Our research group in University of Colorado Boulder centers on cutting-edge micro/nano systems for various applications in biomedicine, particularly in cell manipulation, cell membrane disruption and repair, intracellular delivery and subcellular delivery. Our platform will benefit various fields in fundamental cell studies, biochemistry, medical diagnosis, and therapeutics. We aim to develop cutting-edge tools and technologies 1) for intracellular delivery of hard-to-transfer cells such as immune cells, and subcellular drug delivery, such as organelles; 2) investigate cell membrane disruption and recovery under varies of stimulation; 3) explore cell mechanics and mechanical biomarkers; 4) for protein analysis; and 5) for human healthcare, point-of-care disease diagnostics, and medical therapeutics.
keywords
microfluidics, BioMEMS, intracellular delivery, cell membrane disruption and repair, cell mechanics, drug delivery for immunotherapy and gene editing, electroporation, sonoporation, micro/nano system for intracellular delivery and subcellular delivery, micro/nano system for cell manipulation, cell sorting, cell separation, cell trapping
Surface acoustic wave microfluidics.
Lab on a Chip: miniaturisation for chemistry, physics, biology, materials science and bioengineering.
3626-3649.
2013
MCEN 3021 - Fluid Mechanics
Primary Instructor
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Spring 2019 / Spring 2022
Examines fundamentals of fluid flow with application to engineering problems. Topics covered include fluid statics and kinematics, Bernoulli equations, laminar and turbulent viscous boundary layers, laminar and turbulent pipe flow, and conservation equations for mass, momentum and energy. Same as CHEN 3200 and CVEN 3313.
MCEN 4085 - Mechanical Engineering Senior Design Project 2
Primary Instructor
-
Spring 2020
Second part of a two-course capstone design experience in mechanical engineering. Includes refinement of prototype, design optimization, fabrication, testing, and evaluation. Students orally present the final design and prepare a written report and operation manual for the product. GEEN-BS and GEEN-BSEPL students are not required to complete MCEN 4026.
MCEN 4171 - Biofluids on the Micro Scale
Primary Instructor
-
Spring 2024
Introduces fundamental physical concepts and basic mechanisms of biological fluids in microscale. Elaborates on the application of fluid mechanics principles to major biological systems, including human organ systems and animal locomotion in microscale. Covers physiologically relevant fluid flow phenomena on the cellular level and the underlying physical mechanisms from an engineering perspective. Related state-of-art technologies such as organ-on-a-chip and micro/nano fabrication will be emphasized. Will enhance your understanding of organ-on-a-chip technologies and their broad applications. Same as BMEN 4171 and MCEN 5171 and BMEN 5171.
MCEN 4228 - Special Topics in Mechanical Engineering
Primary Instructor
-
Spring 2018 / Fall 2018 / Fall 2019 / Spring 2020 / Fall 2020 / Fall 2021 / Fall 2022
Subject matter to be selected from topics of current interest. May be repeated up to 15 credit hours. Same as MCEN 5228.
MCEN 5171 - Biofluids on the Micro Scale
Primary Instructor
-
Spring 2024
Introduces fundamental physical concepts and basic mechanisms of biological fluids in microscale. Elaborates on the application of fluid mechanics principles to major biological systems, including human organ systems and animal locomotion in microscale. Covers physiologically relevant fluid flow phenomena on the cellular level and the underlying physical mechanisms from an engineering perspective. Related state-of-art technologies such as organ-on-a-chip and micro/nano fabrication will be emphasized. Will enhance your understanding of organ-on-a-chip technologies and their broad applications. Same as BMEN 5171 and MCEN 4171 and BMEN 4171.
MCEN 5228 - Special Topics in Mechanical Engineering
Primary Instructor
-
Spring 2018 / Fall 2018 / Spring 2020 / Fall 2020 / Fall 2021 / Fall 2022
Subject matter to be selected from topics of current interest. May be repeated up to 30 credit hours.
