The Anseth group designs biomaterial scaffolds with highly-controlled architectures and chemistries for three-dimensional cell culture, tissue regeneration, and biological assays. We are particularly interested in understanding how cells receive information from their microenvironment and then use this information to design functional biomaterials. Our approach exploits classical engineering principles and modeling, as control is required on many time scales, from seconds to months, and on many size scales, from the molecular to macroscopic. Our research spans the spectrum of fundamental studies to better understand the role of the biomaterial environment on cell function and the biology of tissue formation to targeted clinical applications in the design of in situ forming cell carriers that promote healing. We design materials for both applied clinical applications, as well as advanced in vitro models for drug screening to treat disease.
Biomaterials, regenerative medicine, stem cells and polymer chemistry
CHEN 4805 - Biomaterials
Provides an overview of biomaterials. Covers major classes of materials used in medical applications, properties, degradation mechanisms, and characterization methods, foreign body response, methods to control physiological response to biomaterial surfaces, biocompatibility, biomaterials used in soft and hard tissue replacements, drug delivery devices and tissue engineering, and design criteria for developing a material for a given biological application. Recommended prerequisite: CHEM 3331.
CHEN 5160 - Systems Analysis of Cells and Tissues
Required for the Biological Engineering PhD. This course explores how to describe signaling and regulation networks present at the cell and tissue level. Topics include gene expression, stem cell differentiation, homeostasis, and others. Recommended prerequisite: prior experience in introductory biology and/or biochemistry, linear algebra, differential equations, thermodynamics, and organic chemistry.
CHEN 5919 - Special Topics in CHBE
Spring 2018 / Spring 2019 / Spring 2020 / Fall 2020 / Spring 2022 / Fall 2022 / Spring 2023 / Fall 2023
May be repeated up to 5 total credit hours.