keywords
- traumatic brain injury, sleep, inflammation, microglia, aging, neurodegenerative diseases
- Contact Info
Rowe, Rachel Kathleen
Positions
- Assistant Professor, Integrative Physiology
Research Areas
Research
Publications
selected publications
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chapter
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Fluid Percussion Model of Traumatic Brain Injury.
Neuromethods.
97-110.
2018
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Midline (Central) Fluid Percussion Model of Traumatic Brain Injury.
Methods in Molecular Biology.
211-230.
2016
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Fluid Percussion Model of Traumatic Brain Injury.
Neuromethods.
97-110.
2018
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conference proceeding
- Traumatic brain injury characteristics predictive of subsequent sleep-wake disturbances in pediatric patients. Brain Injury. 223-224. 2023
- ALPHA-II SPECTRIN N-TERMINAL FRAGMENT (SNTF) DETECTS AXONAL PATHOLOGY IN CHRONIC EXPERIMENTAL TRAUMATIC BRAIN INJURY. Journal of Neurotrauma. A108-A108. 2023
- DIFFUSE TRAUMATIC BRAIN INJURY ALTERED FUNCTION OF THE GROWTH HORMONE AXIS IN JUVENILE RATS. Journal of Neurotrauma. A71-A71. 2023
- METHODS MATTER: MECHANISM OF TRAUMATIC BRAIN INJURY DRIVES SUBSTANTIAL POST-TRAUMATIC SLEEP DIFFERENCES. Journal of Neurotrauma. A71-A71. 2023
- NOVEL SPATIAL QUANTIFICATION SHOWED GLIALNEURON INTERACTIONS AFTER TBI. Journal of Neurotrauma. A70-A71. 2023
- POST INJURY SLEEP FRAGMENTATION STRESS INCREASES NEUROINFLAMMATORY RESPONSE AND IMPAIRS BEHAVIORAL RECOVERY. Journal of Neurotrauma. A135-A135. 2023
- SEX DIFFERENCES IN SLEEP: BIOLOGICAL SEX AND BRAIN INJURY SEVERITY IMPACT SLEEP IN THE MOUSE. Journal of Neurotrauma. A71-A71. 2023
- TBI-INDUCED SENSORIMOTOR DEFICITS DIFFER AS A FUNCTION OF SEX AND INJURY SEVERITY. Journal of Neurotrauma. A7-A7. 2023
- BLOOD-BRAIN BARRIER DYSFUNCTION PREDICTS MICROGLIAL ACTIVATION FOLLOWING TBI IN JUVENILE RATS. Journal of Neurotrauma. A77-A77. 2022
- FIBRILLIN-1 MUTATION ACCELERATES CEREBROVASCULAR AGING AND INCREASES NEUROVASCULAR VULNERABILITY TO MILD TRAUMATIC BRAIN INJURY. Journal of Neurotrauma. A5-A6. 2022
- SLEEP FRAGMENTATION FOLLOWING TRAUMATIC BRAIN INJURY EXACERBATES SUB-ACUTE BEHAVIORAL DEFICITS AND TRANSCRIPTIONAL CHANGES AT CHRONIC TIME POINTS. Journal of Neurotrauma. A2-A2. 2022
- TRAUMATIC BRAIN INJURY CHARACTERISTICS PREDICTIVE OF SUBSEQUENT SLEEP-WAKE DISTURBANCES IN PEDIATRIC PATIENTS. Journal of Neurotrauma. A85-A85. 2022
- A GENE THERAPY APPROACH TO TREAT PERSISTENT PAIN DERIVED FROM SPINAL STUDIES OF RODENTS AND MONKEYS. Journal of Neurotrauma. A121-A121. 2021
- AGING WITH BRAIN INJURY: AGE-AT-INJURY INFLUENCES THE GLIAL RESPONSE TO TBI IN JUVENILES. Journal of Neurotrauma. A60-A60. 2021
- COLONY STIMULATING FACTOR-1 RECEPTOR INHIBITION AS A PHARMACODYNAMIC MECHANISM TO TRACK PERIPHERAL INFLAMMATION AFTER TBI. Journal of Neurotrauma. A12-A12. 2021
