Regulatory approved monoclonal antibodies contain framework mutations predicted from human antibody repertoires
Journal Article
Overview
publication date
- September 27, 2021
has subject area
- Biochemical Phenomena - Immunoglobulin Variable Region
- Biochemical Phenomena - Molecular Dynamics Simulation
- Biological Science Disciplines - Drug Development
- Blood Proteins - Antibodies, Monoclonal
- Blood Proteins - Immunoglobulin Heavy Chains
- Blood Proteins - Immunoglobulin Variable Region
- Blood Proteins - Immunoglobulin Variable Region
- Chemistry - Drug Development
- Computer Simulation - Molecular Dynamics Simulation
- DNA Mutational Analysis
- Drug Stability
- Epitopes, T-Lymphocyte
- Globulins - Antibodies, Monoclonal
- Globulins - Immunoglobulin Heavy Chains
- Globulins - Immunoglobulin Variable Region
- Globulins - Immunoglobulin Variable Region
- Humans
- Immunoproteins - Antibodies, Monoclonal
- Immunoproteins - Immunoglobulin Heavy Chains
- Immunoproteins - Immunoglobulin Variable Region
- Immunoproteins - Immunoglobulin Variable Region
- Information Science - Databases, Genetic
- Information Systems - Databases, Genetic
- Investigative Techniques - Drug Approval
- Investigative Techniques - Drug Approval
- Investigative Techniques - Drug Development
- Models, Genetic
- Models, Molecular - Molecular Dynamics Simulation
- Mutation
- Organizations - United States Food and Drug Administration
- Peptide Fragments - Immunoglobulin Variable Region
- Protein Stability
- Social Sciences - Drug Approval
- Social Sciences - United States Food and Drug Administration
- United States
has restriction
- green
Date in CU Experts
- June 30, 2021 10:24 AM
Full Author List
- Petersen BM; Ulmer SA; Rhodes ER; Gutierrez-Gonzalez MF; Dekosky BJ; Sprenger KG; Whitehead TA
author count
- 7
citation count
- 4
published in
- Frontiers in Immunology Journal
Other Profiles
International Standard Serial Number (ISSN)
- 1664-3224
Digital Object Identifier (DOI)
Additional Document Info
volume
- 12