Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases
Journal Article
Overview
publication date
- July 1, 2017
has subject area
- Biochemical Phenomena - Structure-Activity Relationship
- Cell Line - HeLa Cells
- DNA-Binding Proteins - Trans-Activators
- Elements - Zinc
- Enzyme Inhibitors
- Enzymes - Proteasome Endopeptidase Complex
- Epithelial Cells - HeLa Cells
- Humans
- Metalloproteases
- Metals - Zinc
- Molecular Mechanisms of Pharmacological Action - Chelating Agents
- Multiprotein Complexes - Proteasome Endopeptidase Complex
- Peptide Hydrolases - Proteasome Endopeptidase Complex
- Pharmacological Phenomena - Dose-Response Relationship, Drug
- Pharmacological Phenomena - Structure-Activity Relationship
- Pyrrolidinones
- Specialty Uses of Chemicals - Chelating Agents
- Toxicological Phenomena - Dose-Response Relationship, Drug
- Transcription Factors - Trans-Activators
- Transition Elements - Zinc
- Tumor Cells, Cultured - HeLa Cells
- Viral Regulatory and Accessory Proteins - Trans-Activators
has restriction
- green
Date in CU Experts
- May 2, 2017 5:08 AM
Full Author List
- Lauinger L; Li J; Shostak A; Cemel IA; Ha N; Zhang Y; Merkl PE; Obermeyer S; Stankovic-Valentin N; Schafmeier T
author count
- 19
citation count
- 85
published in
- Nature Chemical Biology Journal
Other Profiles
International Standard Serial Number (ISSN)
- 1552-4450
Electronic International Standard Serial Number (EISSN)
- 1552-4469
Digital Object Identifier (DOI)
Additional Document Info
start page
- 709
end page
- +
volume
- 13
issue
- 7