p16 expression confers sensitivity to CDK2 inhibitors in cyclin E1-driven ovarian cancers
Journal Article
Overview
publication date
- November 25, 2025
has subject area
- Adnexal Diseases - Ovarian Neoplasms
- Animals
- Biochemical Phenomena - Signal Transduction
- Cell Cycle Proteins - Cyclin E
- Cell Cycle Proteins - Cyclin-Dependent Kinase 2
- Cell Cycle Proteins - Cyclin-Dependent Kinase 4
- Cell Cycle Proteins - Cyclin-Dependent Kinase 6
- Cell Cycle Proteins - Cyclin-Dependent Kinase Inhibitor p16
- Cell Line - Cell Line, Tumor
- Cell Physiological Phenomena - Cell Proliferation
- Cell Physiological Phenomena - Signal Transduction
- Drug Resistance, Neoplasm
- Endocrine System Diseases - Ovarian Neoplasms
- Female
- Female Urogenital Diseases - Ovarian Neoplasms
- Gene Expression Regulation, Neoplastic
- Gonadal Disorders - Ovarian Neoplasms
- Growth - Cell Proliferation
- Humans
- Mice
- Neoplasms by Site - Ovarian Neoplasms
- Oncogene Proteins
- Peptides - Cyclin E
- Peptides - Cyclin-Dependent Kinase 2
- Peptides - Cyclin-Dependent Kinase 4
- Peptides - Cyclin-Dependent Kinase 6
- Peptides - Cyclin-Dependent Kinase Inhibitor p16
- Proline-Directed Protein Kinases - Cyclin-Dependent Kinase 2
- Proline-Directed Protein Kinases - Cyclin-Dependent Kinase 4
- Proline-Directed Protein Kinases - Cyclin-Dependent Kinase 6
- Protein Kinase Inhibitors
- Proteins - Cyclin E
- Proteins - Cyclin-Dependent Kinase 2
- Proteins - Cyclin-Dependent Kinase 4
- Proteins - Cyclin-Dependent Kinase 6
- Proteins - Cyclin-Dependent Kinase Inhibitor p16
- Tumor Cells, Cultured - Cell Line, Tumor
- Tumor Suppressor Proteins - Cyclin-Dependent Kinase Inhibitor p16
Date in CU Experts
- November 26, 2025 9:44 AM
Full Author List
- Sine CC; Watts LP; Fernandez B; Marikar N; Wang J; Knudsen ES; Witkiewicz AK; Spencer SL
author count
- 8
citation count
- 3
published in
- Science Signaling Journal
Other Profiles
International Standard Serial Number (ISSN)
- 1945-0877
Electronic International Standard Serial Number (EISSN)
- 1937-9145
Digital Object Identifier (DOI)
Additional Document Info
volume
- 18
issue
- 914
number
- ARTN eadv0415