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Link, Chris

Associate Professor

Positions

Research Areas research areas

Research

research overview

  • The long-term goal of my research is to understand the cellular and molecular basis of age-associated neurodegenerative diseases, particularly Alzheimer's disease (AD) and Amyotrophic Lateral Sclerosis (ALS). Towards this goal, I was the first researcher to develop a transgenic invertebrate model for a human neurodegenerative disease, by engineering C. elegans to express human b-amyloid peptide (Link, 1995). My lab's work in C. elegans demonstrated that TDP-43, a central player in ALS/FTD pathology, limits the accumulation of double-stranded RNA (dsRNA) (Saldi et al, 2014). As mammalian models have improved, and genetic studies have implicated vertebrate-specific functions (e.g., microglia and neuroinflammation) in neurodegenerative diseases, my lab has shifted its focus to mammalian cell culture, human brain immunohistochemistry, and transcriptome analyses, including work with human iPSCs and human brain sequence data.

keywords

  • modeling human neurodegenerative diseases using cellular and C. elegans models

Publications

selected publications

Teaching

courses taught

  • IPHY 3060 - Cell Physiology
    Primary Instructor - Fall 2018
  • IPHY 4060 - Cell Physiology
    Primary Instructor - Fall 2019 / Fall 2020 / Spring 2021 / Fall 2021 / Fall 2022
    Focuses on the molecular machines and cellular sub-compartments that allow cells to renew, replicate, and function in the context of multicellular organisms. Students must enroll in lecture and lab sections.
  • IPHY 4870 - Honors Thesis
    Primary Instructor - Spring 2019
    Department enforced prerequisites: IPHY 2800 and IPHY 3700.
  • IPHY 6010 - Seminar
    Primary Instructor - Spring 2021
    Presents special topics in integrative physiology. May be repeated up to 6 total credit hours.
  • IPHY 6830 - Professional Skills for the Research Scientist
    Primary Instructor - Fall 2019
    Discusses grant and manuscript writing, scientific presentations, peer-review, setting up/directing a research laboratory, research ethics, mentoring and other professional skills.
  • IPHY 6840 - Research Project
    Primary Instructor - Spring 2021
    Involves a scholarly investigation of a selected topic using literature and/or experimental techniques. Advisor required. May be repeated up to 3 total credit hours.

Background

International Activities

geographic focus

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