research overview
- Regulation of epigenetic silencing by RNA and replication of chromosome telomeres.
- Contact Info
Cech, Tom
Positions
- Faculty Director, Biofrontiers Institute
- Distinguished Professor, Molecular, Cellular & Developmental Biology (MCDB)
- Distinguished Professor, Biochemistry
Research Areas
Research
keywords
- Interdisciplinary research and education
Publications
selected publications
-
chapter
- Molecular Science of Fluctuations Toward Biological Functions Foreword. V-VI. 2016
- THE RNA WORLD THIRD EDITION The Nature of Modern RNA Suggests a Prebiotic RNA World Preface. Cold Spring Harbor Monograph Series. IX-X. 2006
- The RNP World. Cold Spring Harbor Monograph Series. 309-326. 2006
- Overturning the Dogma: Catalytic RNA 2001
- Building a Catalytic Active Site Using Only RNA 1999
- Structure and Mechanism of the Large Catalytic RNAs: Group I and Group II Introns and Ribonuclease P 1999
- RNA: Getting the Message 1995
- The Origin of Life and the Value of Life 1995
- Multiple Enzymatic Activities of an Intervening Sequence RNA from Tetrahymena 1987
- Viroids Contain Sequences Characteristic of Group I Introns 1987
- Ribosomal RNA Gene Expression in Tetrahymena: Transcription and RNA Splicing 1986
- Confrontational Dynamics Involved in RNA Self-Splicing 1986
- Mechanism of Self-Splicing of the Ribosomal RNA Precursor of Tetrahymena 1986
- Self-Splicing of the Ribosomal RNA Precursor of Tetrahymena 1983
-
conference proceeding
- Human CST assembles into a decameric supercomplex upon binding to single-stranded telomeric DNA. Biophysical Journal. 1-2. 2022
- TERT Promoter Mutations and Cancer. The FASEB Journal. 2016
- TERT Promoter Mutations and Cancer. The FASEB Journal. 2016
- RNA as a Flexible Scaffold for Proteins: Yeast Telomerase and Beyond. Cold Spring Harbor Laboratory: Symposia on Quantitative Biology. 217-224. 2006
- MECHANISM AND STRUCTURE OF A CATALYTIC RNA MOLECULE. 91-110. 1993
-
journal article
-
PRC2-RNA interactions: Viewpoint from Tom Cech, Chen Davidovich, and Richard Jenner.
Molecular Cell.
3593-3595.
2024
-
Small molecule telomerase inhibitors are also potent inhibitors of telomeric C-strand synthesis..
RNA.
1213-1226.
2024
-
Transcription factors ERĪ± and Sox2 have differing multiphasic DNA- and RNA-binding mechanisms..
RNA.
1089-1105.
2024
-
Telomerase misbehaves after a breakup Suppressing telomerase action at broken DNA preserves genome integrity.
Science.
702-703.
2024
-
Telomerase RNA structural heterogeneity in living human cells detected by DMS-MaPseq
2023
-
Structural basis for inactivation of PRC2 by G-quadruplex RNA.
Science.
1331-1337.
2023
-
Evaluation of the RNA-dependence of PRC2 binding to chromatin in human pluripotent stem cells.
2023
-
Multiple RNA- and DNA- binding proteins exhibit direct transfer of polynucleotides with implications for target- site search.
Proceedings of the National Academy of Sciences of USA.
2023
-
PRC2 direct transfer from G-quadruplex RNA to dsDNA has implications for RNA-binding chromatin modifiers.
Proceedings of the National Academy of Sciences of USA.
2023
-
Supplementary Figures 1-8 from Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers
2023
-
Supplementary Figures 1-8 from Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers
2023
-
Supplementary Methods and Table S1 from Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers
2023
-
Supplementary Methods and Table S1 from Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers
2023
-
DNMT1 inhibition by pUG-fold quadruplex RNA.
RNA.
346-360.
2023
-
DNMT1 inhibition by pUG-fold quadruplex RNA.
RNA.
346-360.
2023
-
DNMT1 inhibition by pUG-fold quadruplex RNA.
RNA.
346-360.
2023
-
DNMT1 inhibition by pUG-fold quadruplex RNA..
RNA.
346-360.
2023
-
The complexity of transferring genetic information..
Molecular Cell.
2023
-
DNMT1 inhibition by pUG-fold quadruplex RNA
2022
-
Reconstitution of a telomeric replicon organized by CST.
Nature.
819-+.
2022
-
Polycomb-mediated genome architecture enables long-range spreading of H3K27 methylation.
Proceedings of the National Academy of Sciences of USA.
2022
-
RNA in biological condensates INTRODUCTION.
RNA.
1-2.
2022
-
CST does not evict elongating telomerase but prevents initiation by ssDNA binding.
Nucleic Acids Research.
11653-11665.
2021
-
Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention (vol 12, 3308, 2021).
Nature Communications.
2021
-
TRIM28 is a transcriptional activator of the mutant TERT in human bladder cancer.
Proceedings of the National Academy of Sciences of USA.
2021
-
Targeted mutagenesis in human iPSCs using CRISPR genome-editing tools.
Methods.
44-58.
2021
-
Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention.
Nature Communications.
2021
-
Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization.
Nature Reviews Molecular Cell Biology.
283-298.
2021
-
Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization (Feb, 10.1038/s41580-021-00328-y, 2021).
Nature Reviews Molecular Cell Biology.
299-299.
2021
-
Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells.
Molecular Cell.
488-+.
2021
-
Allele-specific proximal promoter hypomethylation of the telomerase reverse transcriptase gene (TERT) associates withTERTexpression in multiple cancers.
