article
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ROLE OF DIVALENT METAL-IONS IN THE HAMMERHEAD RNA CLEAVAGE REACTION Journal Article
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ROLE OF THE SYK AUTOPHOSPHORYLATION SITE AND SH2 DOMAINS IN B-CELL ANTIGEN RECEPTOR SIGNALING Journal Article
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Redox Regulation of SH2-Domain-Containing Protein Tyrosine Phosphatases by Two Backdoor Cysteines Journal Article
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Removal of Y-37 from tRNA phe yeast alters oligomer binding to two loops. Journal Article
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Riboswitches: Emerging themes in RNA structure and function Journal Article
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Role of the constant uridine in binding of yeast tRNAPhe anticodon arm to 30S ribosomes. Journal Article
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SELECTIVE ENRICHMENT OF RNA SPECIES FOR TIGHT-BINDING TO ESCHERICHIA-COLI RHO-FACTOR Journal Article
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SEQUENCE REQUIREMENTS FOR SELF-SPLICING OF THE TETRAHYMENA-THERMOPHILA PRE-RIBOSOMAL RNA Journal Article
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SEQUENCE REQUIREMENTS OF THE HAMMERHEAD RNA SELF-CLEAVAGE REACTION Journal Article
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SOLUTION STRUCTURE OF BOVINE NEUTROPHIL BETA-DEFENSIN-12 - THE PEPTIDE FOLD OF THE BETA-DEFENSINS IS IDENTICAL TO THAT OF THE CLASSICAL DEFENSINS Journal Article
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SPECIFIC SUBSTITUTION INTO THE ANTICODON LOOP OF YEAST TYROSINE TRANSFER-RNA Journal Article
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STABILITY OF XGCGCP, GCGCYP, AND XGCGCYP HELIXES - AN EMPIRICAL ESTIMATE OF THE ENERGETICS OF HYDROGEN-BONDS IN NUCLEIC-ACIDS Journal Article
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STRUCTURAL FEATURES THAT GIVE RISE TO THE UNUSUAL STABILITY OF RNA HAIRPINS CONTAINING GNRA LOOPS Journal Article
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STUDIES ON GENE CONTROL REGIONS .3. BINDING OF SYNTHETIC AND MODIFIED SYNTHETIC LAC OPERATOR DNAS TO LACTOSE REPRESSOR Journal Article
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STUDIES ON THE HAMMERHEAD RNA SELF-CLEAVING DOMAIN Journal Article
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Size classes of products synthesized processively by DNA polymerase III and DNA polymerase III holoenzyme of Escherichia coli. Journal Article
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Skip residues modulate the structural properties of the myosin rod and guide thick filament assembly Journal Article
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Solid-Phase Synthesis, Thermal Denaturation Studies, Nuclease Resistance, and Cellular Uptake of (Oligodeoxyribonucleoside)methylborane Phosphine-DNA Chimeras Journal Article
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Specific volume and adiabatic compressibility measurements of native and aggregated recombinant human interleukin-1 receptor antagonist: Density differences enable pressure-modulated refolding Journal Article
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Specificity of hammerhead ribozyme cleavage Journal Article
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Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling Journal Article
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Steric interference modification of the hammerhead ribozyme Journal Article
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Structural Insights into Apoptotic DNA Degradation by CED-3 Protease Suppressor-6 (CPS-6) from Caenorhabditis elegans Journal Article
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Structural Refinement of Glucagon for Therapeutic Use Journal Article
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Structural and functional innovations in the real-time evolution of new (βα)8 barrel enzymes Journal Article
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Structural insights into the interactions of Polycomb Repressive Complex 2 with chromatin Journal Article
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Structural perspective on the activation of RNase P RNA by protein Journal Article
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Structural requirements for basolateral sorting of the human transferrin receptor in the biosynthetic and endocytic pathways of Madin-Darby canine kidney cells Journal Article
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Structural variation induced by different nucleotides at the cleavage site of the hammerhead ribozyme Journal Article
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Structure and function analysis of the C-elegans aminophospholipid translocase TAT-1 Journal Article
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Structure and function of eukaryotic ribonuclease P RNA Journal Article
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Structure of Mediator of RhoA-Dependent Invasion (MRDI) Explains Its Dual Function as a Metabolic Enzyme and a Mediator of Cell Invasion Journal Article
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Structure-Activity Relationship Studies of the Tricyclic Indoline Resistance-Modifying Agent Journal Article
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Structure-Activity Relationship of Flavin Analogues That Target the Flavin Mononucleotide Riboswitch Journal Article
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Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists Journal Article
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Structure-Function Analysis of the C-terminal Domain of CNM67, a Core Component of the Saccharomyces cerevisiae Spindle Pole Body Journal Article
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Structure-Property Relationships for Tailoring Phenoxazines as Reducing Photoredox Catalysts Journal Article
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Structure-activity relationship studies of [1,2,5]oxadiazolo[3,4-b] pyrazine-containing polymyxin-selective resistance-modifying agents Journal Article
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Structure/function of oxygen-regulated isoforms in cytochrome c oxidase. Journal Article
