Enzymes - RNA, Catalytic PubMed MeSh Term

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subject area of

• In Crystallo Selection to Establish New RNA Crystal Contacts  Journal Article
• A CONSERVED BASE PAIR WITHIN HELIX-P4 OF THE TETRAHYMENA RIBOZYME HELPS TO FORM THE TERTIARY STRUCTURE REQUIRED FOR SELF-SPLICING  Journal Article
• A HAMMERHEAD RIBOZYME ALLOWS SYNTHESIS OF A NEW FORM OF THE TETRAHYMENA RIBOZYME HOMOGENEOUS IN LENGTH WITH A 3' END BLOCKED FOR TRANSESTERIFICATION  Journal Article
• A KINETIC AND THERMODYNAMIC FRAMEWORK FOR THE HAMMERHEAD RIBOZYME REACTION  Journal Article
• A POSITIVE ENTROPY CHANGE FOR GUANOSINE BINDING AND FOR THE CHEMICAL STEP IN THE TETRAHYMENA RIBOZYME REACTION  Journal Article
• A SELF-SPLICING GROUP-I INTRON IN THE NUCLEAR PRE-RIBOSOMAL-RNA OF THE GREEN-ALGA, ANKISTRODESMUS-STIPITATUS  Journal Article
• A SMALL CATALYTIC OLIGORIBONUCLEOTIDE  Journal Article
• A SMALL METALLORIBOZYME WITH A 2-STEP MECHANISM  Journal Article
• A TERTIARY INTERACTION IN THE TETRAHYMENA INTRON CONTRIBUTES TO SELECTION OF THE 5' SPLICE-SITE  Journal Article
• A TETRAHYMENA INTRON NUCLEOTIDE CONNECTED TO THE GTP ARGININE SITE  Journal Article
• A conformational change in the catalytic core of the hammerhead ribozyme upon cleavage of an RNA substrate  Journal Article
• A covalent crosslink converts the hammerhead ribozyme from a ribonuclease to an RNA ligase  Journal Article
• A kinetic and thermodynamic analysis of cleavage site mutations in the hammerhead ribozyme  Journal Article
• A natural ribozyme with 3 ',5 ' RNA ligase activity  Journal Article
• A preorganized active site in the crystal structure of the Tetrahymena ribozyme  Journal Article
• A re-investigation of the thio effect at the hammerhead cleavage site  Journal Article
• A second catalytic metal ion in a group I ribozyme  Journal Article
• A universal mode of helix packing in RNA  Journal Article
• ALTERATION OF SUBSTRATE-SPECIFICITY FOR THE ENDORIBONUCLEOLYTIC CLEAVAGE OF RNA BY THE TETRAHYMENA RIBOZYME  Journal Article
• AMINOACYL ESTERASE-ACTIVITY OF THE TETRAHYMENA RIBOZYME  Journal Article
• AN IMPORTANT RNA TERTIARY INTERACTION OF GROUP-I AND GROUP-II INTRONS IS IMPLICATED IN GRAM-POSITIVE RNASE-P RNAS  Journal Article
• AN INDEPENDENTLY FOLDING DOMAIN OF RNA TERTIARY STRUCTURE WITHIN THE TETRAHYMENA RIBOZYME  Journal Article
• AN ULTRAVIOLET-INDUCIBLE ADENOSINE ADENOSINE CROSS-LINK REFLECTS THE CATALYTIC STRUCTURE OF THE TETRAHYMENA RIBOZYME  Journal Article
• ANALYSIS OF THE STRUCTURE OF TETRAHYMENA NUCLEAR RNAS IN-VIVO - TELOMERASE RNA, THE SELF-SPLICING RIBOSOMAL-RNA INTRON, AND U2 SNRNA  Journal Article
• Active site dynamics in the lead-dependent ribozyme  Journal Article
• An RNA internal loop acts as a hinge to facilitate ribozyme folding and catalysis  Journal Article
• An early transition state for folding of the P4-P6 RNA domain  Journal Article
• Assembly of a ribonucleoprotein catalyst by tertiary structure capture  Journal Article
• Atomic level architecture of group I introns revealed  Journal Article
• Base and sugar requirements for RNA cleavage of essential nucleoside residues in internal loop B of the hairpin ribozyme: Implications for secondary structure  Journal Article
• CATALYSIS OF RNA CLEAVAGE BY A RIBOZYME DERIVED FROM THE GROUP-I INTRON OF ANABAENA PRE-TRNA(LEU)  Journal Article