Molecular Oncology.
2358-2374.
2020
-
RNA is essential for PRC2 chromatin occupancy and function in human pluripotent stem cells.
Nature Genetics.
931-+.
2020
-
Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA transcripts is driven by intron retention: implications for RNA-directed therapies
2020
-
Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers.
Molecular Cancer Research.
1050-1062.
2020
-
The structure of human CST reveals a decameric assembly bound to telomeric DNA.
Science.
1081-+.
2020
-
Bending and looping of long DNA by Polycomb repressive complex 2 revealed by AFM imaging in liquid.
Nucleic Acids Research.
2969-2981.
2020
-
The cryo-EM structure of human CST reveals a two-megadalton decameric assembly bound to telomeric DNA
2019
-
Regulation of histone methylation by automethylation of PRC2.
Genes and Development.
1416-1427.
2019
-
Single-cell imaging reveals unexpected heterogeneity of telomerase reverse transcriptase expression across human cancer cell lines.
Proceedings of the National Academy of Sciences of USA.
18488-18497.
2019
-
C9orf72 and triplet repeat disorder RNAs: G-quadruplex formation, binding to PRC2 and implications for disease mechanisms.
RNA.
935-947.
2019
-
Fission yeast telosomes: non-canonical histone-containing chromatin structures dependent on shelterin and RNA.
Nucleic Acids Research.
8865-8875.
2018
-
A Lifelong Passion for All Things Ribonucleic.
Cell.
14-17.
2018
-
In Crystallo Selection to Establish New RNA Crystal Contacts.
Structure.
1275-+.
2018
-
Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits.
Genes and Development.
794-805.
2018
-
Dynamics of human telomerase recruitment depend on template-telomere base pairing.
Molecular Biology of the Cell.
869-880.
2018
-
Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes.
Cell Reports.
3700-3707.
2017
-
Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA.
Nature Structural and Molecular Biology.
1028-+.
2017
-
Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2.
eLife.
2017
-
Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity.
Nature Communications.
2017
-
How do lncRNAs regulate transcription?.
Science Advances.
2017
-
Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines.
Molecular Cell.
1056-+.
2017
-
Targeted CRISPR disruption reveals a role for RNase MRP RNA in human preribosomal RNA processing.
Genes and Development.
59-71.
2017
-
Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres.
Cell.
1188-+.
2016
-
RNA Duplex Map in Living Cells Reveals Higher-Order Transcriptome Structure.
Cell.
1267-1279.
2016
-
Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects.
Nature Structural and Molecular Biology.
286-292.
2016
-
The recruitment of chromatin modifiers by long noncoding RNAs: lessons from PRC2.
RNA.
2007-2022.
2015
-
A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression.
Genome Biology.
2015
-
Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers.
Genes and Development.
2219-2224.
2015
-
Protein-RNA interaction restricts telomerase from running through the stop sign.
Nature Structural and Molecular Biology.
835-836.
2015
-
Nucleic acid-binding specificity of human FUS protein.
Nucleic Acids Research.
7535-7543.
2015
-
Human telomerase: biogenesis, trafficking, recruitment, and activation.
Genes and Development.
1095-1105.
2015
-
RNA World research-still evolving.
RNA.
474-475.
2015
-
Contributions of the TEL-patch Amino Acid Cluster on TPP1 to Telomeric DNA Synthesis by Human Telomerase.
Journal of Molecular Biology.
1291-1303.
2015
- Placental Expression of the lncRNA NEAT1 Increases in Preeclampsia. Reproductive Sciences. 201A-201A. 2015
- Placental Expression of the lncRNA NEAT1, and Not MENb or TncRNA, Increases With Gestation. Reproductive Sciences. 189A-189A. 2015
-
TERT promoter mutations and telomerase reactivation in urothelial cancer.
Science.
1006-1010.
2015
-
Toward a Consensus on the Binding Specificity and Promiscuity of PRC2 for RNA.
Molecular Cell.
552-558.
2015
-
Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance.
Journal of Cell Science.
331-341.
2015
-
Biochemical Properties and Biological Functions of FET Proteins.
Annual Review of Biochemistry.
355-379.
2015
-
Academia and industry: Companies on campus..
Nature.
297-298.
2014
-
Companies on campus.
Nature.
297-298.
2014
-
Identification of human TERT elements necessary for telomerase recruitment to telomeres.
eLife.
2014
-
FUS is sequestered in nuclear aggregates in ALS patient fibroblasts.
Molecular Biology of the Cell.
2571-2578.
2014
-
Structure and Function of Steroid Receptor RNA Activator Protein, the Proposed Partner of SRA Noncoding RNA.
Journal of Molecular Biology.
1766-1785.
2014
-
The Noncoding RNA Revolution-Trashing Old Rules to Forge New Ones.
Cell.
77-94.
2014
-
Telomerase in Bladder Cancer: Back to a Better Future?.
European Urology.
370-371.
2014
-
Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT.
Nucleic Acids Research.
8565-8577.
2014
-
NAR Breakthrough Article A dimeric state for PRC2.
Nucleic Acids Research.
9236-9248.
2014
-
Inhibition of Telomerase Recruitment and Cancer Cell Death.
Journal of Biological Chemistry.
33171-33180.
2013
-
Promiscuous RNA binding by Polycomb repressive complex 2.
Nature Structural and Molecular Biology.
1250-U273.
2013
-
RNA Seeds Higher-Order Assembly of FUS Protein.
Cell Reports.
918-925.
2013
-
Many disease-associated variants of hTERT retain high telomerase enzymatic activity.
