The African Development Bank has called for $40 Billion USD per year over the coming decades to be provided to African countries to address development issues directly related to climate change. The current study addresses a key component of these issues, the effect of climate change on the road infrastructure of Malawi, Mozambique, and Zambia. The study incorporates a stressor-response approach to estimate the effects of projected precipitation, temperature, and flooding changes on the paved and unpaved road infrastructure of these countries. The paper highlights the result of running 425 climate scenarios for each road type and policy option from 2010 to 2050. Based on this broad analysis, it is estimated that the three southern African countries are facing a potential $596 million price tag based on median climate scenarios to maintain and repair roads as a result of damages directly related to temperature and precipitation changes from potential climate change through 2050. The challenge for policy makers is to determine the potential risk that a country is facing based on the uncertainties associated with the multiple aspects of climate change modeling.