A Bioengineered Hydrogel System Enables Targeted and Sustained Intramyocardial Delivery of Neuregulin, Activating the Cardiomyocyte Cell Cycle and Enhancing Ventricular Function in a Murine Model of Ischemic Cardiomyopathy
Journal Article
Overview
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Animal Diseases - Disease Models, Animal
Animals
Animals, Inbred Strains - Mice, Inbred C57BL
Animals, Newborn
Bioengineering
Biological Factors - Neuregulin-1
Biological Science Disciplines - Immunohistochemistry
Biological Science Disciplines - Immunohistochemistry
Biomedical and Dental Materials - Hydrogel, Polyethylene Glycol Dimethacrylate
Biomedical and Dental Materials - Hydrogel, Polyethylene Glycol Dimethacrylate
Cardiomyopathies
Cell Physiological Phenomena - Cell Proliferation
Cells, Cultured
Chemistry - Immunohistochemistry
Chemistry - Immunohistochemistry
Complex Mixtures - Hydrogel, Polyethylene Glycol Dimethacrylate
Diagnostic Imaging - Microscopy, Confocal
Diagnostic Techniques and Procedures - Immunohistochemistry
Diagnostic Techniques and Procedures - Immunohistochemistry
Drug Delivery Systems - Delayed-Action Preparations
Ethylene Glycols - Hydrogel, Polyethylene Glycol Dimethacrylate
Growth - Cell Proliferation
Heart - Myocardium
Heart - Myocytes, Cardiac
Heart Diseases - Myocardial Ischemia
Histology - Immunohistochemistry
Immunologic Techniques - Immunohistochemistry
Injections
Investigative Techniques - Immunohistochemistry
Investigative Techniques - Immunohistochemistry
Investigative Techniques - Microscopy, Confocal
Macromolecular Substances - Hydrogel, Polyethylene Glycol Dimethacrylate
Macromolecular Substances - Hydrogel, Polyethylene Glycol Dimethacrylate
Male
Manufactured Materials - Hydrogel, Polyethylene Glycol Dimethacrylate
Manufactured Materials - Hydrogel, Polyethylene Glycol Dimethacrylate
Mice
Mice - Mice, Inbred C57BL
Models, Animal - Disease Models, Animal
Models, Biological - Disease Models, Animal
Muscle Cells - Myocytes, Cardiac
Muscle, Striated - Myocardium
Muscle, Striated - Myocytes, Cardiac
Musculoskeletal System - Myocardium
Nerve Tissue Proteins - Neuregulin-1
Peptides - Neuregulin-1
Pharmaceutical Preparations - Delayed-Action Preparations
Pharmaceutical Preparations - Hydrogel, Polyethylene Glycol Dimethacrylate
Proteins - Neuregulin-1
Rats
Rats, Sprague-Dawley
Vascular Diseases - Myocardial Ischemia
Ventricular Function, Left
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Date in CU Experts
Full Author List
Cohen JE; Purcell BP; MacArthur JW; Mu A; Shudo Y; Patel JB; Brusalis CM; Trubelja A; Fairman AS; Edwards BB
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