Oestrogen enhances cardiotoxicity induced by Sunitinib by regulation of drug transport and metabolism
Journal Article
Overview
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Alcohols - Phenylephrine
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Amines - Phenylephrine
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Animals
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Biochemical Phenomena - Phosphorylation
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Biological Transport
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Carrier Proteins - ATP Binding Cassette Transporter, Subfamily B, Member 1
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Carrier Proteins - ATP Binding Cassette Transporter, Subfamily B, Member 1
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Drug-Related Side Effects and Adverse Reactions - Cardiotoxicity
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Enzymes and Coenzymes - Cytochrome P-450 CYP1A1
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Enzymes and Coenzymes - Cytochrome P-450 CYP1A1
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Estrogens
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Female
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Heart - Myocytes, Cardiac
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Heart Diseases - Cardiotoxicity
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Hemeproteins - Cytochrome P-450 CYP1A1
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Hemeproteins - Cytochrome P-450 CYP1A1
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Indoles
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Indoles - Sunitinib
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Male
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Membrane Proteins - ATP Binding Cassette Transporter, Subfamily B, Member 1
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Membrane Proteins - ATP Binding Cassette Transporter, Subfamily B, Member 1
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Membrane Proteins - ATP Binding Cassette Transporter, Subfamily B, Member 1
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Metabolism - Phosphorylation
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Mice
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Mixed Function Oxygenases - Cytochrome P-450 CYP1A1
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Mixed Function Oxygenases - Cytochrome P-450 CYP1A1
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Muscle Cells - Myocytes, Cardiac
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Muscle, Striated - Myocytes, Cardiac
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Organic Chemistry Phenomena - Phosphorylation
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Pathologic Processes - Cardiotoxicity
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Pharmacological Phenomena - Dose-Response Relationship, Drug
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Proteins - ATP Binding Cassette Transporter, Subfamily B, Member 1
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Pyrroles
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Pyrroles - Sunitinib
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Radiation - Cardiotoxicity
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Rats
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Rats, Sprague-Dawley
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Sex Characteristics
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Toxicological Phenomena - Dose-Response Relationship, Drug
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Type C Phospholipases
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Wounds and Injuries - Cardiotoxicity
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