Admixture analysis of a rural population of the state of Guerrero, Mexico Journal Article uri icon

Overview

abstract

  • AbstractWe studied 156 individuals of Native American descent from the city of Tlapa in the state of Guerrero in western Mexico. Most individuals' ethnicity was either Nahua, Mixtec, or Tlapanec, but self‐identified Mestizos and individuals of mixed ethnicities were also included in the sample. We typed 24 autosomal, one Y‐chromosome, and four mitochondrial ancestry‐informative markers (AIMs) to estimate group and individual admixture proportions, and determine whether the admixture process involved directional gene flow between parental groups. When genetically defined (GD) Mestizos were excluded from the analysis, Native American ancestry represented ∼98% of the population's gene pool, while European and West African ancestry represented ∼1% each. Maternally inherited markers also showed an exceptionally high Native American contribution (98.5%), as did the paternally inherited marker, DYS199 (90.7%). We did not detect genetic structure in this population using these AIMs, which appears consistent with the homogeneity of the sample in terms of admixture proportions. The addition of GD Mestizos to the sample did not produce a considerable change in admixture estimates, but it had a major effect on population structure. These results show that the population of Tlapa in Guerrero, Mexico, has experienced little admixture with Europeans and/or West Africans. They also show that the impact of a small number of admixed individuals on an otherwise homogeneous population might have profound implications on subsequent ancestry/phenotype analysis and mapping strategies. We suggest that heterogeneity is a major characteristic of Mexican populations and, as a consequence, should not be disregarded when designing epidemiological studies of Mexican and Mexican American populations. Am J Phys Anthropol., 2005 © 2005 Wiley‐Liss, Inc.

publication date

  • December 1, 2005

has restriction

  • closed

Date in CU Experts

  • November 4, 2013 12:51 PM

Full Author List

  • Bonilla C; Gutiérrez G; Parra EJ; Kline C; Shriver MD

author count

  • 5

Other Profiles

International Standard Serial Number (ISSN)

  • 0002-9483

Electronic International Standard Serial Number (EISSN)

  • 1096-8644

Additional Document Info

start page

  • 861

end page

  • 869

volume

  • 128

issue

  • 4