selected publications
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chapter
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conference proceeding
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journal article
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Protective effects of Mycobacterium vaccae ATCC 15483 against "Western"-style diet-induced weight gain and visceral adiposity in adolescent male mice.
Brain, Behavior, and Immunity.
249-267.
2025
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SARS-CoV-2 S1 subunit produces a protracted priming of the neuroinflammatory, physiological, and behavioral responses to a remote immune challenge: A role for corticosteroids.
Brain, Behavior, and Immunity.
87-103.
2024
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Use of adeno-associated viruses for transgenic modulation of microglia structure and function: A review of technical considerations and challenges.
Brain, Behavior, and Immunity.
368-379.
2024
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Use of an immunocapture device to detect cytokine release in discrete brain regions.
Neural Regeneration Research.
703-704.
2024
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Effects of Mycobacterium vaccae NCTC 11659 and Lipopolysaccharide Challenge on Polarization of Murine BV-2 Microglial Cells.
International Journal of Molecular Sciences.
2024
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Interleukin-1beta and inflammasome expression in spinal cord following chronic constriction injury in male and female rats.
Brain, Behavior, and Immunity.
157-168.
2024
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Prior experience with behavioral control over stress facilitates social dominance.
Neurobiology of Stress.
2024
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Exploring the immunogenic properties of SARS-CoV-2 structural proteins: PAMP:TLR signaling in the mediation of the neuroinflammatory and neurologic sequelae of COVID-19.
Brain, Behavior, and Immunity.
259-269.
2023
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Mycobacterium vaccae NCTC 11659, a Soil-Derived Bacterium with Stress Resilience Properties, Modulates the Proinflammatory Effects of LPS in Macrophages.
International Journal of Molecular Sciences.
2023
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Immunization with a heat-killed preparation of Mycobacterium vaccae NCTC 11659 enhances auditory-cued fear extinction in a stress-dependent manner.
Brain, Behavior, and Immunity.
1-15.
2023
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SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: Evidence of PAMP-like properties.
Brain, Behavior, and Immunity.
267-277.
2022
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Comparing the effects of two different strains of mycobacteria, Mycobacterium vaccae NCTC 11659 and M. vaccae ATCC 15483, on stress-resilient behaviors and lipid-immune signaling in rats.
Brain, Behavior, and Immunity.
212-229.
2021
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Acute stress induces the rapid and transient induction of caspase-1, gasdermin D and release of constitutive IL-1 beta protein in dorsal hippocampus.
Brain, Behavior, and Immunity.
70-80.
2020
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Acute stress induces chronic neuroinflammatory, microglial and behavioral priming: A role for potentiated NLRP3 inflammasome activation.
Brain, Behavior, and Immunity.
32-42.
2020
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Alzheimer's Disease: Protective Effects of Mycobacterium vaccae, a Soil-Derived Mycobacterium with Anti-Inflammatory and Anti-Tubercular Properties, on the Proteomic Profiles of Plasma and Cerebrospinal Fluid in Rats.
Journal of Alzheimer's Disease.
965-987.
2020
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Microglia: Neuroimmune-sensors of stress.
Seminars in Cell and Developmental Biology.
176-185.
2019
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Ebola in the DRC one year later - Boiling the frog?.
International Journal of Infectious Diseases.
212-213.
2019
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Glucocorticoids mediate stress induction of the alarmin HMGB1 and reduction of the microglia checkpoint receptor CD200R1 in limbic brain structures.
Brain, Behavior, and Immunity.
678-687.
2019
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Could Probiotics Be Used to Mitigate Neuroinflammation?.
ACS Chemical Neuroscience.
13-15.
2019
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Mycobacterium vaccae immunization protects aged rats from surgery-elicited neuroinflammation and cognitive dysfunction.
Neurobiology of Aging.
105-114.
2018
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Immunization with Mycobacterium vaccae induces an anti-inflammatory milieu in the CNS: Attenuation of stress-induced microglial priming, alarmins and anxiety-like behavior.
Brain, Behavior, and Immunity.
352-363.
2018
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Stress and aging act through common mechanisms to elicit neuroinflammatory priming.
Brain, Behavior, and Immunity.
133-148.
2018
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A novel platform for in vivo detection of cytokine release within discrete brain regions.
Brain, Behavior, and Immunity.
18-22.
2018
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Pattern recognition receptors mediate pro-inflammatory effects of extracellular mitochondrial transcription factor A (TFAM).
Molecular and Cellular Neuroscience.
71-79.
2018
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Neuroinflammatory priming to stress is differentially regulated in male and female rats.
Brain, Behavior, and Immunity.
257-267.
2018
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Stress disinhibits microglia via down-regulation of CD200R: A mechanism of neuroinflammatory priming.
Brain, Behavior, and Immunity.
62-73.
2018
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Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders.
Neuropsychopharmacology.
36-45.
2017
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Stress-induced neuroinflammatory priming: A liability factor in the etiology of psychiatric disorders.
Neurobiology of Stress.
62-70.
2016
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The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming.
The Journal of Neuroscience.
7946-7956.
2016
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Glucocorticoids Mediate Short-Term High-Fat Diet Induction of Neuroinflammatory Priming, the NLRP3 Inflammasome, and the Danger Signal HMGB1.
eNeuro.
2016
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The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: A role for the NLRP3 inflammasome.
Brain, Behavior, and Immunity.
215-224.
2016
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Stress-induced neuroinflammatory priming is time of day dependent.
Psychoneuroendocrinology.
82-90.
2016
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The danger-associated molecular pattern HMGB1 mediates the neuroinflammatory effects of methamphetamine.
Brain, Behavior, and Immunity.
99-108.
