Large-scale oligoribonucleotide production. Journal Article uri icon



  • Growing interest in RNAs for biomedical, agricultural, and other applications has necessitated the development of methods for producing oligoribonucleotides in milligram, or larger, quantities. Recent research on in vitro transcription has focused on optimizing solution conditions and the use of immobilized templates. In the alternative area of organic chemical synthesis, significant effort has been channeled into improving coupling efficiencies and producing modified RNA analogs which retain activity but have higher stability than unmodified RNAs.

publication date

  • April 1, 1995

has restriction

  • closed

Date in CU Experts

  • September 6, 2013 11:56 AM

Full Author List

  • Davis RH

author count

  • 1

Other Profiles

International Standard Serial Number (ISSN)

  • 0958-1669

Additional Document Info

start page

  • 213

end page

  • 217


  • 6


  • 2