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Publications in VIVO

Hoeffer, Charles Albert

Associate Professor


Research Areas research areas


research overview

  • My research deals with identifying the molecular mechanisms involved in the manifestation of synaptic plasticity and memory in human neurological diseases. I have focused on identifying specific molecular lesions in neuronal signaling pathways and how these play a role in the manifestation of cellular and behavioral deficits in disorders and diseases such as Down syndrome (DS) and Alzheimer’s disease (AD). I use mouse disease and mutant models in combination with behavioral, genetic, and pharmacological approaches to address modeled behavioral deficits and then translate this work to therapies aimed at alleviating human symptoms of neurological disorders and psychiatric disease.


  • Behavior, Psychiatric disease, Animal model, Hippocampus, Molecular signaling, Molecular biology, Neurodegeneration, Alzheimer's disease, Down Syndrome, Schizophrenia, electrophysiology, protein synthesis, Genetics, Transgenic mouse, Anxiety, Calcineurin, Cellular physiology, Translation, GABAergic, Memory, Learning, Synaptic plasticity, Tauopathy


selected publications


courses taught

  • IPHY 4060 - Cell Physiology
    Primary Instructor - Spring 2021 / Fall 2021 / Fall 2023
    Focuses on the molecular machines and cellular sub-compartments that allow cells to renew, replicate, and function in the context of multicellular organisms. Students must enroll in lecture and lab sections.
  • IPHY 4600 - Immunology
    Primary Instructor - Fall 2018 / Fall 2019
    Studies the immune system, a multi-cellular system that functions to protect us from disease. Introduces concepts associated with the development and function of individual cells of the immune system (T-cells, B-cells, neutrophils, dendritic cells, macrophages), as well as their integrative roles in physiology and host defense. This course requires a conceptual understanding of the material and emphasizes problem-solving skills through case studies. Recommended prerequisite: IPHY 3060 or IPHY 4060. Same as IPHY 5600.
  • IPHY 4930 - Internship
    Primary Instructor - Fall 2019 / Spring 2023
    Provides an opportunity for field/laboratory work in a variety of different settings. Consult with faculty for approval. May be repeated up to 6 total credit hours. Department enforced prerequisite: completion of at least two of the major core classes.
  • IPHY 6010 - Seminar
    Primary Instructor - Spring 2019 / Spring 2020
    Presents special topics in integrative physiology. May be repeated up to 6 total credit hours.
  • IPHY 6840 - Research Project
    Primary Instructor - Spring 2020
    Involves a scholarly investigation of a selected topic using literature and/or experimental techniques. Advisor required. May be repeated up to 3 total credit hours.
  • IPHY 6950 - Master's Thesis
    Primary Instructor - Fall 2020 / Spring 2021
    Must have 4 credit hours and may be repeated up to 6 total credits.


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