• CATALYSIS OF RNA CLEAVAGE BY THE TETRAHYMENA-THERMOPHILA RIBOZYME .1. KINETIC DESCRIPTION OF THE REACTION OF AN RNA SUBSTRATE COMPLEMENTARY TO THE ACTIVE-SITE  Journal Article
• CATALYSIS OF RNA CLEAVAGE BY THE TETRAHYMENA-THERMOPHILA RIBOZYME .2. KINETIC DESCRIPTION OF THE REACTION OF AN RNA SUBSTRATE THAT FORMS A MISMATCH AT THE ACTIVE-SITE  Journal Article
• CATALYTIC RNA - STRUCTURE AND MECHANISM  Journal Article
• CHARACTERIZATION OF DEOXY-CONTAINING AND RIBO-CONTAINING OLIGONUCLEOTIDE SUBSTRATES IN THE HAMMERHEAD SELF-CLEAVAGE REACTION  Journal Article
• CIRCULARLY PERMUTED TRANSFER-RNAS AS SPECIFIC PHOTOAFFINITY PROBES OF RIBONUCLEASE-P RNA STRUCTURE  Journal Article
• COAXIALLY STACKED RNA HELICES IN THE CATALYTIC CENTER OF THE TETRAHYMENA RIBOZYME  Journal Article
• CONSERVED SEQUENCES AND STRUCTURES OF GROUP-I INTRONS - BUILDING AN ACTIVE-SITE FOR RNA CATALYSIS - A REVIEW  Journal Article
• CONTRIBUTIONS OF 2'-HYDROXYL GROUPS OF THE RNA SUBSTRATE TO BINDING AND CATALYSIS BY THE TETRAHYMENA RIBOZYME - AN ENERGETIC PICTURE OF AN ACTIVE-SITE COMPOSED OF RNA  Journal Article
• Catalytic diversity of extended hammerhead ribozymes.  Journal Article
• Circular substrates of the hammerhead ribozyme shift the internal equilibrium further toward cleavage  Journal Article
• Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme  Journal Article
• Comparison of the hammerhead cleavage reactions stimulated by monovalent and divalent cations  Journal Article
• Conserved thermochemistry of guanosine nucleophile binding for structurally distinct group I ribozymes  Journal Article
• Correlation of the guanosine exchangeable and nonexchangeable base protons in C-13-(IN)-N-15-labeled RNA with an HNC-TOCSY-CH experiment  Journal Article
• Crawling Out of the RNA World  Journal Article
• Cryoenzymology of the hammerhead ribozyme  Journal Article
• Crystal structure of a bacterial ribonuclease P RNA  Journal Article
• Crystal structure of a group I ribozyme domain: Principles of RNA packing  Journal Article
• Crystals by design: A strategy for crystallization of a ribozyme derived from the Tetrahymena group I intron  Journal Article
• DEFINING THE INSIDE AND OUTSIDE OF A CATALYTIC RNA MOLECULE  Journal Article
• DIRECT MEASUREMENT OF OLIGONUCLEOTIDE SUBSTRATE BINDING TO WILD-TYPE AND MUTANT RIBOZYMES FROM TETRAHYMENA  Journal Article
• DIVALENT METAL-IONS AND THE INTERNAL EQUILIBRIUM OF THE HAMMERHEAD RIBOZYME  Journal Article
• DIVERSITY OF OLIGONUCLEOTIDE FUNCTIONS  Journal Article
• DNA CLEAVAGE CATALYZED BY THE RIBOZYME FROM TETRAHYMENA  Journal Article
• EVIDENCE FOR THE ROLE OF SOLVATED METAL HYDROXIDE IN THE HAMMERHEAD CLEAVAGE MECHANISM  Journal Article
• Effects of divalent metal ions on individual steps of the Tetrahymena ribozyme reaction  Journal Article
• Efficient ligation of the Schistosoma hammerhead ribozyme  Journal Article
• Energetics and cooperativity of tertiary hydrogen bonds in RNA structure  Journal Article
• Enhanced product stability in the hammerhead ribozyme.  Journal Article
• Evolution of Biological Catalysis: Ribozyme to RNP Enzyme  Journal Article
• Evolution of Tetrahymena ribozyme mutants with increased structural stability  Journal Article
• Exocyclic amine of the conserved G center dot U pair at the cleavage site of the Tetrahymena ribozyme contributes to 5'-splice site selection and transition state stabilization  Journal Article
