Conjugation of Emtansine Onto Trastuzumab Promotes Aggregation of the Antibody-Drug Conjugate by Reducing Repulsive Electrostatic Interactions and Increasing Hydrophobic Interactions
Journal Article
Overview
publication date
- June 1, 2019
has subject area
- Biochemical Phenomena - Protein Unfolding
- Biomedical and Dental Materials - Polysorbates
- Biophysical Phenomena - Protein Unfolding
- Blood Proteins - Ado-Trastuzumab Emtansine
- Blood Proteins - Immunoconjugates
- Blood Proteins - Trastuzumab
- Drug Compounding
- Ecological and Environmental Phenomena - Temperature
- Ecological and Environmental Phenomena - Temperature
- Environment and Public Health - Temperature
- Environment, Controlled - Temperature
- Ethylene Glycols - Polysorbates
- Globulins - Ado-Trastuzumab Emtansine
- Globulins - Immunoconjugates
- Globulins - Trastuzumab
- Hydrophobic and Hydrophilic Interactions
- Immunoproteins - Ado-Trastuzumab Emtansine
- Immunoproteins - Trastuzumab
- Lactones - Ado-Trastuzumab Emtansine
- Macrocyclic Compounds - Ado-Trastuzumab Emtansine
- Macromolecular Substances - Polysorbates
- Manufactured Materials - Polysorbates
- Noxae - Immunoconjugates
- Pharmaceutical Preparations - Excipients
- Protein Aggregates
- Protein Stability
- Solubility
- Specialty Uses of Chemicals - Excipients
- Static Electricity
- Thermodynamics - Temperature
has restriction
- closed
Date in CU Experts
- February 20, 2019 9:11 AM
Full Author List
- Gandhi AV; Randolph TW; Carpenter JF
author count
- 3
citation count
- 9
published in
Other Profiles
International Standard Serial Number (ISSN)
- 0022-3549
Electronic International Standard Serial Number (EISSN)
- 1520-6017
Digital Object Identifier (DOI)
Additional Document Info
start page
- 1973
end page
- 1983
volume
- 108
issue
- 6