Signs and Symptoms - Hyperalgesia
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subject area of
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A minocycline derivative reduces nerve injury-induced allodynia, LPS-induced prostaglandin E2 microglial production and signaling via toll-like receptors 2 and 4 Journal Article
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A new model of sciatic inflammatory neuritis (SIN): induction of unilateral and bilateral mechanical allodynia following acute unilateral peri-sciatic immune activation in rats Journal Article
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A novel method for modeling facial allodynia associated with migraine in awake and freely moving rats Journal Article
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A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine Journal Article
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A single peri-sciatic nerve administration of the adenosine 2A receptor agonist ATL313 produces long-lasting anti-allodynia and anti-inflammatory effects in male rats Journal Article
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ACTIVATION OF ADULT RAT CNS ENDOTHELIAL CELLS BY OPIOID-INDUCED TOLL-LIKE RECEPTOR 4 (TLR4) SIGNALING INDUCES PROINFLAMMATORY, BIOCHEMICAL, MORPHOLOGICAL, AND BEHAVIORAL SEQUELAE Journal Article
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ACUTE AND CONDITIONED HYPERALGESIC RESPONSES TO ILLNESS Journal Article
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Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents Journal Article
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Acute increases in intramuscular inflammatory cytokines are necessary for the development of mechanical hypersensitivity in a mouse model of musculoskeletal sensitization Journal Article
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Aging and miR-155 in mice influence survival and neuropathic pain after spinal cord injury Journal Article
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Altered C-tactile processing in human dynamic tactile allodynia Journal Article
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An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine Journal Article
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Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy Journal Article
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CHARACTERIZATION OF CYTOKINE-INDUCED HYPERALGESIA Journal Article
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Caudal Granular Insular Cortex Is Sufficient and Necessary for the Long-Term Maintenance of Allodynic Behavior in the Rat Attributable to Mononeuropathy Journal Article
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Comparison of the effects of nucleus tractus solitarius and ventral medial medulla lesions on illness-induced and subcutaneous formalin-induced hyperalgesias Journal Article
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Constriction of the buccal branch of the facial nerve produces unilateral craniofacial allodynia Journal Article
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Counter-Regulation of Opioid Analgesia by Glial-Derived Bioactive Sphingolipids Journal Article
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Diffuse traumatic brain injury induces prolonged immune dysregulation and potentiates hyperalgesia following a peripheral immune challenge Journal Article
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EVIDENCE THAT INTRATHECAL MORPHINE-3-GLUCURONIDE MAY CAUSE PAIN ENHANCEMENT VIA TOLL-LIKE RECEPTOR 4/MD-2 AND INTERLEUKIN-1β Journal Article
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Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat Journal Article
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Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats Journal Article
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Evidence that opioids may have toll-like receptor 4 and MD-2 effects Journal Article
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Exploring acute-to-chronic neuropathic pain in rats after contusion spinal cord injury Journal Article
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Glial proinflammatory cytokines mediate exaggerated pain states: Implications for clinical pain Journal Article
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Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain Journal Article
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HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia Journal Article
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Harnessing pain heterogeneity and RNA transcriptome to identify blood-based pain biomarkers: a novel correlational study design and bioinformatics approach in a graded chronic constriction injury model Journal Article
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ILLNESS-INDUCED HYPERALGESIA IS MEDIATED BY A SPINAL NMDA NITRIC-OXIDE CASCADE Journal Article
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ILLNESS-INDUCED HYPERALGESIA IS MEDIATED BY SPINAL NEUROPEPTIDES AND EXCITATORY AMINO-ACIDS Journal Article
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INTERLEUKIN-1 MEDIATES THE BEHAVIORAL HYPERALGESIA PRODUCED BY LITHIUM-CHLORIDE AND ENDOTOXIN Journal Article
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Immune activation: The role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states Journal Article
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Implications of immune-to-brain communication for sickness and pain Journal Article
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Indwelling Supradural Catheters for Induction of Facial Allodynia: Surgical Procedures, Application of Inflammatory Stimuli, and Behavioral Testing Journal Article
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Intraneural dexamethasone applied simultaneously to rat sciatic nerve constriction delays the development of hyperalgesia and allodynia Journal Article
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Intrathecal HIV-1 envelope glycoprotein gp120 induces enhanced pain states mediated by spinal cord proinflammatory cytokines Journal Article
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Intrathecal injection of adenosine 2A receptor agonists reversed neuropathic allodynia through protein kinase (PK)A/PKC signaling Journal Article
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Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats Journal Article