• Expression, purification, crystallization and preliminary diffraction analysis of RNase P protein from Thermotoga maritima  Journal Article
• FOLDING OF GROUP-I INTRONS FROM BACTERIOPHAGE-T4 INVOLVES INTERNALIZATION OF THE CATALYTIC CORE  Journal Article
• Fast cleavage kinetics of a natural hammerhead ribozyme  Journal Article
• Functional groups on the cleavage site pyrimidine nucleotide are required for stabilization of the hammerhead transition state  Journal Article
• GUANOSINE BINDING TO THE TETRAHYMENA RIBOZYME - THERMODYNAMIC COUPLING WITH OLIGONUCLEOTIDE BINDING  Journal Article
• HAMMERHEAD .2.  Journal Article
• Hammerhead cleavage of the phosphorodithioate linkage  Journal Article
• Hammerhead redux: does the new structure fit the old biochemical data?  Journal Article
• Hammerhead ribozyme kinetics  Journal Article
• Hammerhead ribozymes with a faster cleavage rate  Journal Article
• Hammerhead: Part 2.  Journal Article
• Hammerheads derived from sTRSV show enhanced cleavage and ligation rate constants.  Journal Article
• High-performance liquid chromatography purification of homogenous-length RNA produced by trans cleavage with a hammerhead ribozyme  Journal Article
• High-resolution structure of RNase P protein from Thermotoga maritima  Journal Article
• IDENTIFICATION OF RIBOZYMES WITHIN A RIBOZYME LIBRARY THAT EFFICIENTLY CLEAVE A LONG SUBSTRATE RNA  Journal Article
• IMPROVED MEASUREMENT OF C-13, P-31 J-COUPLING-CONSTANTS IN ISOTOPICALLY LABELED RNA  Journal Article
• INHIBITION OF THE HAMMERHEAD RIBOZYME BY NEOMYCIN  Journal Article
• Identification and characterization of a novel high affinity metal-binding site in the hammerhead ribozyme  Journal Article
• Improved distance analysis in RNA using network-editing techniques for overcoming errors due to spin diffusion  Journal Article
• Improved native affinity purification of RNA  Journal Article
• In vitro selection of a novel catalytic RNA: Characterization of a sulfur alkylation reaction and interaction with a small peptide  Journal Article
• In vitro selection of self-cleaving RNAs with a low pH optimum  Journal Article
• In vitro selection of the Naegleria GIR1 ribozyme identifies three base changes that dramatically improve activity  Journal Article
• Inhibition of the hammerhead ribozyme cleavage reaction by site-specific binding of Tb(III)  Journal Article
• Internal equilibrium of the hammerhead ribozyme is altered by the length of certain covalent cross-links  Journal Article
• Involvement of a specific metal ion in the transition of the hammerhead ribozyme to its catalytic conformation  Journal Article
• Joining the two domains of a group I ribozyme to form the catalytic core  Journal Article
• KINETIC CHARACTERIZATION OF INTRAMOLECULAR AND INTERMOLECULAR HAMMERHEAD RNAS WITH STEM-II DELETIONS  Journal Article
• KINETICS OF INTERMOLECULAR CLEAVAGE BY HAMMERHEAD RIBOZYMES  Journal Article
• Kinetic and secondary structure analysis of Naegleria andersoni GIR1, a group I ribozyme whose putative biological function is site-specific hydrolysis  Journal Article
• Kinetic characterization of two I/II format hammerhead ribozymes  Journal Article
• Kinetic pathway for folding of the Tetrahymena ribozyme revealed by three UV-inducible crosslinks  Journal Article
• Linking RNA biology to lncRNAs  Journal Article
