The main objective of this multidisciplinary course is to provide students with a broad survey of biomaterials and their use in medical devices for restoring or replacing the functions of injured, diseased, or aged human tissues and organs. The topics to be covered include: evolution in the medical device industry, a broad introduction to the materials used in medicine and their chemical, physical, and biological properties, discovery of medical problems, potential impacts of treatment innovations, existing devices and design considerations for several major physiological systems (cardiovascular, neuromuscular, skeletal, pulmonary, renal, dermal), materials interaction with the human body, basic mechanisms of wound healing, biocompatibility issues, testing methods and techniques in accordance with standards and relevant regulations, biofunctionalities required for specific applications, as well as state-of-the-art approaches for the development of new regenerative materials targeting cellular mechanisms. Recommended prerequisite: knowledge comparable to that gained through MCEN 2024. Same as MCEN 4292.