Small Peptide‐Catalyzed Enantioselective Addition of Ketones to Nitroolefins Journal Article uri icon

Overview

abstract

  • AbstractThe direct small peptide‐catalyzed enantioselective Michael addition of ketones to nitroolefins is presented. Simple di‐ and tripeptides derived from alanine catalyze the asymmetric Michael additions with high stereoselectivity and furnish the corresponding Michael products in high yield with up to 68 : 1 dr and 98% ee. The study demonstrates that small, readily prepared peptides with increased structural complexity as compared to the parent amino acid mediate the asymmetric Michael reaction with superior reactivity and enantioselectivity.

publication date

  • March 1, 2006

has restriction

  • closed

Date in CU Experts

  • November 14, 2020 3:27 AM

Full Author List

  • Xu Y; Zou W; Sundén H; Ibrahem I; Córdova A

author count

  • 5

Other Profiles

International Standard Serial Number (ISSN)

  • 1615-4150

Electronic International Standard Serial Number (EISSN)

  • 1615-4169

Additional Document Info

start page

  • 418

end page

  • 424

volume

  • 348

issue

  • 4-5