• Local RNA structural changes induced by crystallization are revealed by SHAPE  Journal Article
• METAL-ION CATALYSIS IN THE TETRAHYMENA RIBOZYME REACTION  Journal Article
• METAL-ION REQUIREMENTS FOR SEQUENCE-SPECIFIC ENDORIBONUCLEASE ACTIVITY OF THE TETRAHYMENA RIBOZYME  Journal Article
• MINOR-GROOVE RECOGNITION OF THE CONSERVED G-CENTER-DOT-U PAIR AT THE TETRAHYMENA RIBOZYME REACTION SITE  Journal Article
• MOVEMENT OF THE GUIDE SEQUENCE DURING RNA CATALYSIS BY A GROUP-I RIBOZYME  Journal Article
• MUTATIONS AT THE GUANOSINE-BINDING SITE OF THE TETRAHYMENA RIBOZYME ALSO AFFECT SITE-SPECIFIC HYDROLYSIS  Journal Article
• MUTATIONS IN A NONCONSERVED SEQUENCE OF THE TETRAHYMENA RIBOZYME INCREASE ACTIVITY AND SPECIFICITY  Journal Article
• Measurement of carbon-phosphorus J coupling constants in RNA using spin-echo difference constant-time HCCH-COSY  Journal Article
• Metal ion specificities for folding and cleavage activity in the Schistosoma hammerhead ribozyme  Journal Article
• Modified nucleotidesmay have enhanced early RNA catalysis  Journal Article
• Monitoring post-translational modification of proteins with allosteric ribozymes  Journal Article
• Multiple folding pathways for the P4-P6 RNA domain  Journal Article
• Mutagenesis and comparative sequence analysis of a base triple joining the two domains of group I ribozymes  Journal Article
• Mutations in the Tetrahymena ribozyme internal guide sequence: Effects on docking of the P1 helix into the catalytic core and correlation with catalytic activity  Journal Article
• NEOMYCIN INHIBITION OF THE HAMMERHEAD RIBOZYME INVOLVES IONIC INTERACTIONS  Journal Article
• NMR solution structure of the lead-dependent ribozyme: Evidence for dynamics in RNA catalysis  Journal Article
• NUCLEAR-MAGNETIC-RESONANCE STUDIES OF THE HAMMERHEAD RIBOZYME DOMAIN - SECONDARY STRUCTURE FORMATION AND MAGNESIUM-ION DEPENDENCE  Journal Article
• NUMBERING SYSTEM FOR THE HAMMERHEAD  Journal Article
• Natural and artificial RNAs occupy the same restricted region of sequence space  Journal Article
• On the occasion of the 25(th) anniversary of the discovery of catalytic RNA  Journal Article
• Order, dynamics and metal-binding in the lead-dependent ribozyme  Journal Article
• Peptide bond formation by in vitro selected ribozymes  Journal Article
• Peptidyl-transferase ribozymes: trans reactions, structural characterization and ribosomal RNA-like features  Journal Article
• Photoaffinity cross-linking and RNA structure analysis  Journal Article
• Phylogenetic-comparative analysis of the eukaryal ribonuclease P RNA  Journal Article
• Probing the binding of Tb(III) and Eu(III) to the hammerhead ribozyme using luminescence spectroscopy  Journal Article
• Protein activation of a ribozyme: the role of bacterial RNase P protein  Journal Article
• RELATIVE ORIENTATION OF RNA HELICES IN A GROUP-I RIBOZYME DETERMINED BY HELIX EXTENSION ELECTRON-MICROSCOPY  Journal Article
• REPLACEMENT OF THE CONSERVED G-CENTER-DOT-U WITH A G-C PAIR AT THE CLEAVAGE SITE OF THE TETRAHYMENA RIBOZYME DECREASES BINDING, REACTIVITY, AND FIDELITY  Journal Article
• RIBOZYME RECOGNITION OF RNA BY TERTIARY INTERACTIONS WITH SPECIFIC RIBOSE 2'-OH GROUPS  Journal Article
• RIBOZYME REVEALED  Journal Article
• RIBOZYME-CATALYZED AND NONENZYMATIC REACTIONS OF PHOSPHATE DIESTERS - RATE EFFECTS UPON SUBSTITUTION OF SULFUR FOR A NONBRIDGING PHOSPHORYL OXYGEN ATOM  Journal Article
