ACTIVATION OF ADULT RAT CNS ENDOTHELIAL CELLS BY OPIOID-INDUCED TOLL-LIKE RECEPTOR 4 (TLR4) SIGNALING INDUCES PROINFLAMMATORY, BIOCHEMICAL, MORPHOLOGICAL, AND BEHAVIORAL SEQUELAE
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Overview
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Animals
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Autacoids - Dinoprostone
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Biological Factors - Tumor Necrosis Factor-alpha
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Biological Factors - Tumor Necrosis Factor-alpha
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Blood Proteins - Tumor Necrosis Factor-alpha
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Cells - Neuroglia
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Central Nervous System
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Central Nervous System Agents - Narcotics
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Central Nervous System Agents - Narcotics
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Cyclooxygenase 2
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DNA-Binding Proteins - NF-kappa B
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Electrophysiological Phenomena - Neuroimmunomodulation
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Endothelial Cells
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Fatty Acids, Unsaturated - Dinoprostone
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Heterocyclic Compounds, 4 or More Rings - Morphine
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Heterocyclic Compounds, 4 or More Rings - Morphine Derivatives
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Heterocyclic Compounds, Bridged-Ring - Morphine
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Heterocyclic Compounds, Bridged-Ring - Morphine Derivatives
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Immune System Phenomena - Neuroimmunomodulation
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Male
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Multiprotein Complexes - NF-kappa B
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Nervous System - Neuroglia
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Nervous System Diseases - Hyperalgesia
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Nervous System Physiological Phenomena - Neuroimmunomodulation
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Nuclear Proteins - NF-kappa B
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Opiate Alkaloids - Morphine
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Opiate Alkaloids - Morphine Derivatives
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Peptides - Cyclic AMP-Dependent Protein Kinases
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Peptides - Tumor Necrosis Factor-alpha
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Peptides - Tumor Necrosis Factor-alpha
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Physiological Effects of Drugs - Narcotics
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Polycyclic Compounds - Morphine
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Polycyclic Compounds - Morphine Derivatives
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Protein-Serine-Threonine Kinases - Cyclic AMP-Dependent Protein Kinases
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Proteins - Cyclic AMP-Dependent Protein Kinases
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Proteins - Tumor Necrosis Factor-alpha
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Proteins - Tumor Necrosis Factor-alpha
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Proteins - Tumor Necrosis Factor-alpha
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RNA, Messenger
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Rats, Sprague-Dawley
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Receptors, G-Protein-Coupled - Receptors, Opioid, mu
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Receptors, Neurotransmitter - Receptors, Opioid, mu
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Receptors, Peptide - Receptors, Opioid, mu
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Sensory System Agents - Narcotics
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Signs and Symptoms - Hyperalgesia
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Toll-Like Receptor 4
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Transcription Factors - NF-kappa B
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Vasodilation
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Date in CU Experts
Full Author List
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Grace PM; Ramos KM; Rodgers KM; Wang X; Hutchinson MR; Lewis MT; Morgan KN; Kroll JL; Taylor FR; Strand KA
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