Genetic and Environmental Influences on Semantic Verbal Fluency Across Midlife and Later Life. Journal Article uri icon



  • Despite the relevance of semantic fluency measures to risk for dementia and psychiatric disorders, little is known about their genetic and environmental architecture in mid-to-late life. Participants represent 21,684 middle-aged and older adult twins (M = 60.84 years, SD = 11.21; Range 40-89) from six studies from three countries participating in the Interplay of Genes and Environment across Multiple Studies (IGEMS) consortium. All completed the same measure of semantic fluency (naming animals in 60 seconds). Results revealed small-to-moderate phenotypic associations with age and education, with education more strongly and positively associated with fluency performance in females than males. Heritability and environmental influences did not vary by age. Environmental variance was smaller with higher levels of education, but this effect was observed only in males. This is the largest study to examine the genetic and environmental architecture of semantic fluency, and the first to demonstrate that environmental influences vary based on levels of education.

publication date

  • March 1, 2021

has restriction

  • green

Date in CU Experts

  • April 13, 2023 8:34 AM

Full Author List

  • Gustavson DE; Panizzon MS; Kremen WS; Reynolds CA; Pahlen S; Nygaard M; Wod M; Catts VS; Lee T; Gatz M

author count

  • 12

Other Profiles

Electronic International Standard Serial Number (EISSN)

  • 1573-3297

Additional Document Info

start page

  • 99

end page

  • 109


  • 51


  • 2