Dr. Singh's laboratory studies post-transcriptional gene regulation. The focus is on how RNA-binding proteins control molecular processes during male and female germline stem cell differentiation and to understand the basis for the Down syndrome. His lab uses Drosophila, fission yeast, and cultured cells as model organisms or systems and involves a combination of computational, biochemical, molecular and genetic approaches to address the basis of specificity, which is the key aspect of gene regulation.
MCDB 3135 - Molecular Biology
Primary Instructor
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Spring 2018 / Summer 2018 / Summer 2020 / Spring 2021 / Summer 2021 / Summer 2022 / Summer 2023 / Summer 2024
Examines the central dogma of biology by discussing the most important molecules in cells (DNA, RNA and protein) and how their synthesis (DNA replication, transcription, RNA processing and translation) is regulated. Incorporated into the discussion is how recombinant DNA techniques are used to discover and dissect cellular processes, how to design and interpret experiments, and understanding the limits of experiments to draw conclusions.
MCDB 3150 - Biology of the Cancer Cell
Primary Instructor
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Spring 2020 / Fall 2021 / Fall 2022 / Fall 2023 / Fall 2024
Highlights dimensions of the cancer problem; cancer as a genetic/cellular disease; chemicals, viruses, and radiation as causes of cancer; cancer and diet; cancer epidemiology; cancer risk factors; proto-oncogenes, oncogenes, and cancer suppressor genes; and prevention of cancer. Recommended prerequisite: MCDB 2150 or EBIO 2070 (minimum grade C-).
MCDB 3300 - Personalized Medicine - Recent Advances in Diagnostics and Therapeutics
Primary Instructor
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Spring 2020 / Spring 2021 / Spring 2022 / Spring 2023 / Spring 2024
Time for personalized medicine is now. Attempts to learn from and put the patient/person back into the equation because personalized medicine, at its worst, does nothing personal at all. Discusses historical perspective, recent advances in molecular biology and medicine (including OMICS) in regards to diagnostics and therapeutics for selected human diseases, and what the future holds for personalized medicine. Guest lectures (medical experts, patients, family members) will further enrich the course. Recommended prerequisites: MCDB 2150 or EBIO 2070.
MCDB 3333 - Biomedical Innovations and Discoveries
Primary Instructor
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Fall 2018 / Fall 2019 / Fall 2020 / Fall 2021 / Fall 2022 / Fall 2023 / Fall 2024
Discusses how biological inventions and discoveries fuel biomedical innovations, how important techniques in molecular biology have advanced our understanding of cellular processes and contributed to biotechnology revolution and biomedical sciences to benefit our society. Guest lectures from experts in industry and site visits will enhance the course by providing a non-academic perspective, networking opportunities, and unexpected avenues for career paths for our graduates. Department enforced prerequisite: MCDB 2150 or EBIO 2070 or instructor consent.
MCDB 4471 - Mechanisms of Gene Regulation in Eukaryotes
Primary Instructor
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Spring 2018 / Fall 2019 / Fall 2020 / Spring 2022 / Spring 2023 / Spring 2024
Focuses on manifestations of regulated gene expression. Studies gene regulation at multiple steps, including transcription, RNA processing and translation. Is based on critical analysis of primary research papers. Written assignments and oral presentations are required. Fulfills MCDB scientific reasoning requirement. Recommended prerequisite: MCDB 3135 (minimum grade C-) or instructor consent required. Same as MCDB 5471.
MCDB 4980 - Honors Research
Primary Instructor
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Fall 2021
Provides faculty-supervised research for students who have been approved by the departmental honors committee. Normally taken during the semester before completion of the honors thesis. Recommended prerequisite: MCDB 4840 or comparable research experience, and minimum GPA of 3.20.
MCDB 5471 - Mechanisms of Gene Regulation in Eukaryotes
Primary Instructor
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Spring 2018 / Fall 2019 / Fall 2020 / Spring 2022 / Spring 2023 / Spring 2024
Focuses on manifestations of regulated gene expression. Studies gene regulation at multiple steps, including transcription, RNA processing and translation. Is based on critical analysis of primary research papers. Written assignments and oral presentations are required. Same as MCDB 4471.