- INCREASED TGF-B/MMP LEVELS ACCELERATE CEREBROVASCULAR AGING, LEAVING THE BRAIN MORE VULNERABLE TO TBI. Journal of Neurotrauma. A68-A69. 2021
- REM SLEEP IS DISRUPTED FOLLOWING PEDIATRIC TBI. Journal of Neurotrauma. A107-A107. 2021
- AGING WITH BRAIN INJURY: AGE-AT-INJURY INFLUENCES THE GLIAL RESPONSE TO TBI IN JUVENILES. Journal of Neurotrauma. A6-A7. 2021
- A NOVEL GLYCOSYLATED PITUITARY ADENYLATE CYCLASE-ACTIVATING PEPTIDE ATTENUATED FUNCTIONAL DEFICITS FOLLOWING EXPERIMENTAL TBI. Journal of Neurotrauma. A91-A91. 2019
- ASSOCIATED RISK FACTORS TO PREDICT PEDIATRIC NON-ACCIDENTAL HEAD TRAUMA. Journal of Neurotrauma. A138-A138. 2019
- DIFFUSE BRAIN INJURY INDUCED BIOMARKERS ASSOCIATED WITH TOXIC PROTEIN VARIANTS FOUND IN ALZHEIMER'S DISEASE AND RELATED DEMENTIA. Journal of Neurotrauma. A30-A30. 2019
- DISSECTING MOLECULAR MECHANISM AND THERAPEUTIC IMPACT OF REMOTE ISCHEMIC CONDITIONING IN A MOUSE MODEL OF DIFFUSE TRAUMATIC BRAIN. Journal of Neurotrauma. A124-A125. 2019
- MICE BORN TO MOTHERS WITH GESTATIONAL BRAIN INJURY HAVE DISTORTED BRAIN CIRCUITRY AND DIFFERENTIAL IMMUNE RESPONSES. Journal of Neurotrauma. A137-A138. 2019
- REMOTE ISCHEMIC CONDITIONING PREVENTS TRAUMATIC BRAIN INJURY-INDUCED ACUTE LUNG INJURY. Journal of Neurotrauma. A7-A8. 2019
- SELF-GUIDED REHABILITATION IMPROVED COGNITIVE PERFORMANCE AFTER DIFFUSE TRAUMATIC BRAIN INJURY IN JUVENILE RATS. Journal of Neurotrauma. A138-A138. 2019
- TRAUMATIC BRAIN INJURY AND ALZHEIMER'S DISEASE IN AGED MICE LEADS TO SIMILAR INCREASES IN SLEEP AND PERIPHERAL CD115 EXPRESSION. Journal of Neurotrauma. A23-A23. 2019
- CLINICAL OBSERVATION INFORMS TRANSLATIONAL RESEARCH OF GROWTH HORMONE AXIS DISRUPTION FOLLOWING DIFFUSE TBI IN JUVENILE RATS. Journal of Neurotrauma. A112-A112. 2018
- GLIAL ENGAGEMENT AT THE HEMATOMA AFTER INTRACEREBRAL HEMORRHAGE IN THE MOUSE. Journal of Neurotrauma. A124-A124. 2018
- NEUROINFLAMMATION AND ACUTE SLEEP DISTURBANCES FOLLOWING EXPERIMENTAL INTRACEREBRAL HEMORRHAGE. Journal of Neurotrauma. A263-A263. 2018
- PRE-PUBERTY AND PERI-PUBERTY TBI: AGE AT INJURY EFFECTS ON HISTOPATHOLOGICAL OUTCOMES FOLLOWING DIFFUSE BRAIN INJURY IN RATS. Journal of Neurotrauma. A133-A133. 2018
- REMOTE ISCHEMIC CONDITIONING ATTENUATES THE PERIPHERAL COMPONENT OF NEUROINFLAMMATION IN DIFFUSE BRAIN-INJURED IN FEMALE MICE. Journal of Neurotrauma. A222-A222. 2018
- SEXUAL DIMORPHISM IN ACUTE INFLAMMATION AND POST-TRAUMATIC SLEEP FOLLOWING DIFFUSE TRAUMATIC BRAIN INJURY IN THE MOUSE. Journal of Neurotrauma. A125-A125. 2018
- TRAUMATIC BRAIN INJURY-INDUCED NEURONAL DAMAGE INDUCES CORTICAL ROD MICROGLIA THAT PROMOTE PERSISTENT NEUROINFLAMMATION. Journal of Neurotrauma. A12-A13. 2018
- AGE-AT-INJURY AFFECTS CHRONIC DIFFUSE TRAUMATIC BRAIN INJURY AND ALZHEIMER'S DISEASE RELATED BEHAVIORS AND PATHOLOGIES. Journal of Neurotrauma. A12-A12. 2017
- INVESTIGATION OF NANOPARTICLE ACCUMULATION AFTER EXPERIMENTAL BRAIN INJURY. Journal of Neurotrauma. A26-A26. 2016
- ACUTE OVER-THE-COUNTER PHARMACOLOGICAL INTERVENTION DOES NOT ADVERSELY AFFECT BEHAVIORAL OUTCOME FOLLOWING DIFFUSE TRAUMATIC BRAIN. Journal of Neurotrauma. A109-A109. 2014
