Publications in VIVO

Co-author Network

Pardi, Arthur

Professor Emerita/Emeritus

Positions

Professor Emerita/Emeritus, Biochemistry

Research Areas

Research

research overview

Dr. Pardi's research focuses on structure-function studies of proteins, nucleic acids and nucleic aicd-protein complexes. Nucleic acid systems currently being studied in the lab include the hammerhead self-cleaving catalytic RNA and various DNA or RNA aptamers that bind with extremely high affinity to the angiogenic regulatory protein VEGF. Nuclear magnetic resonance and other biophysical techniques are used to probe the folding, structure and dynamics of various macromolecules and complexes.

keywords

RNA structure-function,protein structure and function, biophysical chemistry, nucleic acid biochemistry, nuclear magnetic resonance spectroscopy, single molecule spectroscopy

Publications

selected publications

chapter
- NMR Studies of Isotopically Labeled RNA 1994
- Structure of RNA 1994
conference proceeding
- Phosphorylation Releases Constraints to Domain Motion in ERK2. Protein Science. 263-264. 2014
journal article
- Flexibility in the Periplasmic Domain of BamA Is Important for Function. Structure. 94-106. 2017
- Structure-Based Assignment of Ile, Leu, and Val Methyl Groups in the Active and Inactive Forms of the Mitogen-Activated Protein Kinase Extracellular Signal-Regulated Kinase. Biochemistry. 4307-4319. 2015
- Dynamics of Protein Kinases: Insights from Nuclear Magnetic Resonance. Accounts of Chemical Research. 1106-1114. 2015
- Slow Inhibition and Conformation Selective Properties of Extracellular Signal-Regulated Kinase 1 and 2 Inhibitors. Biochemistry. 22-31. 2015
- Optimized Reverse Micelle Surfactant System for High-Resolution NMR Spectroscopy of Encapsulated Proteins and Nucleic Acids Dissolved in Low Viscosity Fluids. Journal of the American Chemical Society. 3465-3474. 2014

Teaching

courses taught

CHEM 4491 - Modern Biophysical Methods
Primary Instructor - Fall 2018
Covers the basic theory of biophysical methods widely employed in biochemistry and biology, including: electrophoresis, mass spec, calorimetry, evanescent waves, plasmon resonance, Xray diffraction, absorbance and fluorescence spectroscopy, magnetic resonance, electron and optical microscopy and single molecule methods. Discusses ways to maximize rigor and reproducibility in biophysical studies. Department enforced prerequisites: undergraduate chemistry (general, organic physical); physics; calculus. Recommended prerequisite or corequisite: BCHM 4400 or CHEM 4531. Same as BCHM 5491.
CHEM 5491 - Modern Biophysical Methods
Primary Instructor - Fall 2018
Covers the basic theory of biophysical methods widely employed in biochemistry and biology, including: electrophoresis, mass spec, calorimetry, evanescent waves, plasmon resonance, Xray diffraction, absorbance and fluorescence spectroscopy, magnetic resonance, electron and optical microscopy and single molecule methods. Discusses ways to maximize rigor and reproducibility in biophysical studies. Same as BCHM 4491. Department enforced prerequisites: undergraduate chemistry (general, organic, physical), biochemistry, physics, calculus.

Background

education and training

Ph.D., University of California-Berkeley 1980
B.A., University of California-San Diego 1976

awards and honors

MERIT (Method to Extend Research in Time) Award, conferred by National Institutes of Health, 2005
Scholar, conferred by Searle Scholars, 1985

Other Profiles

ORCID iD

http://orcid.org/0000-0003-1732-2340