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Publications in VIVO

Seals, Doug

Distinguished Professor


Research Areas research areas


research overview

  • The research goals of my laboratory are to determine: 1) important changes in cardiovascular function with aging; 2) modulation of those changes by biological factors and lifestyle behaviors (e.g., physical activity/inactivity, diet); 3) the efficacy of lifestyle and pharmacological interventions for reversing adverse changes in cardiovascular function with aging; 4) the integrative (systemic to molecular) biological mechanisms that mediate cardiovascular changes with aging and the effects of modulating influences and interventions on those changes. Our primary focus is 'vascular aging', in particular the development of large elastic artery stiffness and impaired arterial endothelial function with advancing age. A wide range of contemporary experimental techniques are employed to study these issues in human subjects, rodents, cell culture and via high-throughput molecular analyses.


  • vascular aging, mechanisms of vascular aging, strategies for the prevention and treatment of vascular aging


selected publications


courses taught

  • IPHY 3590 - Health and Function over the Adult Lifespan
    Primary Instructor - Fall 2019
    Examines topics in the field of biomedical aging in the context of public health including: lifespan, changing demographics of aging, healthspan, genetics of aging; physiology of aging (changes in function with age; biological mechanisms of aging); clinical disorders of aging (aging and chronic diseases; clinical syndromes in geriatric medicine); lifestyle and pharmacological strategies for preserving health and function with aging.
  • IPHY 5100 - Colloquium in Integrative Physiology
    Primary Instructor - Fall 2021
    May be repeated up to 6 total credit hours.
  • IPHY 6010 - Seminar
    Primary Instructor - Fall 2018 / Fall 2020
    Presents special topics in integrative physiology. May be repeated up to 6 total credit hours.
  • IPHY 6830 - Professional Skills for the Research Scientist
    Primary Instructor - Fall 2023
    Discusses grant and manuscript writing, scientific presentations, peer-review, setting up/directing a research laboratory, research ethics, mentoring and other professional skills.
  • IPHY 6840 - Research Project
    Primary Instructor - Spring 2018 / Spring 2019 / Spring 2020 / Spring 2021 / Spring 2022 / Spring 2023 / Spring 2024
    Involves a scholarly investigation of a selected topic using literature and/or experimental techniques. Advisor required. May be repeated up to 3 total credit hours.


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