research overview
- Dr. Allen's research is centered around an integrative understanding of the factors influencing physical activity levels and how physical activity levels influence health and fitness outcomes.
- Contact Info
Allen, David Lehigh
Positions
- Associate Teaching Professor, Psychology and Neuroscience
Research Areas
Research
keywords
- cellular and molecular mechanisms underlying skeletal muscle plasticity in response to activity, injury, obesity, and stress; effects of technology, drug use, and injury on physical activity levels
Publications
selected publications
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conference proceeding
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Increased Extracellular Matrix Degradation Following Eccentric Versus Concentric Muscle Actions in Humans.
Medicine and Science in Sports and Exercise.
899-899.
2016
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Inactivation of the Matrix Metalloproteinase-9 (MMP-9) Gene Decreased Cross Sectional Area of Mouse Hindlimb Skeletal Muscle Fibers.
Medicine and Science in Sports and Exercise.
377-377.
2010
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Adaptations in skeletal muscle disuse or decreased-use atrophy.
American Journal of Physical Medicine and Rehabilitation.
S127-S147.
2001
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THE EFFECTS OF VOLUNTARY WHIRL RUNNING IN MYHC-IIB NULL MICE.
Medicine and Science in Sports and Exercise.
S268-S268.
2001
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Increased Extracellular Matrix Degradation Following Eccentric Versus Concentric Muscle Actions in Humans.
Medicine and Science in Sports and Exercise.
899-899.
2016
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journal article
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Guidelines for animal exercise and training protocols for cardiovascular studies.
American Journal of Physiology: Heart and Circulatory Physiology.
H1100-H1138.
2020
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REVISITING THE FORCE-JOINT ANGLE RELATIONSHIP AFTER ECCENTRIC EXERCISE.
Journal of Strength and Conditioning Research.
3284-3291.
2015
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Plasma Matrix Metalloproteinase-9 Response to Downhill Running in Humans.
International Journal of Sports Medicine.
363-370.
2014
- Functional and Sensorimotor Adaptations to Stress and Injury in Mice. Journal of General Internal Medicine. 370-370. 2012
- Plasma Matrix Metalloproteinase-9 is Unchanged Following Downhill Running in Concentrically-trained Individuals. Journal of General Internal Medicine. 372-372. 2012
- Aging is Associated with Increased Skeletal Muscle Type IV Collagen Content and Decreased MMP-2 Expression in Mice. Medicine and Science in Sports and Exercise. 690-691. 2012
- Plasma Matrix Metalloproteinase-9 (MMP-9) is Increased Following Downhill Running in Sedentary Individuals. Medicine and Science in Sports and Exercise. 695-695. 2012
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Expression and Function of Myostatin in Obesity, Diabetes, and Exercise Adaptation.
Medicine and Science in Sports and Exercise.
1828-1835.
2011
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Plasma matrix metalloproteinase-9 response to eccentric exercise of the elbow flexors.
European Journal of Applied Physiology.
1795-1805.
2011
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Functional and Sensorimotor Adaptations to Stress and Injury in Mice.
Medicine and Science in Sports and Exercise.
370-370.
2011
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Plasma Matrix Metalloproteinase-9 is Unchanged Following Downhill Running in Concentrically-trained Individuals.
Medicine and Science in Sports and Exercise.
372-372.
2011
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IIb or not IIb? Regulation of myosin heavy chain gene expression in mice and men.
Skeletal Muscle.
2011
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Matrix Metalloproteinase-9 Deficiency Results in Decreased Fiber Cross-Sectional Area and Alters Fiber Type Distribution in Mouse Hindlimb Skeletal Muscle.
Cells, Tissues, Organs: in vivo, in vitro.
510-520.
2011
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Posttranscriptional mechanisms involving microRNA-27a and b contribute to fast-specific and glucocorticoid-mediated myostatin expression in skeletal muscle.
American Journal of Physiology: Cell Physiology.
C124-C137.
2011
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CCAAT/enhancer binding protein-δ expression is increased in fast skeletal muscle by food deprivation and regulates myostatin transcription in vitro.
American Journal of Physiology: Regulatory, Integrative and Comparative Physiology.
R1592-R1601.
2010
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Skeletal muscle expression of bone morphogenetic protein-1 and tolloid-like-1 extracellular proteases in different fiber types and in response to unloading, food deprivation and differentiation (vol 60, pg 343, 2010).
Journal of Physiological Sciences.
447-447.
2010
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Acute daily psychological stress causes increased atrophic gene expression and myostatin-dependent muscle atrophy.
