Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course Journal Article uri icon



  • AbstractWe test whether genetic influences that explain individual differences in aggression in early life also explain individual differences across the life-course. In two cohorts from The Netherlands (N = 13,471) and Australia (N = 5628), polygenic scores (PGSs) were computed based on a genome-wide meta-analysis of childhood/adolescence aggression. In a novel analytic approach, we ran a mixed effects model for each age (Netherlands: 12–70 years, Australia: 16–73 years), with observations at the focus age weighted as 1, and decaying weights for ages further away. We call this approach a ‘rolling weights’ model. In The Netherlands, the estimated effect of the PGS was relatively similar from age 12 to age 41, and decreased from age 41–70. In Australia, there was a peak in the effect of the PGS around age 40 years. These results are a first indication from a molecular genetics perspective that genetic influences on aggressive behavior that are expressed in childhood continue to play a role later in life.

publication date

  • September 1, 2021

has restriction

  • hybrid

Date in CU Experts

  • January 26, 2023 2:10 AM

Full Author List

  • van der Laan CM; Morosoli-García JJ; van de Weijer SGA; Colodro-Conde L; Ip HF; van der Laan CM; Krapohl EML; Brikell I; Sánchez-Mora C; Nolte IM

author count

  • 164

Other Profiles

International Standard Serial Number (ISSN)

  • 0001-8244

Electronic International Standard Serial Number (EISSN)

  • 1573-3297

Additional Document Info

start page

  • 592

end page

  • 606


  • 51


  • 5