The MUC5B-associated variant rs35705950 resides within an enhancer subject to lineage- and disease-dependent epigenetic remodeling
Journal Article
Overview
publication date
- January 25, 2021
has subject area
- Binding Sites
- Biochemical Phenomena - Enhancer Elements, Genetic
- Carrier Proteins - STAT3 Transcription Factor
- Cell Line
- Cell Line - A549 Cells
- DNA-Binding Proteins - Proto-Oncogene Proteins c-ets
- Disease Attributes - Genetic Predisposition to Disease
- Epigenesis, Genetic
- Epithelial Cells - A549 Cells
- Gain of Function Mutation
- Gene Expression Regulation
- Genetic Structures - Chromatin
- Genetic Structures - Enhancer Elements, Genetic
- Genotype - Genetic Predisposition to Disease
- Humans
- Idiopathic Pulmonary Fibrosis
- Intranuclear Space - Chromatin
- Lung
- Models, Genetic
- Mucins - Mucin-5B
- Nucleoproteins - Chromatin
- Peptides - Mucin-5B
- Peptides - STAT3 Transcription Factor
- Polymorphism, Single Nucleotide
- Proteins - Mucin-5B
- Proteins - STAT3 Transcription Factor
- Proto-Oncogene Proteins - Proto-Oncogene Proteins c-ets
- RNA Polymerase II
- Regulatory Elements, Transcriptional - Enhancer Elements, Genetic
- Transcription Factors - Proto-Oncogene Proteins c-ets
- Transcription Factors - STAT3 Transcription Factor
- Tumor Cells, Cultured - A549 Cells
has restriction
- gold
Date in CU Experts
- February 1, 2022 7:01 AM
Full Author List
- Gally F; Sasse SK; Kurche JS; Gruca MA; Cardwell JH; Okamoto T; Chu HW; Hou X; Poirion OB; Buchanan J
author count
- 17
citation count
- 15
published in
- JCI Insight Journal
Other Profiles
Electronic International Standard Serial Number (EISSN)
- 2379-3708
Digital Object Identifier (DOI)
Additional Document Info
volume
- 6
issue
- 2
number
- ARTN e144294