Persistence of Varicella-Zoster Virus-Specific Plasma Cells in Adult Human Bone Marrow following Childhood Vaccination Journal Article uri icon



  • Childhood varicella-zoster virus (VZV) immunization induces immune memory responses that protect against primary VZV infection, chicken pox. In the United States, routine childhood VZV vaccination was introduced only 2 decades ago. Hence, there is limited information on the longevity of B and CD4 T cell memory, which are both important for protection. Here, we showed in 15 healthy young adults that VZV-specific B and CD4 T cell responses are detectable in bone marrow (BM) and blood up to 20 years after vaccination. Specifically, we measured antibody-secreting plasma cells in the BM and VZV-specific CD4 T cells in BM and blood. These findings suggest that childhood VZV vaccination induces long-lived immunity.

publication date

  • June 16, 2020

has restriction

  • green

Date in CU Experts

  • January 11, 2023 2:05 AM

Full Author List

  • Eberhardt CS; Wieland A; Nasti TH; Grifoni A; Wilson E; Schmid DS; Pulendran B; Sette A; Waller EK; Rouphael N

Full Editor List

  • Shisler JL

author count

  • 11

Other Profiles

International Standard Serial Number (ISSN)

  • 0022-538X

Electronic International Standard Serial Number (EISSN)

  • 1098-5514

Additional Document Info


  • 94


  • 13