Nucleic Acids Research.
8969-8978.
2013
-
3 ' terminal diversity of MRP RNA and other human noncoding RNAs revealed by deep sequencing.
BMC Molecular Biology.
2013
-
RNA recognition by the DNA end-binding Ku heterodimer.
RNA.
841-851.
2013
-
Finding the end: recruitment of telomerase to telomeres.
Nature Reviews Molecular Cell Biology.
71-+.
2013
-
How a Chemist Looks at RNA.
Angewandte Chemie International Edition.
75-78.
2013
-
FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2.
Genes and Development.
2690-2695.
2012
-
The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.
Nature.
285-+.
2012
-
SnapShot: Telomeres and Telomerase.
Cell.
2012
-
The RNA Worlds in Context.
Cold Spring Harbor perspectives in biology.
2012
-
RNase P branches out from RNP to protein: organelle-triggered diversification?.
Genes and Development.
1005-1009.
2012
-
Mutually Exclusive Binding of Telomerase RNA and DNA by Ku Alters Telomerase Recruitment Model.
Cell.
922-932.
2012
- Mutually exclusive binding of telomerase RNA and DNA by Ku alters telomerase recruitment model.. Cell. 922-32-922-32. 2012
-
DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe.
Nucleic Acids Research.
235-244.
2012
- DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe.. 235-44-235-44. 2012
-
The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis.
Nature Structural and Molecular Biology.
1371-U84.
2011
-
Multiple POT1-TPP1 Proteins Coat and Compact Long Telomeric Single-Stranded DNA.
Journal of Molecular Biology.
10-17.
2011
-
Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells.
Nature.
399-+.
2011
-
Ku can contribute to telomere lengthening in yeast at multiple positions in the telomerase RNP.
RNA.
298-311.
2011
-
Tetrahymena Telomerase Protein p65 Induces Conformational Changes throughout Telomerase RNA (TER) and Rescues Telomerase Reverse Transcriptase and TER Assembly Mutants.
Molecular and Cellular Biology.
4965-4976.
2010
-
Engineering cis-telomerase RNAs that add telomeric repeats to themselves.
Proceedings of the National Academy of Sciences of USA.
4914-4918.
2010
-
Functional interaction between telomere protein TPP1 and telomerase.
Genes and Development.
613-622.
2010
-
POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation.
The EMBO Journal.
924-933.
2010
-
How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA.
Proceedings of the National Academy of Sciences of USA.
651-656.
2010
-
Crawling Out of the RNA World.
Cell.
599-602.
2009
-
A natural ribozyme with 3 ',5 ' RNA ligase activity.
Nature Chemical Biology.
97-99.
2009
-
Inhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13p.
Nucleic Acids Research.
354-367.
2009
-
Evolution of Biological Catalysis: Ribozyme to RNP Enzyme.
Cold Spring Harbor Laboratory: Symposia on Quantitative Biology.
11-16.
2009
-
Toward predicting self-splicing and protein-facilitated splicing of group I introns.
RNA.
2013-2029.
2008
-
Mutation in TERT separates processivity from anchor-site function.
Nature Structural and Molecular Biology.
871-872.
2008
-
Multiple yeast genes, including Paf1 complex genes, affect telomere length via telomerase RNA abundance.
Molecular and Cellular Biology.
4152-4161.
2008
-
Triple-helix structure in telomerase RNA contributes to catalysis.
Nature Structural and Molecular Biology.
634-640.
2008
-
On the occasion of the 25(th) anniversary of the discovery of catalytic RNA.
Biological Chemistry: official scientific journal of the GBM.
661-662.
2007
-
Local RNA structural changes induced by crystallization are revealed by SHAPE.
RNA.
536-548.
2007
-
The POT1-TPP1 telomere complex is a telomerase processivity factor.
Nature.
506-510.
2007
-
Low abundance of telomerase in yeast: Implications for telomerase haploinsufficiency.
RNA.
1721-1737.
2006
- Crystal structure of an essential telomerase-specific domain of TERT. The FASEB Journal. A984-A984. 2006
-
Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme.
RNA.
387-395.
2006
-
Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase.
Nature Structural and Molecular Biology.
218-225.
2006
-
Atomic level architecture of group I introns revealed.
Trends in Biochemical Sciences.
41-51.
2006
-
RNA as a flexible scaffold for proteins: Yeast telomerase and beyond.
Cold Spring Harbor Laboratory: Symposia on Quantitative Biology.
217-224.
2006
-
A miniature yeast telomerase RNA functions in vivo and reconstitutes activity in vitro.
Nature Structural and Molecular Biology.
1072-1077.
2005
-
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates.
Journal of Biological Chemistry.
32069-32080.
2005
-
Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro.
Proceedings of the National Academy of Sciences of USA.
10864-10869.
2005
-
Soluble domains of telomerase reverse transcriptase identified by high-throughput screening.
Protein Science.
2051-2058.
2005
-
Switching human telomerase on and off with hPOT1 protein in vitro.
Journal of Biological Chemistry.
20449-20456.
2005
-
Expression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase.
Journal of Biological Chemistry.
5249-5257.
2005
- Fostering innovation and discovery in biomedical research.. 1390-3-1390-3. 2005
-
Global expression changes resulting from loss of telomeric DNA in fission yeast.
Genome Biology.
2005
-
Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection.
Nature Structural and Molecular Biology.
1223-1229.
2004
-
Structure of the Tetrahymena ribozyme:: Base triple sandwich and metal ion at the active site.
Molecular Cell.
351-362.
2004
-
Self-splicing and enzymatic activity of an intervening sequence RNA from Tetrahymena.