- EXPERIMENTAL DIFFUSE BRAIN INJURY LEADS TO CHRONIC ENDOCRINE DYSFUNCTION. Journal of Neurotrauma. A99-A99. 2014
- MIDLINE FLUID PERCUSSION INJURY IN THE DEVELOPING RODENT RESULTS IN DIFFUSE INJURY AND DEVIATION OF THE NEUROVASCULAR UNIT. Journal of Neurotrauma. A64-A64. 2014
- REMOTE ISCHEMIC CONDITIONING AS PRE-HOSPITAL THERAPEUTIC INTERVENTION FOR DIFFUSE TRAUMATIC BRAIN INJURY. Journal of Neurotrauma. A109-A109. 2014
- EXPERIMENTAL DIFFUSE BRAIN INJURY DOES NOT IMPACT CHRONIC SLEEP PATTERNS. Journal of Neurotrauma. A127-A128. 2013
- IMMEDIATE POST-INJURY SLEEP DISRUPTION DOES NOT AFFECT FUNCTIONAL OUTCOME FOLLOWING DIFFUSE BRAIN INJURY IN MICE. Journal of Neurotrauma. A9-A10. 2013
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journal article
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Quantifying Microglial Morphology: An Insight into Function..
Clinical and Experimental Immunology.
2024
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Blood-Brain Barrier Dysfunction Predicts Microglial Activation After Traumatic Brain Injury in Juvenile Rats.
Neurotrauma Reports.
95-116.
2024
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Diffuse traumatic brain injury substantially alters plasma growth hormone in the juvenile rat.
Journal of Endocrinology.
2024
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Traumatic brain injury in mice generates early-stage Alzheimer's disease related protein pathology that correlates with neurobehavioral deficits.
2023
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Colony-Stimulating Factor-1 Receptor Inhibition Transiently Attenuated the Peripheral Immune Response to Experimental Traumatic Brain Injury.
Neurotrauma Reports.
284-296.
2023
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Comparisons of quantitative approaches for assessing microglial morphology reveal inconsistencies, ecological fallacy, and a need for standardization.
Scientific Reports.
2022
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Reactive morphology of dividing microglia following kainic acid administration.
Frontiers in Neuroscience.
2022
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Microglia Are Necessary to Regulate Sleep after an Immune Challenge.
Biology.
2022
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Immune-endocrine interactions in the pathophysiology of sleep-wake disturbances following traumatic brain injury: A narrative review.
Brain Research Bulletin.
117-128.
2022
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Intimate Partner Violence, Clinical Indications, and Other Family Risk Factors Associated With Pediatric Abusive Head Trauma.
Journal of Interpersonal Violence: concerned with the study and treatment of victims and perpetrators of physical and sexual violence.
NP6785-NP6812.
2022
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Time Course of Remote Neuropathology Following Diffuse Traumatic Brain Injury in the Male Rat.