American Journal of Physiology: Regulatory, Integrative and Comparative Physiology.
R889-R898.
2010
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Myostatin expression is increased by food deprivation in a muscle-specific manner and contributes to muscle atrophy during prolonged food deprivation in mice.
Journal of Applied Physiology.
692-701.
2010
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Skeletal muscle expression of bone morphogenetic protein-1 and tolloid-like-1 extracellular proteases in different fiber types and in response to unloading, food deprivation and differentiation.
Journal of Physiological Sciences.
343-352.
2010
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Calcineurin activates interleukin-6 transcription in mouse skeletal muscle in vivo and in C2C12 myotubes in vitro.
American Journal of Physiology: Regulatory, Integrative and Comparative Physiology.
R198-R210.
2010
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Effects of spaceflight on murine skeletal muscle gene expression.
Journal of Applied Physiology.
582-595.
2009
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Comparative functional analysis of the cow and mouse myostatin genes reveals novel regulatory elements in their upstream promoter regions.
Comparative Biochemistry and Physiology B: Biochemistry and Molecular Biology.
432-439.
2008
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Making sense (and antisense) of myosin heavy chain gene expression. Comments on "Intergenic bidirectional promoter and cooperative regulation of the IIx and IIb MHC genes in fast skeletal muscle" by Rinaldi et al..
American Journal of Physiology: Regulatory, Integrative and Comparative Physiology.
R206-R207.
2008
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Expression of Components of the Myostatin Signaling Pathway in Fasting Mouse Skeletal Muscle and Adipose.
Medicine and Science in Sports and Exercise.
S33-S33.
2008
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Leptin and Obesity Alter Expression of Myostatin and its Receptor ActRIIb in Mouse Skeletal Muscle.
Medicine and Science in Sports and Exercise.
S193-S193.
2008
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Myostatin, activin receptor IIb, and follistatin-like-3 gene expression are altered in adipose tissue and skeletal muscle of obese mice.
American Journal of Physiology: Endocrinology and Metabolism.
E918-E927.
2008
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Transcriptional Regulation of Interleukin-6 Expression in Mouse Skeletal Muscle in Vivo and in Myotubes in Vitro.
Medicine and Science in Sports and Exercise.
S163-S163.
2008
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CHRNA4 and tobacco dependence - From gene regulation to treatment outcome.
Archives of General Psychiatry.
1078-1086.
2007
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A transdisciplinary model integrating genetic, physiological, and psychological correlates of voluntary exercise.
Health Psychology.
30-39.
2007
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Regulation of myostatin expression and myoblast differentiation by FoxO and SMAD transcription factors.
American Journal of Physiology: Cell Physiology.
C188-C199.
2007
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MyoD, Myf5, and the calcineurin pathway activate the developmental myosin heavy chain genes.
Developmental Biology.
541-553.
2006
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Regulation of Myostatin Expression and Myoblast Differentiation by FoxO and SMAD Transcription Factors.
Medicine and Science in Sports and Exercise.
S62-S63.
2006
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Loaded wheel running and muscle adaptation in the mouse.
American Journal of Physiology: Heart and Circulatory Physiology.
H455-H465.
2005
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Myocyte enhancer factor-2 and serum response factor binding elements regulate fast myosin heavy chain transcription in vivo.
Journal of Biological Chemistry.
17126-17134.
2005
- Muscle- and fiber-specific regulation of the myosin heavy chain genes. The FASEB Journal. A117-A117. 2005
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Skeletal muscle adaptations to microgravity exposure in the mouse.
Journal of Applied Physiology.
2462-2470.
2003
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Loss of desmin leads to impaired voluntary wheel running and treadmill exercise performance.
Journal of Applied Physiology.
1617-1622.
2003
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Transcriptional regulation of IGF-I expression in skeletal muscle.
American Journal of Physiology: Cell Physiology.
C831-C839.
2003
- The impact of voluntary resistance training on murine skeletal and cardiac hypertrophy. Biophysical Journal. 20A-20A. 2003
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Intracellular calcium and myosin isoform transitions - Calcineurin and calcium-calmodulin kinase pathways regulate preferential activation of the iia myosin heavy chain promoter.
Journal of Biological Chemistry.
45323-45330.
2002
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Molecular and genetic approaches to studying exercise performance and adaptation.
Exercise and Sport Sciences Reviews.
99-105.
2002
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Genetic variability in forced and voluntary endurance exercise performance in seven inbred mouse strains.
Journal of Applied Physiology.
2245-2255.