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Intrathecal non-viral interleukin-10 gene therapy ameliorates neuropathic pain as measured by both classical static allodynia and a novel supra-spinally mediated pain assay, the Two-Arm Rodent Somatosensory (TARS) task Journal Article
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MECHANISMS OF TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) HYPERALGESIA Journal Article
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MicroRNA-124 and microRNA-146a both attenuate persistent neuropathic pain induced by morphine in male rats Journal Article
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Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury Journal Article
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Musculoskeletal Sensitization and Sleep: Chronic Muscle Pain Fragments Sleep of Mice without Altering Its Duration Journal Article
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NEUROCIRCUITRY OF ILLNESS-INDUCED HYPERALGESIA Journal Article
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Opioid Activation of Toll-Like Receptor 4 Contributes to Drug Reinforcement Journal Article
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Opioid-Induced Central Immune Signaling: Implications for Opioid Analgesia Journal Article
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POSSIBLE INVOLVEMENT OF TOLL-LIKE RECEPTOR 4/MYELOID DIFFERENTIATION FACTOR-2 ACTIVITY OF OPIOID INACTIVE ISOMERS CAUSES SPINAL PROINFLAMMATION AND RELATED BEHAVIORAL CONSEQUENCES Journal Article
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Pain Intensity and Duration Can Be Enhanced by Prior Challenge: Initial Evidence Suggestive of a Role of Microglial Priming Journal Article
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Peri-sciatic proinflammatory cytokines, reactive oxygen species, and complement induce mirror-image neuropathic pain in rats Journal Article
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Pioglitazone rapidly reduces neuropathic pain through astrocyte and nongenomic PPAR-γ mechanisms Journal Article
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Post-conditioning experience with acute or chronic inflammatory pain reduces contextual fear conditioning in the rat Journal Article
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Prior exposure to glucocorticoids potentiates lipopolysaccharide induced mechanical allodynia and spinal neuroinflammation Journal Article
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Prior exposure to repeated morphine potentiates mechanical allodynia induced by peripheral inflammation and neuropathy Journal Article
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Prior voluntary wheel running attenuates neuropathic pain Journal Article
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Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia Journal Article
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Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats Journal Article
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ROUTE OF MORPHINE ADMINISTRATION MODULATES CONDITIONED ANALGESIC TOLERANCE AND HYPERALGESIA Journal Article
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Reduced sleep, stress responsivity, and female sex contribute to persistent inflammation-induced mechanical hypersensitivity in rats Journal Article
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Repeated Morphine Prolongs Postoperative Pain in Male Rats Journal Article
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Rifampin inhibits Toll-like receptor 4 signaling by targeting myeloid differentiation protein 2 and attenuates neuropathic pain Journal Article
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SUBCUTANEOUS FORMALIN PRODUCES CENTRIFUGAL HYPERALGESIA AT A NON-INJECTED SITE VIA THE NMDA NITRIC-OXIDE CASCADE Journal Article
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Select steroid hormone glucuronide metabolites can cause toll-like receptor 4 activation and enhanced pain Journal Article
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Sleep Fragmentation Exacerbates Mechanical Hypersensitivity and Alters Subsequent Sleep-Wake Behavior in a Mouse Model of Musculoskeletal Sensitization Journal Article
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Snake venom components enhance pain upon subcutaneous injection:: an initial examination of spinal cord mediators Journal Article
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Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide Journal Article
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Spinal cord glia and interleukin-1 do not appear to mediate persistent allodynia induced by intramuscular acidic saline in rats Journal Article
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Spinal gap junctions: Potential involvement in pain facilitation Journal Article
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Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats Journal Article
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Suppression of Voluntary Wheel Running in Rats Is Dependent on the Site of Inflammation: Evidence for Voluntary Running as a Measure of Hind Paw-Evoked Pain Journal Article
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Suppression of active phase voluntary wheel running in male rats by unilateral chronic constriction injury: Enduring therapeutic effects of a brief treatment of morphine combined with TLR4 or P2X7 antagonists Journal Article
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Supradural inflammatory soup in awake and freely moving rats induces facial allodynia that is blocked by putative immune modulators Journal Article
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Sustained reversal of central neuropathic pain induced by a single intrathecal injection of adenosine A2A receptor agonists Journal Article
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Systemic Administration of Propentofylline, Ibudilast, and (+)-Naltrexone Each Reverses Mechanical Allodynia in a Novel Rat Model of Central Neuropathic Pain Journal Article
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The pain of being sick: Implications of immune-to-brain communication for understanding pain Journal Article
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Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120 Journal Article
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Unilateral T13 and L1 Dorsal Root Avulsion: Methods for a Novel Model of Central Neuropathic Pain Journal Article