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Hoeffer, Charles Albert

Associate Professor

Positions

Research Areas research areas

Research

research overview

  • My research deals with identifying the molecular mechanisms involved in the manifestation of synaptic plasticity and memory in human neurological diseases. I have focused on identifying specific molecular lesions in neuronal signaling pathways and how these play a role in the manifestation of cellular and behavioral deficits in disorders and diseases such as Down syndrome (DS) and Alzheimer’s disease (AD). I use mouse disease and mutant models in combination with behavioral, genetic, and pharmacological approaches to address modeled behavioral deficits and then translate this work to therapies aimed at alleviating human symptoms of neurological disorders and psychiatric disease. Our recent studies have expanded into sleep and astrocyte biology.

keywords

  • Behavior, Psychiatric disease, Animal model, Hippocampus, Molecular signaling, Molecular biology, Neurodegeneration, Alzheimer's disease, Down Syndrome, Schizophrenia, Sleep, Astrocytes electrophysiology, protein synthesis, Genetics, Transgenic mouse, Anxiety, Calcineurin, Cellular physiology, Translation, GABAergic, Memory, Learning, Synaptic plasticity, Tauopathy

Publications

selected publications

Teaching

courses taught

  • IPHY 4060 - Cell Physiology
    Primary Instructor - Spring 2021 / Fall 2021 / Fall 2023 / Fall 2024
    Focuses on the molecular machines and cellular sub-compartments that allow cells to renew, replicate, and function in the context of multicellular organisms. Students in lecture section 010 must also enroll in a lab section. The online section of the course may not fulfill prerequisites for post-baccalaureate, graduate, or other allied health programs. Please consult with your Biology advisor before enrollment. Degree credit not granted for this course and IPHY 5060.
  • IPHY 4600 - Immunology
    Primary Instructor - Fall 2018 / Fall 2019
    Studies the immune system, a multi-cellular system that functions to protect us from disease. Introduces concepts associated with the development and function of individual cells of the immune system (T-cells, B-cells, neutrophils, dendritic cells, macrophages), as well as their integrative roles in physiology and host defense. This course requires a conceptual understanding of the material and emphasizes problem-solving skills through case studies. All registration restrictions will be strictly enforced by the department. Recommended prerequisite or corequisite: IPHY 4060. Same as IPHY 5600.
  • IPHY 4930 - Internship
    Primary Instructor - Fall 2019 / Spring 2023
    Offers upper-division students practical experience in laboratory, clinical, and field settings with direct supervision Students can earn 1 credit for every 45 hours of intern work. Consult with departmental internship coordinator for approval. May be repeated up to 6 total credit hours. Department enforced prerequisite: Cumulative GPA of 2.0 and completion of two upper-division IPHY courses.
  • IPHY 6010 - Seminar
    Primary Instructor - Spring 2019 / Spring 2020
    Presents special topics in integrative physiology. May be repeated up to 15 total credits.
  • IPHY 6840 - Research Project
    Primary Instructor - Spring 2020
    Involves a scholarly investigation of a selected topic using literature and/or experimental techniques. Advisor required. May be repeated up to 3 total credit hours.
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