Subcortical hyperintensities on MRI and activities of daily living in geriatric depression. Journal Article uri icon



  • Data from 30 elderly inpatients with major depression were analyzed to explore the relationship between subcortical hyperintensities (SH) on MRI and activities of daily living (ADLs). A comparison of subjects based on a median split of the severity of SH revealed that subjects with greater SH performed worse on both instrumental and physical ADLs. A hierarchical multiple regression revealed that age, depression severity, neuropsychological test performance, and SH variables accounted for a total of 53% of the variance in ADL functioning. Severity of SH accounted for an additional 18% of the variance over and above the other three variables. Results suggest that severity of subcortical disease measured by MRI improves prediction of functional impairment in elderly individuals.

publication date

  • January 1, 1996

has restriction

  • closed

Date in CU Experts

  • October 30, 2013 3:09 AM

Full Author List

  • Cahn DA; Malloy PF; Salloway S; Rogg J; Gillard E; Kohn R; Tung G; Richardson ED; Westlake R

author count

  • 9

Other Profiles

International Standard Serial Number (ISSN)

  • 0895-0172

Additional Document Info

start page

  • 404

end page

  • 411


  • 8


  • 4