Ribonuclease P Catalysis Differs from Ribosomal RNA Self-Splicing Journal Article uri icon



  • ; Two RNA-catalyzed reactions have been described, the; Tetrahymena; self-splicing ribosomal RNA and ribonuclease P. The; Tetrahymena; self-splicing reaction proceeds through a transesterification cascade that is dependent upon nucleophilic attacks by ribose 3′-OH groups. Periodate oxidation of the catalytic (or substrate) RNA, which destroys the nucleophilicity of RNA 3′ termini, did not inhibit ribonuclease P activity. Thus, catalysis by ribonuclease P differs from the self-splicing reaction.;

publication date

  • July 5, 1985

has restriction

  • closed

Date in CU Experts

  • May 8, 2014 10:36 AM

Full Author List

  • Marsh TL; Pace NR

author count

  • 2

Other Profiles

International Standard Serial Number (ISSN)

  • 0036-8075

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

Additional Document Info

start page

  • 79

end page

  • 81


  • 229


  • 4708