• RIBOZYME-MEDIATED REPAIR OF DEFECTIVE MESSENGER-RNA BY TARGETED TRANSSPLICING  Journal Article
• RIBOZYMES - HAMMERHEAD NAILED DOWN  Journal Article
• RNA - FISHING FOR FRESH CATALYSTS  Journal Article
• RNA AS AN ENZYME  Journal Article
• RNA AS AN RNA-POLYMERASE - NET ELONGATION OF AN RNA PRIMER CATALYZED BY THE TETRAHYMENA RIBOZYME  Journal Article
• RNA CATALYSIS BY A GROUP-I RIBOZYME - DEVELOPING A MODEL FOR TRANSITION-STATE STABILIZATION  Journal Article
• RNA CHEMISTRY - RIBOZYME SELF-REPLICATION  Journal Article
• RNA SUBSTRATE BINDING-SITE IN THE CATALYTIC CORE OF THE TETRAHYMENA RIBOZYME  Journal Article
• RNA as the catalyst for drug screening - Reporter ribozymes that allow monitoring of protein-nucleic acid and protein-protein interactions facilitate rapid identification of inhibitors for use in drug discovery.  Journal Article
• RNA finds a simpler way  Journal Article
• RNA tertiary folding monitored by fluorescence of covalently attached pyrene  Journal Article
• RNA tertiary structure mediation by adenosine platforms  Journal Article
• RNA-Puzzles Round III: 3D RNA structure prediction of five riboswitches and one ribozyme  Journal Article
• RNA-Puzzles Round IV: 3D structure predictions of four ribozymes and two aptamers  Journal Article
• ROLE OF DIVALENT METAL-IONS IN THE HAMMERHEAD RNA CLEAVAGE REACTION  Journal Article
• Rapid and Simple Ribozymic Aminoacylation Using Three Conserved Nucleotides  Journal Article
• Recurrent RNA motifs as scaffolds for genetically encodable small-molecule biosensors  Journal Article
• Riboswitches: still a lot of undiscovered country  Journal Article
• Ribozymes, the first 20 years  Journal Article
• SELF-ASSEMBLY OF A GROUP-I INTRON ACTIVE-SITE FROM ITS COMPONENT TERTIARY STRUCTURAL DOMAINS  Journal Article
• SELF-CLEAVING CATALYTIC RNA  Journal Article
• SELF-SPLICING AND ENZYMATIC CLEAVAGE OF RNA BY A GROUP-I INTERVENING SEQUENCE  Journal Article
• SELF-SPLICING OF THE GROUP-I INTRON FROM ANABAENA PRE-TRANSFER-RNA - REQUIREMENT FOR BASE-PAIRING OF THE EXONS IN THE ANTICODON STEM  Journal Article
• SELF-SPLICING RNA AND AN RNA ENZYME IN TETRAHYMENA  Journal Article
• SEQUENCE REQUIREMENTS OF THE HAMMERHEAD RNA SELF-CLEAVAGE REACTION  Journal Article
• SEQUENCE-DEPENDENT STRUCTURAL VARIATIONS OF HAMMERHEAD RNA ENZYMES  Journal Article
• SEQUENCE-SPECIFIC ENDORIBONUCLEASE ACTIVITY OF THE TETRAHYMENA RIBOZYME - ENHANCED CLEAVAGE OF CERTAIN OLIGONUCLEOTIDE SUBSTRATES THAT FORM MISMATCHED RIBOZYME SUBSTRATE COMPLEXES  Journal Article
• SPECIFICITY FOR 3',5'-LINKED SUBSTRATES IN RNA-CATALYZED RNA POLYMERIZATION  Journal Article
• STEREOCHEMISTRY OF RNA CLEAVAGE BY THE TETRAHYMENA RIBOZYME AND EVIDENCE THAT THE CHEMICAL STEP IS NOT RATE-LIMITING  Journal Article
• STUDIES ON THE HAMMERHEAD RNA SELF-CLEAVING DOMAIN  Journal Article
• SUBSTRATE SEQUENCE EFFECTS ON HAMMERHEAD RNA CATALYTIC EFFICIENCY  Journal Article
• Self-splicing of group I introns.  Journal Article
• Self-splicing of the Tetrahymena intron from mRNA in mammalian cells  Journal Article
• Solution structure of RNase P RNA  Journal Article
• Specificity of hammerhead ribozyme cleavage  Journal Article
• Steric interference modification of the hammerhead ribozyme  Journal Article
• Structural basis of the enhanced stability of a mutant ribozyme domain and a detailed view of RNA-solvent interactions  Journal Article
