Determining the stability of genome-wide factors in BMI between ages 40 to 69 years. Journal Article uri icon



  • Genome-wide association studies (GWAS) have successfully identified common variants associated with BMI. However, the stability of aggregate genetic variation influencing BMI from midlife and beyond is unknown. By analysing 165,717 men and 193,073 women from the UKBiobank, we performed BMI GWAS on six independent five-year age intervals between 40 and 72 years. We then applied genomic structural equation modeling to test competing hypotheses regarding the stability of genetic effects for BMI. LDSR genetic correlations between BMI assessed between ages 40 to 73 were all very high and ranged 0.89 to 1.00. Genomic structural equation modeling revealed that molecular genetic variance in BMI at each age interval could not be explained by the accumulation of any age-specific genetic influences or autoregressive processes. Instead, a common set of stable genetic influences appears to underpin genome-wide variation in BMI from middle to early old age in men and women alike.

publication date

  • August 1, 2022

has subject area

has restriction

  • gold

Date in CU Experts

  • January 30, 2024 9:49 AM

Full Author List

  • Gillespie NA; Gentry AE; Kirkpatrick RM; Reynolds CA; Mathur R; Kendler KS; Maes HH; Webb BT; Peterson RE

author count

  • 9

Other Profiles

Electronic International Standard Serial Number (EISSN)

  • 1553-7404

Additional Document Info

start page

  • e1010303


  • 18


  • 8