Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice
Journal Article
Overview
publication date
- March 1, 2012
has subject area
- Animals
- Animals, Inbred Strains - Mice, Inbred BALB C
- Biochemical Phenomena - Phosphorylation
- Biochemical Phenomena - Signal Transduction
- Carrier Proteins - Myeloid Differentiation Factor 88
- Cell Physiological Phenomena - Signal Transduction
- Cells - Motor Neurons
- Central Nervous System Agents - Hypnotics and Sedatives
- Cerebral Cortex - Hippocampus
- DNA-Binding Proteins - I-kappa B Proteins
- DNA-Binding Proteins - NF-KappaB Inhibitor alpha
- DNA-Binding Proteins - NF-kappa B
- Ethanol
- Heterocyclic Compounds, 4 or More Rings - Naloxone
- Heterocyclic Compounds, Bridged-Ring - Naloxone
- Limbic System - Hippocampus
- Male
- Metabolism - Phosphorylation
- Mice
- Mice - Mice, Inbred BALB C
- Multiprotein Complexes - NF-kappa B
- Mutation
- Nervous System - Motor Neurons
- Nuclear Proteins - NF-kappa B
- Opiate Alkaloids - Naloxone
- Organic Chemistry Phenomena - Phosphorylation
- Peptides - I-kappa B Proteins
- Peptides - MAP Kinase Kinase 4
- Peptides - Mitogen-Activated Protein Kinase Kinases
- Peptides - Myeloid Differentiation Factor 88
- Peptides - NF-KappaB Inhibitor alpha
- Peptides - p38 Mitogen-Activated Protein Kinases
- Physiological Effects of Drugs - Hypnotics and Sedatives
- Polycyclic Compounds - Naloxone
- Protein-Serine-Threonine Kinases - MAP Kinase Kinase 4
- Protein-Serine-Threonine Kinases - Mitogen-Activated Protein Kinase Kinases
- Protein-Serine-Threonine Kinases - p38 Mitogen-Activated Protein Kinases
- Protein-Tyrosine Kinases - MAP Kinase Kinase 4
- Protein-Tyrosine Kinases - Mitogen-Activated Protein Kinase Kinases
- Proteins - I-kappa B Proteins
- Proteins - MAP Kinase Kinase 4
- Proteins - Mitogen-Activated Protein Kinase Kinases
- Proteins - Myeloid Differentiation Factor 88
- Proteins - NF-KappaB Inhibitor alpha
- Proteins - p38 Mitogen-Activated Protein Kinases
- Toll-Like Receptor 4
- Transcription Factors - I-kappa B Proteins
- Transcription Factors - NF-KappaB Inhibitor alpha
- Transcription Factors - NF-kappa B
has restriction
- bronze
Date in CU Experts
- October 4, 2013 2:45 AM
Full Author List
- Wu Y; Lousberg EL; Moldenhauer LM; Hayball JD; Coller JK; Rice KC; Watkins LR; Somogyi AA; Hutchinson MR
author count
- 9
citation count
- 57
published in
- British Journal of Pharmacology Journal
Other Profiles
International Standard Serial Number (ISSN)
- 0007-1188
Digital Object Identifier (DOI)
Additional Document Info
start page
- 1319
end page
- 1329
volume
- 165
issue
- 5