research overview
- The research goals of my laboratory are to determine: 1) important changes in cardiovascular function with aging; 2) modulation of those changes by biological factors and lifestyle behaviors (e.g., physical activity/inactivity, diet); 3) the efficacy of lifestyle and pharmacological interventions for reversing adverse changes in cardiovascular function with aging; 4) the integrative (systemic to molecular) biological mechanisms that mediate cardiovascular changes with aging and the effects of modulating influences and interventions on those changes. Our primary focus is 'vascular aging', in particular the development of large elastic artery stiffness and impaired arterial endothelial function with advancing age. A wide range of contemporary experimental techniques are employed to study these issues in human subjects, rodents, cell culture and via high-throughput molecular analyses.
