Enantioselective Tandem Cyclization of Alkyne‐Tethered Indoles Using Cooperative Silver(I)/Chiral Phosphoric Acid Catalysis Journal Article uri icon



  • AbstractReported is the enantioselective synthesis of tetracyclic indolines using silver(I)/chiral phosphoric acid catalysis. A variety of alkyne‐tethered indoles are suitable for this process. Mechanistic studies suggest that the in situ generated silver(I) chiral phosphate activates both the alkyne and the indole nucleophile in the initial cyclization step through an intermolecular hydrogen bond and the phosphate anion promotes proton transfer. In addition, further modifications of the cyclization products enabled stereochemistry–function studies of a series of bioactive indolines.

publication date

  • September 25, 2017

has restriction

  • closed

Date in CU Experts

  • November 4, 2020 12:03 PM

Full Author List

  • Zhu Y; He W; Wang W; Pitsch CE; Wang X; Wang X

author count

  • 6

Other Profiles

International Standard Serial Number (ISSN)

  • 0044-8249

Electronic International Standard Serial Number (EISSN)

  • 1521-3757

Additional Document Info

start page

  • 12374

end page

  • 12377


  • 129


  • 40