Bioscience Reports: molecular and cellular biology of the cell surface.
362-385.
2004
-
Yeast telomerase RNA: A flexible scaffold for protein subunits.
Proceedings of the National Academy of Sciences of USA.
10024-10029.
2004
-
The Euplotes telomerase subunit p43 stimulates enzymatic activity and processivity in vitro.
RNA.
1108-1118.
2004
-
RNA finds a simpler way.
Nature.
263-264.
2004
-
Beginning to understand the end of the chromosome.
Cell.
273-279.
2004
- Nurturing interdisciplinary research.. 1166-9-1166-9. 2004
-
Tetrahymena telomerase is active as a monomer.
Molecular Biology of the Cell.
4794-4804.
2003
-
DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA.
Nature.
198-203.
2003
-
DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA..
Nature.
198-203.
2003
-
A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity.
RNA.
1323-1332.
2003
-
Sequence-specific and 3 '-end selective single-strand DNA binding by the Oxytricha nova telomere end binding protein alpha subunit.
Biochemistry.
9269-9277.
2003
-
Human POT1 facilitates telomere elongation by telomerase.
Current Biology.
942-946.
2003
-
The Euplotes La motif protein p43 has properties of a telomerase-specific subunit.
Biochemistry.
5736-5747.
2003
-
Yeast telomerase is specialized for C/A-rich RNA templates.
Nucleic Acids Research.
1646-1655.
2003
-
Rebalancing teaching and research.
Science.
165-165.
2003
-
N-terminal domain of yeast telomerase reverse transcriptase: Recruitment of Est3p to the telomerase complex.
Molecular Biology of the Cell.
1-13.
2003
- Sharing publication-related data and materials: responsibilities of authorship in the life sciences.. 19-24-19-24. 2003
-
Cooperative binding of single-stranded telomeric DNA by the Pot1 protein of Schizosaccharomyces pombe.
Biochemistry.
14560-14568.
2002
-
A bulged stem tethers Est1p to telomerase RNA in budding yeast.
Genes and Development.
2800-2812.
2002
-
Evolution of Tetrahymena ribozyme mutants with increased structural stability.
Nature Structural and Molecular Biology.
855-861.
2002
-
Human Pot1 (Protection of telomeres) protein: Cytolocalization, gene structure, and alternative splicing.
Molecular and Cellular Biology.
8079-8087.
2002
-
Ribozymes, the first 20 years.
Biochemical Society Transactions.
1162-1166.
2002
-
The chemical repertoire of natural ribozymes.
Nature.
222-228.
2002
-
In vivo selection of better self-splicing introns in Escherichia coli:: The role of the P1 extension helix of the Tetrahymena intron.
RNA.
647-658.
2002
-
Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction..
Molecular and Cellular Biology.
2366-2374.
2002
-
Effects of nucleotide analogues on Euplotes aediculatus telomerase processivity: Evidence for product-assisted translocation.
Biochemistry.
151-161.
2002
-
A stem-loop of Tetrahymena telomerase RNA distant from the template potentiates RNA folding and telomerase activity.
Biochemistry.
7005-7016.
2001
-
Pot1, the putative telomere end-binding protein in fission yeast and humans.
Science.
1171-1175.
2001
-
Engineering disulfide cross-links in RNA using thiol-disulfide interchange chemistry..
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.].
Unit-5.1.
2001
-
Structural basis of the enhanced stability of a mutant ribozyme domain and a detailed view of RNA-solvent interactions.
Structure.
221-231.
2001
- Two RNA machines: Ribozyme and telomerase. The FASEB Journal. A57-A57. 2001
-
An early transition state for folding of the P4-P6 RNA domain.
RNA.
161-166.
2001
- Engineering disulfide cross-links in RNA using thiol-disulfide interchange chemistry.. Unit 5.1-Unit 5.1. 2001
- Science and business. Conflicts of interestāmoving beyond disclosure.. Science. 989-989. 2001
-
Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting.
The EMBO Journal.
6230-6239.
2000
-
Multiple folding pathways for the P4-P6 RNA domain.
Biochemistry.
12465-12475.
2000
-
Protection of telomeres by the Ku protein in fission yeast.
Molecular Biology of the Cell.
3265-3275.
2000
-
A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity.
Journal of Biological Chemistry.
24199-24207.
2000
-
Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase.
Molecular Cell.
493-499.
2000
-
Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomyces pombe.
Proceedings of the National Academy of Sciences of USA.
6367-6372.
2000
-
Life at the end of the chromosome: Telomeres and telomerase.
Angewandte Chemie International Edition.
34-43.
2000
- Structural biology. The ribosome is a ribozyme.. Science. 878-9-878-9. 2000
-
Quantifying the energetic interplay of RNA tertiary and secondary structure interactions.
RNA.
1665-1674.
1999
- Science at liberal arts colleges: A better education?. Daedalus. 195-216. 1999
-
Self-splicing of the Tetrahymena intron from mRNA in mammalian cells.
The EMBO Journal.
6491-6500.
1999
-
Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants.
Genes and Development.
2863-2874.
1999
-
RNA tertiary folding monitored by fluorescence of covalently attached pyrene.
Biochemistry.
14224-14237.
1999
- Hot papers - Telomerase - Telomerase catalytic subunit homologs from fission yeast and human by T.M. Nakamura, G.B. Morin, K.B. Chapman, S.L. Weinrich, W.H. Andrews, J. Lingner, C.B. Harley, T.E. Cech - Comments. Scientist (Philadelphia, Pa.). 14-14. 1999
-
Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle.
Nature.