2002
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Skeletal muscle adaptations in response to voluntary wheel running in myosin heavy chain null mice.
Journal of Applied Physiology.
313-322.
2002
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Different pathways regulate expression of the skeletal myosin heavy chain genes.
Journal of Biological Chemistry.
43524-43533.
2001
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Cardiac and skeletal muscle adaptations to voluntary wheel running in the mouse.
Journal of Applied Physiology.
1900-1908.
2001
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Mutation of the IIB myosin heavy chain gene results in muscle fiber loss and compensatory hypertrophy.
American Journal of Physiology: Cell Physiology.
C637-C645.
2001
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Postnatal myosin heavy chain isoform expression in normal mice and mice null for IIb or IId myosin heavy chains.
Developmental Biology.
383-395.
2001
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Inactivation of myosin heavy chain genes in the mouse: Diverse and unexpected phenotypes.
Microscopy Research and Technique.
492-499.
2000
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Spatial and temporal changes in myosin heavy chain gene expression in skeletal muscle development.
Developmental Biology.
312-326.
1999
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Myonuclear domains in muscle adaptation and disease.
Muscle and Nerve.
1350-1360.
1999
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GENETIC-EFFECTS ON VARIOUS MEASURES OF ETHANOL DEPENDENCE IN MICE - A DIALLEL ANALYSIS.
Drug and Alcohol Dependence.
125-132.
1984
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SELECTIVE BREEDING FOR A MULTIVARIATE INDEX OF ETHANOL DEPENDENCE IN MICE - RESULTS FROM THE 1ST 5 GENERATIONS.
Alcoholism: Clinical and Experimental Research.
443-447.
1983
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ETHANOL ELIMINATION RATES IN MICE - EFFECTS OF GENDER, NUTRITION, AND CHRONIC ETHANOL TREATMENT.
Pharmacology, Biochemistry and Behavior.
757-760.
1982
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LACK OF ASSOCIATION BETWEEN PREFERENCE FOR AND DEPENDENCE ON ETHANOL.
Drug and Alcohol Dependence.
119-125.
1982
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BEHAVIORAL AND PHYSIOLOGICAL MEASURES FOR STUDYING ETHANOL DEPENDENCE IN MICE.
Pharmacology, Biochemistry and Behavior.
55-59.
1981
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Guidelines for animal exercise and training protocols for cardiovascular studies.
American Journal of Physiology: Heart and Circulatory Physiology.
H1100-H1138.
2020
Teaching
courses taught
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PSYC 2012 - Biological Psychology
Primary Instructor - Spring 2018 / Summer 2018 / Fall 2018 / Spring 2019 / Summer 2019 / Fall 2019 / Spring 2020 / Summer 2020 / Fall 2020 / Spring 2021 / Summer 2021 / Fall 2021 / Spring 2022 / Summer 2022 / Fall 2022 / Spring 2023 / Summer 2023 / Fall 2023 / Spring 2024 / Summer 2024 / Fall 2024
Surveys biological bases of learning, motivation, emotion, sensory processes and perception, movement,comparative animal behavior, sexual and reproductive activity, instinctual behavior, neurobiology of language and thought, and neurophysiology and neuroanatomy in relation to behavior. -
PSYC 4021 - Psychology and Neuroscience of Exercise
Primary Instructor - Spring 2018 / Spring 2019 / Fall 2019 / Spring 2020 / Fall 2020 / Spring 2021 / Fall 2021 / Spring 2022 / Fall 2022 / Spring 2023 / Summer 2023 / Fall 2023 / Spring 2024 / Summer 2024 / Fall 2024
Explores social, cognitive, psychobiological and behavioral aspects of exercise and other forms of physical activity. Examines how psychological and neuroscience research have been used to study how participation in regular physical activity affects mental health and how psychological and other variables influence participation in, adherence to, enjoyment of, and consequences of exercise and physical activity. -
PSYC 4031 - Sport Psychology
Primary Instructor - Spring 2018 / Spring 2019 / Spring 2020 / Spring 2021 / Spring 2022 / Spring 2023 / Spring 2024
Explores the role psychological factors play in the participation in, performance in, and enjoyment of sport. Topics include the role of motivation, attention, arousal, psychological skills training, leadership, and teamwork in sport performance; the psychological variables influencing exercise addiction, overtraining, burnout, body image, and susceptibility to, and recovery from, athletic injuries; and competition, cooperation aggression, and moral behavior in sport.
Background
education and training
- Ph.D., University of California-Los Angeles 1996
- B.S., University of California-Los Angeles 1991