My lab is interested in understanding how organelles adapt their morphology and spatial distribution to changing cellular conditions and how proteins and protein complexes that are associated with membranes regulate the structure and function of the organelles in cells. Currently, our research interests are largely directed towards exploring the molecular mechanism of mitochondrial membrane-associated protein networks and characterize their cellular and physiological roles in regulating mitochondrial structure and function. My lab utilizes a multi-disciplinary approach that integrates structure determination by electron cryo-microscopy (cryo-EM) with biochemistry, biophysics, and cell biology techniques to derive unique insights into the complexity of mitochondrial reticulum. Our long-term goal is to elucidate the molecular mechanism of regulated mitochondrial morphology for developing a molecular understanding of mitochondrial function in human cells.
Membrane Biology, Cell Signaling, Proteins and Enzymology, Molecular Biophysics, Structural Biology, Electron Cryo-Microscopy
BCHM 5770 - Fundamentals of Biochemistry I
Analysis of topics in biochemistry including DNA structure and replication, RNA synthesis and processing, protein synthesis, enzyme function and mechanism, and protein structure and dynamics. Intended as a comprehensive treatment of areas central to modern biochemistry for entering graduate students. Lectures concurrent with BCHM 5771 covering the same topics except for the requirement of a written research proposal. Formerly CHEM 5770.
BCHM 5771 - Advanced General Biochemistry 1
Fall 2021 / Fall 2022
Lect. In-depth analysis of DNA structure and replication, RNA synthesis and processing, protein synthesis, enzyme function and mechanism, protein structure, protein dynamics, and physical chemistry of macromolecules. Intended as a comprehensive treatment of areas central to modern biochemistry for entering graduate students. Formerly CHEM 5771.
BCHM 5776 - Scientific Ethics and Responsible Conduct in Research
Fall 2021 / Fall 2022
Lect. Advanced discussion of topics in scientific ethics, including requirements for responsible conduct of research, case histories of fraud, research misconduct, ethical misconduct and development of professional values and ethical standards. Same as MCDB 5776.