Caspase 7 Is a Positional Candidate Gene for IDDM 17 in a Bedouin Arab Family Journal Article uri icon

Overview

abstract

  • Abstract: The IDDM 17 locus was mapped to an 8‐cM interval at chromosome 10q25.1 based on linkage in a large Bedouin Arab family with 19 affected relatives. Caspase 7 (CASP7), an apoptosis‐related cysteine protease, is one of the few known genes in this region. CASP7 is involved in the activation cascade of caspases responsible for apoptosis execution. Only 1 of the 18 SNPs in CASP7 (SNP144692) differed significantly in frequency in the haplotypes found in affected individuals compared to control Bedouin haplotypes. This same SNP showed evidence of association with diabetes in a subset of patients (DR3/DR4*0302) from HBDI families.

publication date

  • November 1, 2003

has restriction

  • closed

Date in CU Experts

  • February 19, 2014 9:00 AM

Full Author List

  • BABU SR; BAO FEI; ROBERTS CM; MARTIN AK; GOWAN K; EISENBARTH GS; FAIN PR

author count

  • 7

Other Profiles

International Standard Serial Number (ISSN)

  • 0077-8923

Electronic International Standard Serial Number (EISSN)

  • 1749-6632

Additional Document Info

start page

  • 340

end page

  • 343

volume

  • 1005

issue

  • 1