177-180.
1999
-
In vitro selection of RNAs with increased tertiary structure stability.
RNA.
1119-1129.
1999
-
Energetics and cooperativity of tertiary hydrogen bonds in RNA structure.
Biochemistry.
8691-8702.
1999
-
Telomerase and the maintenance of chromosome ends.
Current Opinion in Cell Biology.
318-324.
1999
-
In vitro selection of the Naegleria GIR1 ribozyme identifies three base changes that dramatically improve activity.
RNA.
1481-1492.
1998
-
Two modes of survival of fission yeast without telomerase.
Science.
493-496.
1998
-
A preorganized active site in the crystal structure of the Tetrahymena ribozyme.
Science.
259-264.
1998
-
A quantitative study of the flexibility contributed to RNA structures by nicks and single-stranded gaps.
RNA.
1179-1185.
1998
-
Peptidyl-transferase ribozymes: trans reactions, structural characterization and ribosomal RNA-like features.
Chemistry and Biology.
539-553.
1998
-
Thermodynamic stability of the P4-P6 domain RNA tertiary structure measured by temperature gradient gel electrophoresis.
Biochemistry.
11162-11170.
1998
-
Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax.
Proceedings of the National Academy of Sciences of USA.
8479-8484.
1998
-
Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha.
Genes and Development.
1504-1514.
1998
-
Binding of the protein kinase PKR to RNAs with secondary structure defects: Role of the tandem A-G mismatch and noncontiguous helixes.
Biochemistry.
6303-6316.
1998
-
Euplotes telomerase: Evidence for limited base-pairing during primer elongation and dGTP as an effector of translocation.
Biochemistry.
5162-5172.
1998
-
Telomerase and chromosome end maintenance.
Current Opinion in Genetics and Development.
226-232.
1998
-
Reversing time: Origin of telomerase.
Cell.
587-590.
1998
- Are telomeres correlative or causative in cellular senescence? General discussion. Ciba Foundation symposium. 145-147. 1998
- Human ageing and telomeres - Discussion. Ciba Foundation symposium. 139-144. 1998
- Mouse models for the study of telomerase - Discussion. Ciba Foundation symposium. 170-176. 1998
- Repair and processing events at DNA ends - Discussion. Ciba Foundation symposium. 205-208. 1998
- Telomerase and the chromosome end replication problem. Ciba Foundation symposium. 20-28. 1998
- Telomerase assays in the diagnosis and prognosis of cancer - Discussion. Ciba Foundation symposium. 155-159. 1998
- Telomeres and telomerase in other organisms. Ciba Foundation symposium. 223-226. 1998
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MITOCHONDRIAL TELOMERES - SURPRISING DIVERSITY OF REPEATED TELOMERIC DNA-SEQUENCES AMONG 6 SPECIES OF TETRAHYMENA.
Cell.
367-374.
1988
-
PHYLOGENETIC-RELATIONSHIPS AND ALTERED GENOME STRUCTURES AMONG TETRAHYMENA MITOCHONDRIAL DNAS.
Nucleic Acids Research.
327-346.
1988
- BIOLOGIC CATALYSIS BY RNA. Harvey lectures. 123-144. 1988
-
3-DIMENSIONAL MODEL OF THE ACTIVE-SITE OF THE SELF-SPLICING RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA.
Proceedings of the National Academy of Sciences of USA.
8788-8792.
1987
-
SELF-SPLICING RNA AND AN RNA ENZYME IN TETRAHYMENA.
The Journal of protozoology.
416-417.
1987
-
TELOMERIC DNA PROTEIN INTERACTIONS OF OXYTRICHA MACRONUCLEAR DNA.
Genes and Development.
783-793.
1987
-
STRUCTURAL CONVENTIONS FOR GROUP-I INTRONS.
Nucleic Acids Research.
7217-7221.
1987
-
SELECTION OF CIRCULARIZATION SITES IN A GROUP-1 IVS RNA REQUIRES MULTIPLE ALIGNMENTS OF AN INTERNAL TEMPLATE-LIKE SEQUENCE.
Cell.
951-961.
1987
-
5' EXON REQUIREMENT FOR SELF-SPLICING OF THE TETRAHYMENA-THERMOPHILA PRE-RIBOSOMAL RNA AND IDENTIFICATION OF A CRYPTIC 5' SPLICE SITE IN THE 3' EXON.
Journal of Molecular Biology.
49-60.
1987
-
THE CHEMISTRY OF SELF-SPLICING RNA AND RNA ENZYMES.
Science.
1532-1539.
1987
-
GUANOSINE BINDING REQUIRED FOR CYCLIZATION OF THE SELF-SPLICING INTERVENING SEQUENCE RIBONUCLEIC-ACID FROM TETRAHYMENA-THERMOPHILA.
Biochemistry.
3330-3340.
1987
- RNA AS AN ENZYME. The FASEB Journal. 2020-2020. 1987
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STRUCTURES INVOLVED IN TETRAHYMENA RIBOSOMAL-RNA SELF-SPLICING AND RNA ENZYME-ACTIVITY.
Cold Spring Harbor Laboratory: Symposia on Quantitative Biology.
147-157.
1987
-
THE TETRAHYMENA RIBOZYME ACTS LIKE AN RNA RESTRICTION ENDONUCLEASE.
Nature.
429-433.
1986
-
RNA AS AN ENZYME.
Scientific American.
64-&.
1986
-
ONE BINDING-SITE DETERMINES SEQUENCE SPECIFICITY OF TETRAHYMENA PRE-RIBOSOMAL-RNA SELF-SPLICING, TRANSSPLICING, AND RNA ENZYME-ACTIVITY.
