Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-RafV600E kinase
Journal Article
Overview
publication date
- April 15, 2014
has subject area
- Animals
- Antineoplastic Agents
- Biochemical Phenomena - Enzyme Activation
- Biochemical Phenomena - Molecular Structure
- Biological Science Disciplines - Drug Design
- Chemical Phenomena - Molecular Structure
- Chemistry - Drug Design
- Crystallography, X-Ray
- Humans
- Investigative Techniques - Drug Design
- Investigative Techniques - Xenograft Model Antitumor Assays
- Metabolism - Enzyme Activation
- Neoplasm Transplantation - Xenograft Model Antitumor Assays
- Peptides - Proto-Oncogene Proteins B-raf
- Protein Kinase Inhibitors
- Protein-Serine-Threonine Kinases - Proto-Oncogene Proteins B-raf
- Proteins - Proto-Oncogene Proteins B-raf
- Proto-Oncogene Proteins - Proto-Oncogene Proteins B-raf
- Quinazolines
- Toxicity Tests - Inhibitory Concentration 50
- Toxicological Phenomena - Inhibitory Concentration 50
- Tumor Burden
has restriction
- closed
Date in CU Experts
- March 13, 2015 11:09 AM
Full Author List
- Wenglowsky S; Ren L; Grina J; Hansen JD; Laird ER; Moreno D; Dinkel V; Gloor SL; Hastings G; Rana S
author count
- 17
citation count
- 19
published in
Other Profiles
International Standard Serial Number (ISSN)
- 0960-894X
Electronic International Standard Serial Number (EISSN)
- 1464-3405
Digital Object Identifier (DOI)
Additional Document Info
start page
- 1923
end page
- 1927
volume
- 24
issue
- 8