My research investigates the molecular mechanisms of membrane trafficking to lysosomes, which have a major role in protein degradation. These trafficking pathways include the AP-3 pathway from the Golgi to the lysosome and the ESCRT pathway, which buds transport vesicle into the endosome lumen for subsequent delivery to the lysosome lumen.
keywords
membrane trafficking, membrane scission, membrane tethering, membrane fusion, protein ubiquitination, protein deubiquitination, vesicle budding, vesicle docking, vesicle fusion, Golgi, ion transport, vacuole, lysosome, osmotic homeostasis, phosphoinositides
