New observations on the gastroesophageal antireflux barrier. Journal Article uri icon



  • The use of high-frequency ultrasound transducers combined with manometry in the gastrointestinal (GI) tract has yielded important findings concerning the anatomy, physiology, and pathophysiology of the high-pressure zone of the gastroesophageal junction and the sphincteric muscles within. These transducers have made previously invisible portions of the GI tract accessible to investigation. Three distinct high-pressure zones have been identified and correlated with anatomic structures: the extrinsic sphincter (crural diaphragm) and the two components of the intrinsic sphincter (an upper LES and a lower LES [the gastric sling fiber/clasp fiber complex]). This article discusses the possible underlying pathophysiology of gastroesophageal reflux disease; the biomechanics of the gastroesophageal junction high-pressure zone; and the mechanism of action of standard surgical and newer endoscopic therapies for gastroesophageal reflux disease.

publication date

  • September 1, 2007

has subject area

has restriction

  • closed

Date in CU Experts

  • October 2, 2015 4:30 AM

Full Author List

  • Miller L; Vegesna A; Kalra A; Besetty R; Dai Q; Korimilli A; Brasseur JG

author count

  • 7

Other Profiles

International Standard Serial Number (ISSN)

  • 0889-8553

Additional Document Info

start page

  • 601

end page

  • ix


  • 36


  • 3