Experimental neurobiology.
105-115.
2022
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Traumatic Brain Injury Characteristics Predictive of Subsequent Sleep-Wake Disturbances in Pediatric Patients.
Biology.
2022
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Age-At-Injury Influences the Glial Response to Traumatic Brain Injury in the Cortex of Male Juvenile Rats.
Frontiers in Neurology.
2022
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Design and Synthesis of Brain Penetrant Glycopeptide Analogues of PACAP With Neuroprotective Potential for Traumatic Brain Injury and Parkinsonism.
2022
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Mice Born to Mothers with Gravida Traumatic Brain Injury Have Distorted Brain Circuitry and Altered Immune Responses.
Journal of Neurotrauma.
2862-2880.
2021
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Age-at-Injury Determines the Extent of Long-Term Neuropathology and Microgliosis After a Diffuse Brain Injury in Male Rats.
Frontiers in Neurology.
2021
- POPULATION-LEVEL EPIDEMIOLOGY OF CONCUSSION CONCURRENT WITH DOMESTIC VIOLENCE IN ARIZONA, USA. Journal of Neurotrauma. A34-A34. 2021
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Experimental diffuse brain injury and a model of Alzheimer's disease exhibit disease-specific changes in sleep and incongruous peripheral inflammation.
Journal of Neuroscience Research.
1136-1160.
2021
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Evaluating abusive head trauma in children < 5 years old: Risk factors and the importance of the social history.
Journal of Pediatric Surgery.
390-396.
2021
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Remote Ischemic Conditioning Reduced Acute Lung Injury After Traumatic Brain Injury in the Mouse.
Shock.
256-267.
2021
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Failure to Thrive in a 15-month-old with a History of Head Trauma..
Pediatrics in Review.
S55-S59.
2021
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Spatial Distribution of Neuropathology and Neuroinflammation Elucidate the Biomechanics of Fluid Percussion Injury.
Neurotrauma Reports.
59-75.
2021
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Sex-Dependent Pathology in the HPA Axis at a Sub-acute Period After Experimental Traumatic Brain Injury.
Frontiers in Neurology.
2020
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The Bidirectional Relationship Between Sleep and Inflammation Links Traumatic Brain Injury and Alzheimer's Disease.
Frontiers in Neuroscience.
2020
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Proteomic analysis identifies plasma correlates of remote ischemic conditioning in the context of experimental traumatic brain injury.
Scientific Reports.
2020
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Acute peripheral inflammation and post-traumatic sleep differ between sexes after experimental diffuse brain injury.
European Journal of Neuroscience.
2791-2814.
2020
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Longitudinal optical imaging technique to visualize progressive axonal damage after brain injury in mice reveals responses to different minocycline treatments.
Scientific Reports.
2020
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Intracerebral hemorrhage in the mouse altered sleep-wake patterns and activated microglia.
Experimental Neurology.
2020
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Epidemiology of Pediatric Traumatic Brain Injury and Hypothalamic-Pituitary Disorders in Arizona.
Frontiers in Neurology.
2020
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Mild and Moderate Traumatic Brain Injury and Repeated Stress Affect Corticosterone in the Rat.
Neurotrauma Reports.
113-124.
2020
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Acute Post-Traumatic Sleep May Define Vulnerability to a Second Traumatic Brain Injury in Mice.
Journal of Neurotrauma.
1318-1334.
2019
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Influence of Schizophrenia-Associated Gene Egr3 on Sleep Behavior and Circadian Rhythms in Mice.
Journal of Biological Rhythms.
662-670.
2018
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Traumatic brain injury-induced neuronal damage in the somatosensory cortex causes formation of rod-shaped microglia that promote astrogliosis and persistent neuroinflammation.
Glia.
2719-2736.
2018
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Blood-brainbarrier disruption dictates nanoparticle accumulation following experimental brain injury.
Nanomedicine: Nanotechnology, Biology and Medicine.
2155-2166.
2018
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Simultaneous Cryosectioning of Multiple Rodent Brains.
Journal of Visualized Experiments.