Cell.
207-216.
1986
-
THE TELOMERES OF THE LINEAR MITOCHONDRIAL-DNA OF TETRAHYMENA THERMOPHILA CONSIST OF 53-BP TANDEM REPEATS.
Cell.
873-883.
1986
-
RIBOZYME INHIBITORS - DEOXYGUANOSINE AND DIDEOXYGUANOSINE ARE COMPETITIVE INHIBITORS OF SELF-SPLICING OF THE TETRAHYMENA RIBOSOMAL RIBONUCLEIC-ACID PRECURSOR.
Biochemistry.
4473-4477.
1986
-
THE TETRAHYMENA INTERVENING SEQUENCE RIBONUCLEIC-ACID ENZYME IS A PHOSPHOTRANSFERASE AND AN ACID-PHOSPHATASE.
Biochemistry.
4478-4482.
1986
-
MECHANISM OF RECOGNITION OF THE 5' SPLICE SITE IN SELF-SPLICING GROUP-I INTRONS.
Nature.
86-89.
1986
-
A MODEL FOR THE RNA-CATALYZED REPLICATION OF RNA.
Proceedings of the National Academy of Sciences of USA.
4360-4363.
1986
-
NEW REACTIONS OF THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA AND THE MECHANISM OF SELF-SPLICING.
Journal of Molecular Biology.
143-165.
1986
-
ROLE OF CONSERVED SEQUENCE ELEMENT-9L AND ELEMENT-2 IN SELF-SPLICING OF THE TETRAHYMENA RIBOSOMAL-RNA PRECURSOR.
Cell.
167-176.
1986
-
THE GENERALITY OF SELF-SPLICING RNA - RELATIONSHIP TO NUCLEAR MESSENGER-RNA SPLICING.
Cell.
207-210.
1986
-
THE INTERVENING SEQUENCE RNA OF TETRAHYMENA IS AN ENZYME.
Science.
470-475.
1986
-
BIOLOGICAL CATALYSIS BY RNA.
Annual Review of Biochemistry.
599-629.
1986
- THE INTERVENING SEQUENCE RNA OF TETRAHYMENA IS AN ENZYME. Journal of Cellular Biochemistry. 88-88. 1986
-
SITES OF CIRCULARIZATION OF THE TETRAHYMENA RIBOSOMAL-RNA IVS ARE DETERMINED BY SEQUENCE AND INFLUENCED BY POSITION AND SECONDARY STRUCTURE.
Nucleic Acids Research.
8389-8408.
1985
-
COUPLING OF TETRAHYMENA RIBOSOMAL-RNA SPLICING TO BETA-GALACTOSIDASE EXPRESSION IN ESCHERICHIA-COLI.
Science.
719-722.
1985
-
INTERMOLECULAR EXON LIGATION OF THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA - OLIGONUCLEOTIDES CAN FUNCTION AS 5' EXONS.
Cell.
431-437.
1985
-
OLIGOMERIZATION OF INTERVENING SEQUENCE RNA MOLECULES IN THE ABSENCE OF PROTEINS.
Science.
1060-1064.
1985
-
REACTIONS OF THE INTERVENING SEQUENCE OF THE TETRAHYMENA RIBOSOMAL RIBONUCLEIC-ACID PRECURSOR - PH-DEPENDENCE OF CYCLIZATION AND SITE-SPECIFIC HYDROLYSIS.
Biochemistry.
6211-6218.
1985
-
REVERSIBILITY OF CYCLIZATION OF THE TETRAHYMENA RIBOSOMAL-RNA INTERVENING SEQUENCE - IMPLICATION FOR THE MECHANISM OF SPLICE SITE CHOICE.
Cell.
639-648.
1985
-
SECONDARY STRUCTURE OF THE CIRCULAR FORM OF THE TETRAHYMENA RIBOSOMAL-RNA INTERVENING SEQUENCE - A TECHNIQUE FOR RNA STRUCTURE-ANALYSIS USING CHEMICAL PROBES AND REVERSE-TRANSCRIPTASE.
Proceedings of the National Academy of Sciences of USA.
648-652.
1985
-
SELF-CATALYZED CYCLIZATION OF THE INTERVENING SEQUENCE RNA OF TETRAHYMENA - INHIBITION BY INTERCALATING DYES.
Nucleic Acids Research.
7741-7758.
1985
-
SELF-CATALYZED CYCLIZATION OF THE INTERVENING SEQUENCE RNA OF TETRAHYMENA - INHIBITION BY METHIDIUMPROPYL.EDTA AND LOCALIZATION OF THE MAJOR DYE BINDING-SITES.
Nucleic Acids Research.
7759-7779.
1985
- SELF-SPLICING OF THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA. The FASEB Journal. R10-R10. 1985
- SELF-SPLICING RNA. ACS National Meeting Book of Abstracts. 85-BIL. 1985
- SELF-SPLICING RNA. Biochemistry. 3370-3371. 1985
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SELF-SPLICING RNA - IMPLICATIONS FOR EVOLUTION.
International review of cytology.
3-22.
1985
-
SEQUENCE REQUIREMENTS FOR SELF-SPLICING OF THE TETRAHYMENA-THERMOPHILA PRE-RIBOSOMAL RNA.
Nucleic Acids Research.
1871-1889.
1985
-
A LABILE PHOSPHODIESTER BOND AT THE LIGATION JUNCTION IN A CIRCULAR INTERVENING SEQUENCE RNA.
Science.
574-578.
