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Klymkowsky, Mike

Professor

Positions

Research Areas research areas

Research

research overview

  • Moving on from studies using Xenopus we are now using human cells and induced pluripotent stem cells. We have constructed CRISPR-CAS9 plasmids for generating vimentin- (and other) null human cells. As an assay system we are working on the generation of adhesive island cultures and examining the behavior of iPSCs in a 'negligible-cost' media, with the goal of examining the possible effects of molecular chaperones on vimentin-null phenotypes. Our educational studies focus on how the design of instructional materials influence student engagement, thinking, and learning outcomes. With Melanie Cooper at Michigan State University, we have produced free (open educational resources) and redesigned textbooks for courses in general and organic chemistry (CLUE/OCLUE) and molecular biology (biofundamentals), together with a web-based graphical assessment system (beSocratic) and a Socratic-chat system (with Ann Riedl at Front Range Community College). The introduction of Chat-GPT (and related tools) makes rapid socratic responses to students' answers and queries possible, and we are exploring the possibility of using such tools in both beSocratic and SocraticChat systems, as well as the feasibility of transforming these tools into independent not-for-profit entities. We are encouraged by the recent demonstrated impacts on student learning and success of concept-based materials (e.g. CLUE). In particular, work by Ralph et al., (2022. Advancing Equity in STEM: JACS Au, 2, 1869-1880) indicates that a greater conceptual focus can positively impact the success of under-privileged students and improve learning outcomes for all students. I am also exploring the possibility of writing a new textbook on social cell biology and developmental mechanisms. We are building on both projects to develop a module for the SkillCenter Course (MCDB 1234) aimed at providing students with real world technical training.

keywords

  • cell and molecular biology, developmental mechanisms, mutational effects and cellular stress, course and curricular design, the evaluation and improvement of science (biology) education, interactive instructional materials

Publications

selected publications

Teaching

courses taught

  • EBIO 4811 - Teaching and Learning Biology
    Primary Instructor - Fall 2020
    Provides an introduction to recent research into student learning on the conceptual foundations of modern biology, together with pedagogical methods associated with effective instruction and its evaluation. Students will be involved in active research into conceptual and practical issues involved in biology education, methods to discover student preconceptions, and the design, testing and evaluation of various instructional interventions. Recommended prerequisites: MCDB 1150 or EBIO 1210 and MCDB 2150 and MCDB 3145. Same as EDUC 6811 and MCDB 4811 and MCDB 5811 and EDUC 4811.
  • EDUC 4811 - Teaching and Learning Biology
    Primary Instructor - Fall 2020
    Provides an introduction to recent research into student learning on the conceptual foundations of modern biology, together with pedagogical methods associated with effective instruction and its evaluation. Students will be involved in active research into conceptual and practical issues involved in biology education, methods to discover student preconceptions, and the design, testing and evaluation of various instructional interventions. Same as EDUC 6811 and MCDB 4811 and MCDB 5811 and EBIO 4811. Recommended prerequisites: MCDB 1150 or EBIO 1210 and MCDB 2150 and MCDB 3145.
  • EDUC 6811 - Teaching and Learning Biology
    Primary Instructor - Fall 2020
    Provides an introduction to recent research into student learning on the conceptual foundations of modern biology, together with pedagogical methods associated with effective instruction and its evaluation. Students will be involved in active research into conceptual and practical issues involved in biology education, methods to discover student preconceptions, and the design, testing and evaluation of various instructional interventions. Same as EDUC 4811 and MCDB 4811 and MCDB 5811.
  • FYSM 1000 - First Year Seminar
    Primary Instructor - Fall 2018
    Provide first year students with an immersive experience in an interdisciplinary topic that addresses current issues including social, technical and global topics. Taught by faculty from across campus, the course provides students with an opportunity to interact in small classes, have project based learning experiences and gain valuable communication skills. Seminar style classes focused on discussion and projects.
  • MCDB 2222 - Core Concepts in Biology II: Genes, Genetics and Phenotypes
    Primary Instructor - Spring 2018
    Web-based, in-class discussion course focused on the origins of genetic variation and inheritance, genome dynamics and gene expression and their relationship to phenotype(s). Interpreting, explaining and answering questions scientifically as well as quantitative reasoning are stress. Course fulfills the departmental requirement for MCDB 2150. Degree credit not granted for this course and MCDB 2150.
  • MCDB 4100 - Special Topics
    Primary Instructor - Spring 2018
    May be repeated up to 6 total credit hours. Recommended prerequisites: MCDB 3135 and MCDB 3145 (minimum grade C-).
  • MCDB 4101 - Editing Genomes with CRISPR-Cas9 Discovering Gene Function
    Primary Instructor - Fall 2019
    Discover novel gene function in vertebrate embryonic development using the latest gene-editing technology, CRISPR-Cas9. Pick your gene of interest and design experiments to mutate the gene, confirm the mutation and characterize the phenotype. Search scientific databases to learn more about the gene and formulate a hypothesis about the gene function. Discuss and present your findings to your peer and faculty. Recommended prerequisites: MCDB 3135 and MCDB 3145.
  • MCDB 4650 - Developmental Biology
    Primary Instructor - Spring 2019 / Spring 2020 / Spring 2021 / Fall 2021 / Fall 2022
    Explores the development of invertebrate and vertebrate organisms, emphasizing cellular, molecular and genetic mechanisms. Focuses on conceptual understanding and experimental approaches to topics such as embryology, developmental control of gene expression in eukaryotic cells, mechanisms of differentiation and morphogenesis and developmental genetics. Same as MCDB 5651.
  • MCDB 4811 - Teaching and Learning Biology
    Primary Instructor - Fall 2020
    Provides an introduction to recent research into student learning on the conceptual foundations of modern biology, together with pedagogical methods associated with effective instruction and its evaluation. Students will be involved in active research into conceptual and practical issues involved in biology education, methods to discover student preconceptions, and the design, testing and evaluation of various instructional interventions. Same as EDUC 6811 and EDUC 4811 and MCDB 5811 and EBIO 4811. Recommended prerequisites: MCDB 1150 or EBIO 1210 and MCDB 2150 and MCDB 3145.
  • MCDB 5651 - Developmental Biology
    Primary Instructor - Fall 2021 / Fall 2022
    Explores the development of invertebrate and vertebrate organisms, emphasizing cellular, molecular and genetic mechanisms. Focuses on conceptual understanding and experimental approaches to topics such as embryology, developmental control of gene expression in eukaryotic cells, mechanisms of differentiation and morphogenesis and developmental genetics. Same as MCDB 4650.
  • MCDB 5811 - Teaching and Learning Biology
    Primary Instructor - Fall 2020
    Provides an introduction to recent research into student learning on the conceptual foundations of modern biology, together with pedagogical methods associated with effective instruction and its valuation. Students will be involved in active research into conceptual and practical issues involved in biology education, methods to discover student preconceptions, and the design, testing and evaluation of various instructional interventions. Same as MCDB 4811 and EDUC 4811 and EDUC 6811.

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