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Structures of Kinesin Motor Proteins Journal Article
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Structures of kinesin and kinesin-microtubule interactions Journal Article
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Studies of targeting and intracellular trafficking of an anti-androgen doxorubicin-formaldehyde conjugate in PC-3 prostate cancer cells bearing androgen receptor-GFP chimera Journal Article
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Switching human telomerase on and off with hPOT1 protein in vitro Journal Article
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Synthesis and Biological Activities of Azalamellarins Journal Article
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Synthesis and biological studies with dithioate DNA. Journal Article
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Synthesis of modified nucleoside 3',5'-bisphosphates and their incorporation into oligoribonucleotides with T4 RNA ligase. Journal Article
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Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors Journal Article
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TELOMERIC PROTEIN-DNA POINT CONTACTS IDENTIFIED BY PHOTO-CROSS-LINKING USING 5-BROMODEOXYURIDINE Journal Article
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TERTIARY INTERACTIONS WITH THE INTERNAL GUIDE SEQUENCE MEDIATE DOCKING OF THE P1 HELIX INTO THE CATALYTIC CORE OF THE TETRAHYMENA RIBOZYME Journal Article
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THE EFFECT OF BASE MISMATCHES IN THE SUBSTRATE RECOGNITION HELICES OF HAMMERHEAD RIBOZYMES ON BINDING AND CATALYSIS Journal Article
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THE GENERALITY OF SELF-SPLICING RNA - RELATIONSHIP TO NUCLEAR MESSENGER-RNA SPLICING Journal Article
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THE ISOFORMS OF YEAST CYTOCHROME-C-OXIDASE SUBUNIT-V ALTER THE INVIVO KINETIC-PROPERTIES OF THE HOLOENZYME Journal Article
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THE ROLE OF 2'-HYDROXYL GROUPS IN AN RNA-PROTEIN INTERACTION Journal Article
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THIOPHOSPHATE INTERFERENCE EXPERIMENTS LOCATE PHOSPHATES IMPORTANT FOR THE HAMMERHEAD RNA SELF-CLEAVAGE REACTION Journal Article
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TRANSLATION INITIATION COMPLEX-FORMATION WITH 30-S RIBOSOMAL PARTICLES MUTATED AT CONSERVED POSITIONS IN THE 3'-MINOR DOMAIN OF 16-S RNA Journal Article
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TRANSMEMBRANE SIGNALING BY THE ASPARTATE RECEPTOR - ENGINEERED DISULFIDES REVEAL STATIC REGIONS OF THE SUBUNIT INTERFACE Journal Article
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Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines Journal Article
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Tetracyclic indolines as a novel class of β-lactam-selective resistance-modifying agent for MRSA Journal Article
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The 3.2 Å Resolution Structure of a Receptor:CheA:CheW Signaling Complex Defines Overlapping Binding Sites and Key Residue Interactions within Bacterial Chemosensory Arrays Journal Article
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The Escherichia coli DEAD protein DbpA recognizes a small RNA hairpin in 23S rRNA Journal Article
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The Cac2 subunit is essential for productive histone binding and nucleosome assembly in CAF-1 Journal Article
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The Discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors Journal Article
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The Histone Chaperone FACT: Structural Insights and Mechanisms for Nucleosome Reorganization Journal Article
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The beta subunit of the DNA polymerase III holoenzyme becomes inaccessible to antibody after formation of an initiation complex with primed DNA. Journal Article
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The carboxy-terminal domain of the DExD/H protein YxiN is sufficient to confer specificity for 23 S rRNA Journal Article
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The hammerhead ribozyme Conference Proceeding
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The mammalian myosin heavy chain gene family Journal Article
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The nongenotoxic carcinogens naphthalene and para-dichlorobenzene suppress apoptosis in Caenorhabditis elegans Journal Article
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The role of hydrogel structure and dynamic loading on chondrocyte gene expression and matrix formation Journal Article
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The structure-function dilemma of the hammerhead ribozyme. Journal Article
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Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases Journal Article
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Tryptoline-based benzothiazoles re-sensitize MRSA to β-lactam antibiotics Journal Article
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Two Classes of Myosin Inhibitors, Para-nitroblebbistatin and Mavacamten, Stabilize β-Cardiac Myosin in Different Structural and Functional States Journal Article
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Understanding histone acetyltransferase Rtt109 structure and function: how many chaperones does it take? Journal Article
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Uridine-33 in yeast tRNA not essential for amber suppression. Journal Article
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Use of F-19 NMR to probe protein structure and conformational changes Journal Article
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WATER-SOLUBLE 3RD GENERATION ANTITUMOR PLATINUM COMPLEXES, [2,2-BIS(AMINOMETHYL)-1,3-PROPANEDIOL-N,N']-[1,1-CYCLOBUTANEDICARBOXYLATO(2-)-O,O']PLATINUM(II) AND [1,1-CYCLOBUTANEDICARBOXYLATO(2-)-O,O'][TETRAHYDRO-4H-PYRAN-4,4-DIMETHANAMINE-N,N']PLATINUM(II)3 Journal Article
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Yin Yang 1 represses alpha-myosin heavy chain gene expression in pathologic cardiac hypertrophy Journal Article
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