Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1-Parkin pathway and modulate cellular drug response
Journal Article
Overview
publication date
- September 8, 2017
has subject area
- ATP Synthetase Complexes - Mitochondrial Proton-Translocating ATPases
- Acids, Heterocyclic - Niacinamide
- Acids, Heterocyclic - Sorafenib
- Adenosine Triphosphatases - Mitochondrial Proton-Translocating ATPases
- Benzene Derivatives - Phenylurea Compounds
- Benzene Derivatives - Sorafenib
- Biochemical Phenomena - Electron Transport
- Carrier Proteins - Electron Transport Complex II
- Carrier Proteins - Electron Transport Complex III
- Carrier Proteins - Electron Transport Complex III
- Carrier Proteins - Mitochondrial Proton-Translocating ATPases
- Cell Line, Transformed - HEK293 Cells
- Cells, Cultured
- Energy Metabolism - Electron Transport
- Enzymes - Electron Transport Complex II
- Enzymes - Electron Transport Complex II
- Enzymes - Electron Transport Complex III
- Epithelial Cells - HEK293 Cells
- Flavoproteins - Electron Transport Complex II
- Humans
- Membrane Proteins - Electron Transport Complex II
- Membrane Proteins - Electron Transport Complex II
- Membrane Proteins - Electron Transport Complex III
- Membrane Proteins - Electron Transport Complex III
- Membrane Proteins - Mitochondrial Proton-Translocating ATPases
- Membrane Proteins - Mitochondrial Proton-Translocating ATPases
- Metabolic Networks and Pathways - Electron Transport
- Metalloproteins - Electron Transport Complex II
- Metalloproteins - Electron Transport Complex III
- Mitochondrial Proteins - Mitochondrial Proton-Translocating ATPases
- Multiprotein Complexes - Electron Transport Complex II
- Multiprotein Complexes - Electron Transport Complex III
- Organelles - Mitochondria
- Oxidoreductases - Electron Transport Complex II
- Oxidoreductases - Electron Transport Complex III
- Oxidoreductases Acting on CH-CH Group Donors - Electron Transport Complex II
- Protein Kinases
- Pyridines - Niacinamide
- Pyridines - Sorafenib
- Subcellular Fractions - Mitochondria
- Ubiquitin-Protein Ligases
- Urea - Phenylurea Compounds
- Urea - Sorafenib
has restriction
- hybrid
Date in CU Experts
- July 5, 2017 8:16 AM
Full Author List
- Zhang C; Liu Z; Bunker E; Ramirez A; Lee S; Peng Y; Tan A-C; Eckhardt SG; Chapnick DA; Liu X
author count
- 10
citation count
- 61
published in
- Journal of Biological Chemistry Journal
Other Profiles
Electronic International Standard Serial Number (EISSN)
- 1083-351X
Digital Object Identifier (DOI)
Additional Document Info
start page
- 15105
end page
- 15120
volume
- 292
issue
- 36