Methods for estimating heritability and investigating the genetic architecture of complex traits, focusing on the heritability and genetic architecture of human psychiatric disorders and substance use and dependence. This includes identifying genetic variants that contribute to disorder liability, integrating whole genome and transcriptome data, understanding gene-gene and gene-by-environment interactions, and testing how these factors influence risk prediction. Selection and adaptation. Identifying quantitative and molecular signatures of selection, both recent positive selection and purifying selection. This uses statistical genetic approaches with genome-wide marker data to infer patterns of selection throughout the genome.
