Insights into the industrial growth of cyanobacteria from a model of the carbon‐concentrating mechanism Journal Article uri icon



  • With the advent of modern bioengineering tools, photosynthetic organisms are increasingly being engineered to produce chemicals from CO2 sources, thereby creating a potential route of sustainable chemical production. Cyanobacteria have evolved a carbon‐concentrating mechanism (CCM) that enables growth at low‐environmental carbon concentrations. However at high‐carbon concentrations these benefits may not outweigh synthesis costs. Here, mass transport and kinetic modeling analyses were performed on two species of cyanobacteria as well as a hypothetical no‐CCM mutant. Modeling results correlated with published experimental data. Three conclusions were drawn from the analysis. Carboxysome geometry was unimportant due to the fast relative rate of diffusion of carbon species. Interspecies variations were largely due to active ; transporters. The no‐carboxysome cell approaches the wild‐type at 10% CO2. Therefore, in high CO2 environments the carboxysome and active bicarbonate transporters provide no benefit and a metabolic advantage could be achieved by eliminating the energy‐intensive CCM proteins. © 2014 American Institute of Chemical Engineers AIChE J, 60: 1269–1277, 2014

publication date

  • April 1, 2014

has restriction

  • closed

Date in CU Experts

  • April 1, 2018 9:45 AM

Full Author List

  • Clark RL; Cameron JC; Root TW; Pfleger BF

author count

  • 4

Other Profiles

International Standard Serial Number (ISSN)

  • 0001-1541

Electronic International Standard Serial Number (EISSN)

  • 1547-5905

Additional Document Info

start page

  • 1269

end page

  • 1277


  • 60


  • 4