4-Aminopyridine induced hyperpolarizing oscillations in pediatric human epileptic tissue are network-driven potassium currents that are abolished by activation of KCNQ2-5 (Kv7.2-Kv7.5) channels
Journal Article
Overview
publication date
- January 1, 2026
has subject area
- Amines - 4-Aminopyridine
- Cardiovascular Agents - Potassium Channel Blockers
- Carrier Proteins - KCNQ2 Potassium Channel
- Cell Physiological Phenomena - Action Potentials
- Cells - Pyramidal Cells
- Child
- Electrophysiological Phenomena - Action Potentials
- Epilepsy
- Female
- Humans
- Male
- Membrane Proteins - KCNQ2 Potassium Channel
- Membrane Proteins - KCNQ2 Potassium Channel
- Membrane Transport Modulators - Potassium Channel Blockers
- Neocortex
- Nerve Net
- Nervous System - Pyramidal Cells
- Nervous System Physiological Phenomena - Action Potentials
- Pyridines - 4-Aminopyridine
Date in CU Experts
- January 2, 2026 7:20 AM
Full Author List
- Kushner JK; Hoffman PB; Brzezinski CR; O'Neill BR; Hankinson TC; Wilkinson CC; Handler MH; Hoeffer CA; Alexander AL
author count
- 9
citation count
- 1
published in
- Neurobiology of Disease Journal
Other Profiles
International Standard Serial Number (ISSN)
- 0969-9961
Electronic International Standard Serial Number (EISSN)
- 1095-953X
Digital Object Identifier (DOI)
Additional Document Info
volume
- 218
number
- ARTN 107252