• Structural studies of catalytic RNAs by heteronuclear multi-dimensional NMR.  Journal Article
• Structural variation induced by different nucleotides at the cleavage site of the hammerhead ribozyme  Journal Article
• Structure of the Tetrahymena ribozyme:: Base triple sandwich and metal ion at the active site  Journal Article
• TERTIARY INTERACTIONS WITH THE INTERNAL GUIDE SEQUENCE MEDIATE DOCKING OF THE P1 HELIX INTO THE CATALYTIC CORE OF THE TETRAHYMENA RIBOZYME  Journal Article
• TERTIARY STRUCTURE AROUND THE GUANOSINE-BINDING SITE OF THE TETRAHYMENA RIBOZYME  Journal Article
• TETHERING RIBOZYMES TO A RETROVIRAL PACKAGING SIGNAL FOR DESTRUCTION OF VIRAL-RNA  Journal Article
• THE EFFECT OF BASE MISMATCHES IN THE SUBSTRATE RECOGNITION HELICES OF HAMMERHEAD RIBOZYMES ON BINDING AND CATALYSIS  Journal Article
• THE EFFICIENCY AND VERSATILITY OF CATALYTIC RNA - IMPLICATIONS FOR AN RNA WORLD  Journal Article
• THE IMPORTANCE OF BEING RIBOSE AT THE CLEAVAGE SITE IN THE TETRAHYMENA RIBOZYME REACTION  Journal Article
• THE INTERNAL EQUILIBRIUM OF THE HAMMERHEAD RIBOZYME REACTION  Journal Article
• THE SELF-SPLICING RNA OF TETRAHYMENA IS TRAPPED IN A LESS ACTIVE CONFORMATION BY GEL PURIFICATION  Journal Article
• THE TETRAHYMENA RIBOZYME ACTS LIKE AN RNA RESTRICTION ENDONUCLEASE  Journal Article
• THIOPHOSPHATE INTERFERENCE EXPERIMENTS LOCATE PHOSPHATES IMPORTANT FOR THE HAMMERHEAD RNA SELF-CLEAVAGE REACTION  Journal Article
• TRANSLOCATION OF AN RNA DUPLEX ON A RIBOZYME  Journal Article
• The Cech Symposium: A celebration of 25 years of ribozymes, 10 years of TERT, and 60 years of Tom  Journal Article
• The Noncoding RNA Revolution-Trashing Old Rules to Forge New Ones  Journal Article
• The Tetrahymena ribozyme cleaves a 5 '-methylene phosphonate monoester similar to 10(2)-fold faster than a normal phosphate diester: Implications for enzyme catalysis of phosphoryl transfer reactions  Journal Article
• The chemical repertoire of natural ribozymes  Journal Article
• The global conformation of the hammerhead ribozyme determined using residual dipolar couplings  Journal Article
• The hammerhead ribozyme  Conference Proceeding
• The intervening sequence RNA of Tetrahymena is an enzyme. 1986.  Journal Article
• The parallel universe of RNA folding  Journal Article
• The structure-function dilemma of the hammerhead ribozyme.  Journal Article
• Thermodynamic dissection of the substrate-ribozyme interaction in the hammerhead ribozyme  Journal Article
• Thermodynamics and kinetics for base-pair opening in the P1 duplex of the Tetrahymena group I ribozyme  Journal Article
• Toward predicting self-splicing and protein-facilitated splicing of group I introns  Journal Article
• Two major tertiary folding transitions of the Tetrahymena catalytic RNA.  Journal Article
• Use of intrinsic binding energy for catalysis by an RNA enzyme  Journal Article
• VISUALIZATION OF A TERTIARY STRUCTURAL DOMAIN OF THE TETRAHYMENA GROUP-I INTRON BY ELECTRON-MICROSCOPY  Journal Article
• VISUALIZING THE HIGHER-ORDER FOLDING OF A CATALYTIC RNA MOLECULE  Journal Article
• When to believe what you see.  Journal Article
• X-ray crystallography of large RNAs: Heavy-atom derivatives by RNA engineering  Journal Article

broader concept

• Enzymes  PubMed MeSh Term

narrower concept

• Enzymes - Ribonuclease P  PubMed MeSh Term