2018
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Partial cage division significantly reduces aggressive behavior in male laboratory mice.
Laboratory Animals.
384-393.
2018
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Midline (central) fluid percussion model of traumatic brain injury in pediatric and adolescent rats.
Journal of Neurosurgery: Pediatrics.
22-30.
2018
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Novel TNF receptor-1 inhibitors identified as potential therapeutic candidates for traumatic brain injury.
Journal of Neuroinflammation.
2018
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Quantitative microglia analyses reveal diverse morphologic responses in the rat cortex after diffuse brain injury.
Scientific Reports.
2017
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Aging with a traumatic brain injury: Could behavioral morbidities and endocrine symptoms be influenced by microglial priming?.
Brain, Behavior, and Immunity.
1-7.
2017
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Diffuse traumatic brain injury affects chronic corticosterone function in the rat.
Endocrine Connections.
152-166.
2016
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Diffuse traumatic brain injury induces prolonged immune dysregulation and potentiates hyperalgesia following a peripheral immune challenge.
Molecular Pain.
2016
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MW151 Inhibited IL-1 beta Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses.
PLoS One.
2016
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Experimental diffuse brain injury results in regional alteration of gross vascular morphology independent of neuropathology.
Brain Injury.
217-224.
2016
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Aging with Traumatic rain Injury: Effects of Age at Injury on Behavioral Outcome following Diffuse Brain Injury in Rats.
Developmental Neuroscience.
195-205.
2016
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Clinical relevance of midline fluid percussion brain injury: Acute deficits, chronic morbidities and the utility of biomarkers.
Brain Injury.
1293-1301.
2016
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Lipid mediators of inflammation in neurological injury: shifting the balance toward resolution.
Neural Regeneration Research.
77-78.
2016
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Resolvins AT-D1 and E1 differentially impact functional outcome, post-traumatic sleep, and microglial activation following diffuse brain injury in the mouse.
Brain, Behavior, and Immunity.
131-140.
2015
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Acute over-the-counter pharmacological intervention does not adversely affect behavioral outcome following diffuse traumatic brain injury in the mouse.
Experimental Brain Research.
2709-2719.
2014
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Diffuse brain injury does not affect chronic sleep patterns in the mouse.
Brain Injury.
504-510.
2014
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Recovery of Neurological Function Despite Immediate Sleep Disruption Following Diffuse Brain Injury in the Mouse: Clinical Relevance to Medically Untreated Concussion.
Sleep.
743-752.
2014
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Diffuse Brain Injury Induces Acute Post-Traumatic Sleep.
PLoS One.
2014
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Using anesthetics and analgesics in experimental traumatic brain injury.
Lab Animal.
286-291.
2013
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The p38α MAPK Regulates Microglial Responsiveness to Diffuse Traumatic Brain Injury.
The Journal of Neuroscience.
6143-6153.
2013
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EVALUATION OF RIGHT SUBPHRENIC FLUID COLLECTIONS WITH EMISSION COMPUTED-TOMOGRAPHY - AN EXPERIMENTAL-STUDY.
Computerized radiology : official journal of the Computerized Tomography Society.
319-323.
1985
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Quantifying Microglial Morphology: An Insight into Function..
Clinical and Experimental Immunology.
2024
Teaching
courses taught
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IPHY 4010 - Seminar in Integrative Physiology
Primary Instructor - Spring 2023
Introduces a small group of students to current research topics in integrative physiology, evaluation of current research and discussion of critical issues. May be repeated up to 6 total credit hours when topics vary. Department enforced prerequisite: IPHY 2800 or equivalent. -
IPHY 4870 - Honors Thesis
Primary Instructor - Spring 2024
Department enforced prerequisites: IPHY 2800 and IPHY 3700. -
IPHY 6010 - Seminar
Primary Instructor - Spring 2023
Presents special topics in integrative physiology. May be repeated up to 6 total credit hours.
Background
education and training
- Ph.D., University of Kentucky 2014
- B.S., Eastern Kentucky University 2007
International Activities
geographic focus
- Australia Country
- Brazil Country
- France Country
- Norway Country
- United Kingdom Country