2016
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Stress sounds the alarmin: The role of the danger-associated molecular pattern HMGB1 in stress-induced neuroinflammatory priming.
Brain, Behavior, and Immunity.
1-7.
2015
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The permissive role of glucocorticoids in neuroinflammatory priming: mechanisms and insights.
Current Opinion in Endocrinology, Diabetes and Obesity.
300-305.
2015
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Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia.
Neurobiology of Aging.
1483-1495.
2015
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Microglia inflammatory responses are controlled by an intrinsic circadian clock.
Brain, Behavior, and Immunity.
171-179.
2015
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Stress Induces the Danger-Associated Molecular Pattern HMGB-1 in the Hippocampus of Male Sprague Dawley Rats: A Priming Stimulus of Microglia and the NLRP3 Inflammasome.
The Journal of Neuroscience.
316-324.
2015
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The role of hepatic and splenic macrophages in E. coli-induced memory impairments in aged rats.
Brain, Behavior, and Immunity.
60-67.
2015
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Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis.
Molecular Psychiatry.
699-709.
2014
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Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus.
Psychoneuroendocrinology.
191-200.
2014
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Stress-induced glucocorticoids as a neuroendocrine alarm signal of danger.
Brain, Behavior, and Immunity.
1-6.
2013
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Blocking toll-like receptor 2 and 4 signaling during a stressor prevents stress-induced priming of neuroinflammatory responses to a subsequent immune challenge.
Brain, Behavior, and Immunity.
112-121.
2013
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IL-1RA injected intra-cisterna magna confers extended prophylaxis against lipopolysaccharide-induced neuroinflammatory and sickness responses.
Journal of Neuroimmunology.
33-39.
2012
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Intracisternal Interleukin-1 Receptor Antagonist Prevents Postoperative Cognitive Decline and Neuroinflammatory Response in Aged Rats.
The Journal of Neuroscience.
14641-14648.
2012
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Aging-related changes in neuroimmune-endocrine function: Implications for hippocampal-dependent cognition.
Hormones and Behaviour.
219-227.
2012
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Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses.
Brain, Behavior, and Immunity.
337-345.
2012
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Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors.
Journal of Neuroimmunology.
53-60.
2011
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Uncontrollable, But Not Controllable, Stress Desensitizes 5-HT1A Receptors in the Dorsal Raphe Nucleus.
The Journal of Neuroscience.
14107-14115.
2011
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Prior exposure to glucocorticoids potentiates lipopolysaccharide induced mechanical allodynia and spinal neuroinflammation.
Brain, Behavior, and Immunity.
1408-1415.
2011
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Little Exercise, Big Effects: Reversing Aging and Infection-Induced Memory Deficits, and Underlying Processes.
The Journal of Neuroscience.
11578-11586.
2011
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Stress- and glucocorticoid-induced priming of neuroinflammatory responses: Potential mechanisms of stress-induced vulnerability to drugs of abuse.
Brain, Behavior, and Immunity.
S21-S28.
2011
- Memory Impairments in Healthy Aging: Role of Aging-Induced Microglial Sensitization. Aging and Disease. 212-231. 2010
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Pain Intensity and Duration Can Be Enhanced by Prior Challenge: Initial Evidence Suggestive of a Role of Microglial Priming.
Journal of Pain.
1004-1014.
2010
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Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo.
Journal of Neuroimmunology.
181-184.
2010
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Release of Plasmid DNA-Encoding IL-10 from PLGA Microparticles Facilitates Long-Term Reversal of Neuropathic Pain Following a Single Intrathecal Administration.
Pharmaceutical Research.
841-854.
2010
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IL-1RA blocks E. coli-induced suppression of Arc and long-term memory in aged F344 x BN F1 rats.
Brain, Behavior, and Immunity.
254-262.
2010
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Prior exposure to glucocorticoids sensitizes the neuroinflammatory and peripheral inflammatory responses to E. coli lipopolysaccharide.
Brain, Behavior, and Immunity.
19-30.
2010
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Time course of hippocampal IL-1 β and memory consolidation impairments in aging rats following peripheral infection.
Brain, Behavior, and Immunity.
46-54.
2009
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Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120.
Brain, Behavior, and Immunity.
660-667.
2007
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Stress-induced glucocorticoids suppress the antisense molecular regulation of FGF-2 expression.
Psychoneuroendocrinology.
376-384.
2007
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Characterization of the temporo-spatial effects of chronic bilateral intrahippocampal cannulae on interleukin-1 beta.
Journal of Neuroscience Methods.
265-272.
2007
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Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses.
Brain, Behavior, and Immunity.
47-59.
2007
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Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain.
Pain.
294-308.
2006
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mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging.
Neurobiology of Aging.
717-722.
2006
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Rapid isolation of highly enriched and quiescent microglia from adult rat hippocampus: Immunophenotypic and functional characteristics.
Journal of Neuroscience Methods.
121-130.
2006
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Specific and time-dependent effects of glucocorticoid receptor agonist RU28362 on stress-induced pro-opiomelanocortin hnRNA, c-fos mRNA and zif268 mRNA in the pituitary.
Journal of Neuroendocrinology.
129-138.
2006
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Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation.
Pain.
71-83.
2005
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A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine.
The Journal of Neuroscience.
7353-7365.
2004
- Spinal interleukin-10 (IL-10) gene therapy using viral and non-viral vectors controls inflammatory- and chronic constriction injury-induced pain states in rats. Molecular Therapy. S200-S201. 2004
... more -
Protective effects of Mycobacterium vaccae ATCC 15483 against "Western"-style diet-induced weight gain and visceral adiposity in adolescent male mice.
Brain, Behavior, and Immunity.
249-267.
2025