Loss of the trpc4 gene is associated with a reduction in cocaine self-administration and reduced spontaneous ventral tegmental area dopamine neuronal activity, without deficits in learning for natural rewards
Journal Article
Overview
publication date
- June 1, 2016
has subject area
- Alkaloids - Cocaine
- Animal Population Groups - Rats, Transgenic
- Animals
- Animals, Inbred Strains - Rats, Inbred F344
- Aza Compounds - Cocaine
- Biophysical Phenomena - Membrane Potentials
- Bridged Bicyclo Compounds, Heterocyclic - Cocaine
- Carrier Proteins - TRPC Cation Channels
- Cell Physiological Phenomena - Membrane Potentials
- Cells - Dopaminergic Neurons
- Conditioning, Operant
- Drug Therapy - Self Administration
- Electrophysiological Phenomena - Membrane Potentials
- Female
- Gene Expression Regulation
- Heterocyclic Compounds, Bridged-Ring - Cocaine
- Male
- Maze Learning
- Membrane Proteins - TRPC Cation Channels
- Membrane Transport Modulators - Dopamine Uptake Inhibitors
- Metalloproteins - Tyrosine 3-Monooxygenase
- Mixed Function Oxygenases - Tyrosine 3-Monooxygenase
- Molecular Mechanisms of Pharmacological Action - Dopamine Uptake Inhibitors
- Molecular Mechanisms of Pharmacological Action - Dopamine Uptake Inhibitors
- Nervous System - Dopaminergic Neurons
- Nervous System Physiological Phenomena - Membrane Potentials
- Oligosaccharides - Sucrose
- Physiological Effects of Drugs - Dopamine Uptake Inhibitors
- Physiological Effects of Drugs - Dopamine Uptake Inhibitors
- Rats
- Rats - Rats, Inbred F344
- Rats - Rats, Transgenic
- Reinforcement Schedule
- Reward
- Sugars - Sucrose
- Therapeutics - Self Administration
- Ventral Tegmental Area
has restriction
- closed
Date in CU Experts
- March 24, 2016 2:34 AM
Full Author List
- Klipec WD; Burrow KR; O'Neill C; Cao J-L; Lawyer CR; Ostertag E; Fowler M; Bachtell RK; Illig KR; Cooper DC
author count
- 10
citation count
- 3
published in
- Behavioural Brain Research Journal
Other Profiles
International Standard Serial Number (ISSN)
- 0166-4328
Electronic International Standard Serial Number (EISSN)
- 1872-7549
Digital Object Identifier (DOI)
Additional Document Info
start page
- 117
end page
- 127
volume
- 306