Comparative Hydrogen-Deuterium Exchange for a Mesophilic vs Thermophilic Dihydrofolate Reductase at 25 degrees C: Identification of a Single Active Site Region with Enhanced Flexibility in the Mesophilic Protein
Journal Article
Overview
publication date
- September 27, 2011
has subject area
- Bacterial Proteins
- Binding Sites - Catalytic Domain
- Biochemical Phenomena - Amino Acid Sequence
- Biochemical Phenomena - Sequence Homology, Amino Acid
- Biochemical Phenomena - Structural Homology, Protein
- Deuterium Exchange Measurement
- Endospore-Forming Bacteria - Geobacillus stearothermophilus
- Escherichia coli Proteins
- Firmicutes - Geobacillus stearothermophilus
- Gammaproteobacteria - Escherichia coli
- Genetic Phenomena - Sequence Homology, Amino Acid
- Genetic Phenomena - Structural Homology, Protein
- Gram-Negative Facultatively Anaerobic Rods - Escherichia coli
- Gram-Positive Bacteria - Geobacillus stearothermophilus
- Gram-Positive Bacteria - Geobacillus stearothermophilus
- Gram-Positive Rods - Geobacillus stearothermophilus
- Investigative Techniques - Enzyme Stability
- Models, Molecular
- Molecular Sequence Data
- Molecular Sequence Data - Amino Acid Sequence
- Peptide Fragments
- Protein Conformation
- Protein Conformation - Structural Homology, Protein
- Protein Stability - Enzyme Stability
- Protein Structural Elements - Catalytic Domain
- Recombinant Proteins
- Species Specificity
- Tetrahydrofolate Dehydrogenase
- Thermodynamics
has restriction
- bronze
Date in CU Experts
- September 6, 2013 4:27 AM
Full Author List
- Oyeyemi OA; Sours KM; Lee T; Kohen A; Resing KA; Ahn NG; Klinman JP
author count
- 7
citation count
- 25
published in
- Biochemistry Journal
Other Profiles
International Standard Serial Number (ISSN)
- 0006-2960
Digital Object Identifier (DOI)
Additional Document Info
start page
- 8251
end page
- 8260
volume
- 50
issue
- 38