1984
-
CHROMATIN STRUCTURE AT THE REPLICATION ORIGINS AND TRANSCRIPTION-INITIATION REGIONS OF THE RIBOSOMAL-RNA GENES OF TETRAHYMENA.
Cell.
933-942.
1984
-
CHROMATIN STRUCTURE OF THE MOLECULAR ENDS OF OXYTRICHA MACRONUCLEAR DNA - PHASED NUCLEOSOMES AND A TELOMERIC COMPLEX.
Cell.
501-510.
1984
-
DNA - PROTEIN INTERACTIONS IN THE DROSOPHILA-VIRILIS MITOCHONDRIAL CHROMOSOME.
Nucleic Acids Research.
1991-1999.
1984
-
SPECIFIC INTERACTION BETWEEN THE SELF-SPLICING RNA OF TETRAHYMENA AND ITS GUANOSINE SUBSTRATE - IMPLICATIONS FOR BIOLOGICAL CATALYSIS BY RNA.
Nature.
820-826.
1984
-
AUTOCATALYTIC CYCLIZATION OF AN EXCISED INTERVENING SEQUENCE RNA IS A CLEAVAGE LIGATION REACTION.
Nature.
578-583.
1983
-
DIFFERENT NUCLEOSOME SPACING IN TRANSCRIBED AND NON-TRANSCRIBED REGIONS OF THE RIBOSOMAL-RNA GENE IN TETRAHYMENA-THERMOPHILA.
Nucleic Acids Research.
2093-2109.
1983
-
FATE OF AN INTERVENING SEQUENCE RIBONUCLEIC-ACID - EXCISION AND CYCLIZATION OF THE TETRAHYMENA RIBOSOMAL RIBONUCLEIC-ACID INTERVENING SEQUENCE INVIVO.
Biochemistry.
2390-2397.
1983
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RNA SPLICING - 3 THEMES WITH VARIATIONS.
Cell.
713-716.
1983
- SECONDARY STRUCTURE OF A SELF-SPLICING RNA. The FASEB Journal. 1884-1884. 1983
-
SECONDARY STRUCTURE OF THE TETRAHYMENA RIBOSOMAL-RNA INTERVENING SEQUENCE - STRUCTURAL HOMOLOGY WITH FUNGAL MITOCHONDRIAL INTERVENING SEQUENCES.
Proceedings of the National Academy of Sciences of USA.
3903-3907.
1983
-
TRANSCRIBED AND NON-TRANSCRIBED REGIONS OF TETRAHYMENA RIBOSOMAL GENE CHROMATIN HAVE DIFFERENT ACCESSIBILITIES TO MICROCOCCAL NUCLEASE.
Nucleic Acids Research.
2077-2091.
1983
-
SELF-SPLICING RNA - AUTO-EXCISION AND AUTO-CYCLIZATION OF THE RIBOSOMAL-RNA INTERVENING SEQUENCE OF TETRAHYMENA.
Cell.
147-157.
1982
-
THE INTERVENING SEQUENCE EXCISED FROM THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA CONTAINS A 5'-TERMINAL GUANOSINE RESIDUE NOT ENCODED BY THE DNA.
Nucleic Acids Research.
2823-2838.
1982
- TRANSCRIBED AND NON-TRANSCRIBED REGIONS OF THE RIBOSOMAL-RNA GENE OF TETRAHYMENA EXHIBIT DIFFERENT CHROMATIN STRUCTURES. The FASEB Journal. 514-514. 1982
- TRANSCRIPTION AND SPLICING OF THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA. 171-204. 1982
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ALKALINE GEL-ELECTROPHORESIS OF DEOXYRIBONUCLEIC-ACID PHOTOREACTED WITH TRIMETHYLPSORALEN - RAPID AND SENSITIVE DETECTION OF INTERSTRAND CROSS-LINKS.
Biochemistry.
1431-1437.
1981
-
INVITRO SPLICING OF THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA - INVOLVEMENT OF A GUANOSINE NUCLEOTIDE IN THE EXCISION OF THE INTERVENING SEQUENCE.
Cell.
487-496.
1981
-
INVITRO SPLICING OF THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA - INVOLVEMENT OF A GUANOSINE NUCLEOTIDE IN THE EXCISION OF THE INTERVENING SEQUENCE.
Cell.
487-496.
1981
-
REPLICATION OF THE EXTRACHROMOSOMAL RIBOSOMAL-RNA GENES OF TETRAHYMENA-THERMOPHILIA.
Nucleic Acids Research.
3531-3543.
1981
- SPLICING OF THE RIBOSOMAL-RNA PRECURSOR AND CYCLIZATION OF THE EXCISED INTERVENING SEQUENCE RNA IN NUCLEI OF TETRAHYMENA. The FASEB Journal. 1651-1651. 1981
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THE INTERVENING SEQUENCE OF THE RIBOSOMAL-RNA PRECURSOR IS CONVERTED TO A CIRCULAR RNA IN ISOLATED-NUCLEI OF TETRAHYMENA.
Cell.
467-476.
1981
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CHROMATIN STRUCTURE OF THE RIBOSOMAL-RNA GENES OF TETRAHYMENA-THERMOPHILA AS ANALYZED BY TRIMETHYLPSORALEN CROSSLINKING INVIVO.
Journal of Molecular Biology.
395-416.
1980
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DNA-PROTEIN INTERACTIONS IN THE DROSOPHILA-MELANOGASTER MITOCHONDRIAL GENOME AS DEDUCED FROM TRIMETHYLPSORALEN CROSSLINKING PATTERNS.
Proceedings of the National Academy of Sciences of USA.
4118-4122.
1980
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INVITRO SPLICING OF THE RIBOSOMAL-RNA PRECURSOR IN NUCLEI OF TETRAHYMENA.
Cell.
331-338.
1980
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An electron microscopic study of the photochemical cross-linking of DNA in guinea pig epidermis by psoralen derivatives.
Biochimica et Biophysica Acta - Section Nucleic Acids And Protein Synthesis.
342-360.
1979
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LOCALIZATION OF TRANSCRIBED REGIONS ON EXTRACHROMOSOMAL RIBOSOMAL-RNA GENES OF TETRAHYMENA-THERMOPHILA BY R-LOOP MAPPING.
Proceedings of the National Academy of Sciences of USA.
5051-5055.
1979
- Chromatin structure in living cells.. 191-8-191-8. 1978
-
Electron microscopy of DNA crosslinked with trimethylpsoralen: a probe for chromatin structure.
Biochemistry.
5313-5321.
1977
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Cross-linking of DNA with trimethylpsoralen is a probe for chromatin structure.
Cell.
631-640.
1977
- Electron microscopy of DNA crosslinked with trimethylpsoralen: test of the secondary structure of eukaryotic inverted repeat sequences.. 2644-8-2644-8. 1976
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ORGANIZATION OF HIGHLY REPEATED SEQUENCES IN MOUSE MAIN-BAND DNA.
Journal of Molecular Biology.
227-256.
1976
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PARTIAL DENATURATION OF MOUSE DNA IN PREPARATIVE CSCL DENSITY GRADIENTS AT ALKALINE PH.
Biochemistry.
1865-1873.
1976
-
STUDY OF DNA DENATURATION IN ULTRACENTRIFUGE.
Biopolymers.
1591-1613.
1976
-
ELECTRON-MICROSCOPIC STUDY OF MOUSE FOLDBACK DNA.
Cell.
429-446.
1975
- Characterization of the rapidly renaturing sequences in the main CsCl density bands of Drosophila, mouse, and human DNA.. 329-39-329-39. 1974
- Characterization of the most rapidly renaturing sequences in mouse main-band DNA.. 299-325-299-325. 1973
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PRC2-RNA interactions: Viewpoint from Tom Cech, Chen Davidovich, and Richard Jenner.
Molecular Cell.
3593-3595.
2024
Teaching
courses taught
-
BCHM 4312 - Quantitative Optical Imaging
Primary Instructor - Fall 2019
Explores the fundamentals of optical imaging in biology, especially molecular and cellular biology. Covered topics include an introduction to optics and microscopes, fluorescence microscopy and image analysis, and biological applications. MATLAB will be taught at the beginning of the course and used throughout for image processing. Prior experience with MATLAB (or Python) is highly recommended but not required. Same as MCDB 4312, MCDB 5312 and BCHM 5312. -
BCHM 5312 - Quantitative Optical Imaging
Primary Instructor - Fall 2019
Explores the fundamentals of optical imaging in biology, especially molecular and cellular biology. Covered topics include an introduction to optics and microscopes, fluorescence microscopy and image analysis, and biological applications. MATLAB will be taught at the beginning of the course and used throughout for image processing. Prior experience with MATLAB (or Python) is highly recommended but not required. Same as MCDB 5312, MCDB 4312 and BCHM 4312. -
BCHM 6901 - Research in Biochemistry
Primary Instructor - Fall 2021 / Fall 2022 / Fall 2023 / Spring 2024 / Fall 2024
May be repeated up to 15 total credit hours. -
MCDB 4312 - Quantitative Optical Imaging
Primary Instructor - Fall 2018 / Fall 2019
Explores the fundamentals of optical imaging in biology, especially molecular and cellular biology. Covered topics include an introduction to optics and microscopes, fluorescence microscopy and image analysis, and biological applications. MATLAB will be taught at the beginning of the course and used throughout for image processing. Prior experience with MATLAB (or Python) is highly recommended but not required. Same as BCHM 4312, MCDB 5312 and BCHM 5312. -
MCDB 4980 - Honors Research
Primary Instructor - Fall 2022
Provides faculty-supervised research for students who have been approved by the departmental honors committee. Normally taken during the semester before completion of the honors thesis. Recommended prerequisite: MCDB 4840 or comparable research experience, and minimum GPA of 3.20. -
MCDB 4990 - Honors Thesis
Primary Instructor - Spring 2019 / Spring 2020 / Fall 2022 / Fall 2024
Involves the preparation and defense of an honors thesis, based on faculty-supervised original research, including final phases of the research project. Recommended prerequisites: MCDB 4840 or MCDB 4980 or comparable research experience, and minimum GPA of 3.3 and approval by the MCDB Honors Committee. -
MCDB 5312 - Quantitative Optical Imaging
Primary Instructor - Fall 2018 / Fall 2019
Explores the fundamentals of optical imaging in biology, especially molecular and cellular biology. Covered topics include an introduction to optics and microscopes, fluorescence microscopy and image analysis, and biological applications. MATLAB will be taught at the beginning of the course and used throughout for image processing. Prior experience with MATLAB (or Python) is highly recommended but not required. Same as BCHM 5312, MCDB 4312 and BCHM 4312.
Background
education and training
- Ph.D., University of California-Berkeley 1975
- B.A., Grinnell College 1970
awards and honors
International Activities
geographic focus
- Australia Country
- Belgium Country
- Canada Country
- China Country
- Czech Republic Country
- France Country
- Germany Country
- Ireland Country
- Japan Country
- Poland Country
- Portugal Country
- Singapore Country
- South Korea Country
- Switzerland Country
- United Kingdom Country